YL278_YEAST - dbPTM
YL278_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YL278_YEAST
UniProt AC Q05854
Protein Name Uncharacterized transcriptional regulatory protein YLR278C
Gene Name YLR278C
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1341
Subcellular Localization Nucleus .
Protein Description
Protein Sequence MGRPRKNVSQEKIQQLKRELELAGNRTDVLLQDKKGRSRSCLLCRRRKQRCDHKLPSCTACLKAGIKCVQPSKYSSSTSNSNTNNNTPTAGTVPPTPHPVIKRELQDSSIGAGAGAATSLNDMTIIKPISTSNSNVDAGDANEFRKTIKSVTTNSNPNLMRQDKDQYTIFLEKKLKSLETLLDLSPGCNQYNYELSQYKKVSHLFSNNTSDYSRPNSSNMVILPLPSPSNKPLENTNNNGSNVNAATNDTSASTNNINNNNAICQSASLLNDPLETLDFTKCIFAKYNLKKEFLMYDPIFELNEKLSRSFLDTFFTRLQFKYPILDEQEIYTFYDHYLHNKILIPPSSPATSSAAPPSNSHSYSEIEFHFLSGRMWLVFSISAYLLMTTGKYKGFPPHRYFSTAIRHITKCGLHLNYVQQIELLTLLVLYIIRTDRDSLILYDIIKDVMGISKKKLHLNQWYPNDPFANKKLRLFWCVYLLERMICVAVGKPYTIKESEINLPLFNNDSFYTKGVHAAAPSTNDHGVQFINQSLKLRRIESQFVETLQLLKNDSRSVKQSIDQLPLVRKFFEDLEVWRKSYSTLDVKNFENETLKLYYYRSVRLLIQPYLEFFAPEDRLFRECQAAAGQICQLYKIFHQKTLNGHSTPAVHTVFVAGVTLIYCMWLARNFDDQRRKKLGDASKHTRPLISASLFSTMDDLRACSVCLYVMTERSNFARTFRDTFDQLMNATVGNLIERCGPDSSELIFMASSVAKRTEPKNINDEANKAISSGDTLHDSNSANAANLSNSNDKNISHNGGMPPAVARIFGKGQAEEHAGFVENSQVDLAEQEKFKKKQGVLEKTSVPKSLAHLLTKMDDRSRISNSSMSYTTSSSSSSSSSSSSSTLSFPSSQEKNLKINVNNDNNGMTISSVNREHNNNHNNNNDNNNNNNNNNNNSNNNNNVNNNDNESNSRSTTNNSCNNGNNSQYVRNNNVTMENDVERPIQDQYIVKKPTNQTEFDWQVFQQQAFLQQQLAQHNLQAYLSSLNTDTMTNRSPSKSSSISTASSHSDPIPIAMTQSPTPYPQTSNMLPQQHVSRPLPQQQREQPQQHITSPQRFSESNFTNQLNNGMINSNPLQSAIFSNHTSENKQLRDVEESNFSTSPLRADYGNNIISSIPASFTSNSIPVSVKQARNGSSSGDILFSNGAHDMINNISTWTNNSVLDALNSKSILQTIFPQSQEPSSLSMDKQQQQHQQQNMCSENNVTANNFQQTQNDPSYNRNLFMMSNQEGVQYNLDETEKNGPKTQVEANTSANLHFDNVIPTVTNADIRKKRSNWDNMMTSGPVEDFWTINDDYGFLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationDKKGRSRSCLLCRRR
CCCCCCCHHHHHHHH		15.4623749301
72PhosphorylationGIKCVQPSKYSSSTS
CCEEECCCCCCCCCC		27.4319779198
76PhosphorylationVQPSKYSSSTSNSNT
ECCCCCCCCCCCCCC		34.2519779198
79PhosphorylationSKYSSSTSNSNTNNN
CCCCCCCCCCCCCCC		39.9619779198
81PhosphorylationYSSSTSNSNTNNNTP
CCCCCCCCCCCCCCC		44.8119779198
87PhosphorylationNSNTNNNTPTAGTVP
CCCCCCCCCCCCCCC		24.9219779198
89PhosphorylationNTNNNTPTAGTVPPT
CCCCCCCCCCCCCCC		35.3628889911
92PhosphorylationNNTPTAGTVPPTPHP
CCCCCCCCCCCCCCC		27.6328889911
108PhosphorylationIKRELQDSSIGAGAG
CCHHHHCCCCCCCCC		15.7619779198
124PhosphorylationATSLNDMTIIKPIST
CCCCCCCEEEEECCC		23.5519779198
155PhosphorylationIKSVTTNSNPNLMRQ
HHHHHCCCCCCCCCC		52.1230377154
180PhosphorylationKKLKSLETLLDLSPG
HHHHHHHHHHHCCCC		37.6021551504
185PhosphorylationLETLLDLSPGCNQYN
HHHHHHCCCCHHHHH		20.9321440633
193PhosphorylationPGCNQYNYELSQYKK
CCHHHHHHHHHHHHH		17.2021551504
768AcetylationNINDEANKAISSGDT
CCCHHHHHHHHCCCC		54.8922865919
771PhosphorylationDEANKAISSGDTLHD
HHHHHHHHCCCCCCC		32.8828889911
775PhosphorylationKAISSGDTLHDSNSA
HHHHCCCCCCCCCCC		29.5317330950
788PhosphorylationSANAANLSNSNDKNI
CCCCCCCCCCCCCCC		37.7124961812
790PhosphorylationNAANLSNSNDKNISH
CCCCCCCCCCCCCCC		42.9228889911
796PhosphorylationNSNDKNISHNGGMPP
CCCCCCCCCCCCCCH		21.9417330950
856AcetylationSLAHLLTKMDDRSRI
HHHHHHHHCCCCCCC		40.0624489116
960PhosphorylationSRSTTNNSCNNGNNS
CCCCCCCCCCCCCCC		21.9428889911
1093PhosphorylationEQPQQHITSPQRFSE
HCCCCCCCCHHHHCC		32.0328889911
1094PhosphorylationQPQQHITSPQRFSES
CCCCCCCCHHHHCCC		20.5925752575
1138PhosphorylationQLRDVEESNFSTSPL
CCCCHHHCCCCCCCC		29.6622890988
1141PhosphorylationDVEESNFSTSPLRAD
CHHHCCCCCCCCCCC		32.0222890988
1142PhosphorylationVEESNFSTSPLRADY
HHHCCCCCCCCCCCC		30.1722890988
1143PhosphorylationEESNFSTSPLRADYG
HHCCCCCCCCCCCCC		22.2717330950
1149PhosphorylationTSPLRADYGNNIISS
CCCCCCCCCCCCCCC		22.2921440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YL278_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YL278_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YL278_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIR4_YEASTSIR4physical
16554755
GPG1_YEASTGPG1physical
16554755
SIR3_YEASTSIR3physical
16554755
IRC20_YEASTIRC20genetic
17314980
PFD2_YEASTGIM4genetic
17314980
MED5_YEASTNUT1genetic
17314980
PFD6_YEASTYKE2genetic
17314980
CSF1_YEASTCSF1genetic
17314980
GET2_YEASTGET2genetic
19325107
BUB3_YEASTBUB3genetic
20959818
HAP2_YEASTHAP2genetic
20959818
BUB1_YEASTBUB1genetic
20959818
PHD1_YEASTPHD1genetic
20959818
RXT2_YEASTRXT2genetic
20959818
RPA49_YEASTRPA49genetic
20959818
EAF5_YEASTEAF5genetic
20959818
SRD1_YEASTSRD1genetic
20959818
SPT23_YEASTSPT23genetic
20959818
AF9_YEASTYAF9genetic
20959818
IES1_YEASTIES1genetic
20959818
CCS1_YEASTCCS1genetic
20959818
DCC1_YEASTDCC1genetic
21127252
STB5_YEASTSTB5genetic
21127252
UPC2_YEASTUPC2genetic
21127252
MMS2_YEASTMMS2genetic
27708008
YRA2_YEASTYRA2genetic
27708008
NPL4_YEASTNPL4genetic
27708008
YD114_YEASTYDL114Wgenetic
27708008
TRM1_YEASTTRM1genetic
27708008
SWI5_YEASTSWI5genetic
27708008
TRM82_YEASTTRM82genetic
27708008
ODPA_YEASTPDA1genetic
27708008
PALF_YEASTRIM8genetic
27708008
DUR3_YEASTDUR3genetic
27708008
SODM_YEASTSOD2genetic
27708008
CRP1_YEASTCRP1genetic
27708008
YIA6_YEASTYIA6genetic
27708008
RM49_YEASTMRP49genetic
27708008
PALI_YEASTRIM9genetic
27708008
SRL1_YEASTSRL1genetic
27708008
MSC6_YEASTMSC6genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YL278_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1143, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-775; SER-796 ANDSER-1143, AND MASS SPECTROMETRY.

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