IRC20_YEAST - dbPTM
IRC20_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IRC20_YEAST
UniProt AC Q06554
Protein Name Uncharacterized ATP-dependent helicase IRC20
Gene Name IRC20
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1556
Subcellular Localization Nucleus .
Protein Description Is probably involved in a pathway contributing to genomic integrity..
Protein Sequence MSAVGALLAREYNVTAEKCDFFLENGSFDSVIAALPALNQEQETVTQKVSKNGKELINVASVNIEIPERISLSNNGRQLFKFIVDIEILPCENDNEATLVVSSDSVSLFQIGFKMENNSKIAVDKQLPLILDICAHKNQERALRNQLENRKSLERKPSRKRRKKNSNVNDPEKLLKSRIHELSLSYKDFECSPVVFRYNDSSLTWVLSFNLKLKFLNNKFNRFSVEANQILDLTFSNRDENEFERYHKHSHIHSNFIQKQFISQILEYSKDRLSKIKPFLPQSIPDLKVNLLPFQRESVEWMLIKEGHGNSLSDTPTVIDEVGLIDFMNEYYAYGYELIARSPDEVGPSLLWNKLTGYILTTEDAAHLYNQYRKERLSGDYPVCAKGVLAEEMGLGKTIEILSLILLNRRKLKDSEATFIDDENRTITKTKTTLIICPNAILKQWLEEIELHANSLKWYTYRGYNEIMKDCKTVDEAVQQLCQYDIIVTSYNIIATEVHHAEFNRSIRSRRLKSPKYDYSSPLALMQFYRIILDEVQMLRSSSTYSAKCTSLLHRIHTWGVSGTPIQNIYNFRMIMSYLKLHPFCDEVDFIRTLQEEIKLRNEAKDYTSNDFVCQLKGVRFSIKDCMNIFYRYDLCIRHSKANVASQIHIPRQHNFIIPLEFAPIEWDNYLNLWNNFLELSGYNSDGSGSPRVSNAFLNEWLSRLRYICCHALFPEILSTRQKRLHGHLSRISNIDDILISMRMDAFDSLIGYYRERFHLSIKQAQYELEISNTPAKALESFIKIRDDLMIHIRQKFNVEDPFDKSLNLSEDEDEHMDERFGEKETSSGDESDREINGAKNHDNHNNDGMLSNHLKKKGLRAMMNLLHDCYFFLGSVYYNLGTRKLEEADDKHRKEKTEEVVYSDVFPKNELEEIEENRLLEQENYANAEILRKSILSSEARKVDMTIKMARTKFAPMTSNIPLRLINIEFDHKNDYSSNLAVSRCFKSLSKLIEGLNEQTKNFNELLDELLIIIYEPVHRTEDDDSTNKIIGNEEYSTSIDSQDKIFSLLGCLEIILQNRDNILTSESEVKIPKHLVPEGSIISKYQKQLLNSLRLISGTPLRTVFDELKNSRIVRRISSSNESESTIQNFEDYLLQYEVESKSLFKYNKQVRESLKILGSIYNAKTEYYSQLQRISDSLVSLHSLSAPQLSHLIRTINKSLGGTLDAKINNIESRLIYLKNLSRLKDTLNDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLRAHSKCPICKGFCSISEVYNFKFKNSTEKREKEIQEPRREGADSSQDNSNENSIISNMSEVEKLFGNKYEQFHQINEVHQIHIKESFGAKIDFVIKLISYLRLKSEQENADPPQVILYSQKTEYLKVIGKVLKLYHIEHLACLSNTANVGETINNFKRQPSVTCLLLNVKTLGAGLNLINAKHIFLLDPILNNSDELQAMGRNNRIGQDEETFVWNFMIRNTVEENILRYKCILEERKRKEKSKKGDKYDEAQDETDNEESDDAKFEISVVDQEVSNEHLWNCFFHGSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSAVGALLA
------CCHHHHHHH		42.8622814378
73PhosphorylationIPERISLSNNGRQLF
CCCCEEECCCCCHHE		22.8130377154
298PhosphorylationLLPFQRESVEWMLIK
EECCCHHHEEEEEEE		27.7630377154
349PhosphorylationSPDEVGPSLLWNKLT
CCCCCCHHHHHHHCC		30.1127017623
415PhosphorylationNRRKLKDSEATFIDD
CCCCCCCCCCCEEEC		27.7827017623
426PhosphorylationFIDDENRTITKTKTT
EEECCCCEEEECEEE		44.5827017623
605UbiquitinationIKLRNEAKDYTSNDF
HHHHHHCCCCCCCCC		45.1223749301
806PhosphorylationVEDPFDKSLNLSEDE
CCCCCCCCCCCCCCC		25.0822369663
810PhosphorylationFDKSLNLSEDEDEHM
CCCCCCCCCCCCHHH		41.7622369663
826PhosphorylationERFGEKETSSGDESD
HHHCCCCCCCCCCCC		38.9821551504
827PhosphorylationRFGEKETSSGDESDR
HHCCCCCCCCCCCCC		33.1523749301
828PhosphorylationFGEKETSSGDESDRE
HCCCCCCCCCCCCCC		58.6521551504
832PhosphorylationETSSGDESDREINGA
CCCCCCCCCCCCCCC		46.8623749301
943AcetylationILSSEARKVDMTIKM
HHCHHHHHHCHHHHH		50.0325381059
949AcetylationRKVDMTIKMARTKFA
HHHCHHHHHHHHCCC		19.8325381059
1022PhosphorylationIYEPVHRTEDDDSTN
HCCCCCCCCCCCCCC		28.9627017623
1027PhosphorylationHRTEDDDSTNKIIGN
CCCCCCCCCCEEECC		40.6527017623
1028PhosphorylationRTEDDDSTNKIIGNE
CCCCCCCCCEEECCC		47.7427017623
1311PhosphorylationPRREGADSSQDNSNE
CHHCCCCCCCCCCCC		29.3930377154
1312PhosphorylationRREGADSSQDNSNEN
HHCCCCCCCCCCCCC		41.9423749301
1316PhosphorylationADSSQDNSNENSIIS
CCCCCCCCCCCCHHC		54.5323749301
1320PhosphorylationQDNSNENSIISNMSE
CCCCCCCCHHCCHHH		18.3421440633
1523PhosphorylationYDEAQDETDNEESDD
CCHHCCCCCCCCCCC		53.0328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IRC20_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IRC20_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IRC20_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H4_YEASTHHF1physical
11805837
H2A1_YEASTHTA1physical
11805837
EXO70_YEASTEXO70physical
11805837
YAP4_YEASTCIN5physical
11805837
MED5_YEASTNUT1genetic
17314980
MED2_YEASTMED2genetic
17314980
RSP5_YEASTRSP5genetic
17314980
DHE2_YEASTGDH2genetic
20093466
PEX19_YEASTPEX19genetic
20093466
PEX14_YEASTPEX14genetic
20093466
PEX8_YEASTPEX8genetic
20093466
RS21B_YEASTRPS21Bgenetic
20093466
PKR1_YEASTPKR1genetic
20093466
SSO2_YEASTSSO2genetic
20093466
MED9_YEASTCSE2genetic
20093466
SFL1_YEASTSFL1genetic
20093466
EXO1_YEASTEXO1genetic
22367032
UBI4P_YEASTUBI4physical
24155900
PYR1_YEASTURA2physical
24155900
VATB_YEASTVMA2physical
24155900
SSD1_YEASTSSD1physical
24155900
HSC82_YEASTHSC82physical
24155900
GLYC_YEASTSHM2physical
24155900
ALDH5_YEASTALD5physical
24155900
ARO1_YEASTARO1physical
24155900
PAT1_YEASTPAT1physical
24155900
SYDC_YEASTDPS1physical
24155900
RRP5_YEASTRRP5physical
24155900
PAN1_YEASTPAN1physical
24155900
ILV5_YEASTILV5physical
24155900
EAP1_YEASTEAP1physical
24155900
CDC48_YEASTCDC48physical
24155900
FBRL_YEASTNOP1physical
24155900
MAS5_YEASTYDJ1physical
24155900
NSR1_YEASTNSR1physical
24155900
ENO1_YEASTENO1physical
24155900
YHI0_YEASTYHR020Wphysical
24155900
ATPB_YEASTATP2physical
24155900
LSM2_YEASTLSM2physical
24155900
RPA1_YEASTRPA190physical
24155900
ARPC3_YEASTARC18physical
24155900
RUVB1_YEASTRVB1physical
24155900
LEUC_YEASTLEU1physical
24155900
RS23A_YEASTRPS23Aphysical
24155900
RS23B_YEASTRPS23Aphysical
24155900
NFS1_YEASTNFS1physical
24155900
PRP43_YEASTPRP43physical
24155900
DLD3_YEASTDLD3physical
24155900
IF2G_YEASTGCD11physical
24155900
NOP2_YEASTNOP2physical
24155900
IF4F2_YEASTTIF4632physical
24155900
TSL1_YEASTTSL1physical
24155900
YFI6_YEASTYFR016Cphysical
24155900
SMT3_YEASTSMT3physical
24155900
RL36A_YEASTRPL36Aphysical
24155900
PFKA2_YEASTPFK2physical
24155900
ADK_YEASTADO1physical
24155900
ARF2_YEASTARF2physical
24155900
RL13A_YEASTRPL13Aphysical
24155900
RL13B_YEASTRPL13Bphysical
24155900
ERF3_YEASTSUP35physical
24155900
DHAS_YEASTHOM2physical
24155900
H4_YEASTHHF1physical
24155900
VPH1_YEASTVPH1genetic
27708008
PEX19_YEASTPEX19genetic
27708008
UME6_YEASTUME6genetic
27708008
PEX14_YEASTPEX14genetic
27708008
DAL81_YEASTDAL81genetic
27708008
RS21B_YEASTRPS21Bgenetic
27708008
EF1G2_YEASTTEF4genetic
27708008
PKR1_YEASTPKR1genetic
27708008
SSO2_YEASTSSO2genetic
27708008
SFL1_YEASTSFL1genetic
27708008
MED1_YEASTMED1genetic
27708008
SCH9_YEASTSCH9genetic
27453043
GCN5_YEASTGCN5genetic
27453043
IRA2_YEASTIRA2genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IRC20_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-810, AND MASSSPECTROMETRY.

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