dbPTM

YFI6_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YFI6_YEAST
UniProt AC	P43597
Protein Name	Uncharacterized protein YFR016C
Gene Name	YFR016C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1233
Subcellular Localization
Protein Description
Protein Sequence	MVESLTVENQEHNVQPPSVTSAGDSYSTLATDLPLPSTNDIIESRDQLTESDLDEAINATENFAQELSSQRKSSKLKGHKKKNQGQIKANRDRDTIVKLSSSVGETEEASTRDAISHDLERKDDVIEIATDTINDATESPTQIPIDVNVVIKETSTNNVAEGTENVPPIKESTGIEVGNSPITRRKKNKKKKTTNRRGRNSSNPADTTDLSKQSTLDSILVGIEEYLQEDGSKNEDIKVNIVQDEPVNVEKMDIRTRNESSDKTFDIDVPNKDNVDETSSKSENNINEEKAEHTLPREENEILNVNEGNAASFKHQLEPHGLEAGDENGQASTKDVESESLTKNGFNFKENESKHLKAGEKQQTESDRDGISPSVLAKNQKETEIGKEDHVFEQKDKEDEKCRKELSVNHENNMSHNFNAAGSDSIIPPETERETYDDETMGPTKRISDNEKNLQHGTNDISVEVEKEEEEEEEEEENSTFSKVKKENVTGEQEAVRNNEVSGTEEESTSKGEEIMGGDEKQSEAGEKSSIIEIEGSANSAKISKDNLVLEDEAEAPTQENKPTEVVGEIDIPDAPRDDVEIVEAVEKNIIPEDLEVAKEDQEGEQVKLDEPVKAMKDDKIAMRGAESISEDMKKKQEGTAELSNEKAKKEVDETARESAEGVEVEKSKTPESPKVVKRCTSGRPEDLQINERDPEVLKEDVRVPDEDVKPEIATTIENSEEEDPKSQRVQISTEQAETTQKDMGDVGSTTSFKEEEKPKRFEITQEGDKITGKDTNHEHGEATEAASENSKASDVGTAEKYIEPSSESVKKDTEEDAEVENSEKTEFIKVKAELENLDAPKEAEVTAELNKENEDVEVDTEEDAEVENSEKTEFIKVKAELGNLDAPKEAEVTAELNKENEDVEVAATSKEDIETKCSEPAETPIEDGTCTEAEVSKKDAEAVTKEDENMENSKIAEALKDVTGDQEIDDINISDEFQRTVELPELEKQDIKDNKGEDKELEVEETEKETSLPDLVVEENITEEKNEIKQEEEEVSQLDFNETESISKEAPNNDENGFEDQSTRENPKKASADDIFKDILDETNEFLEQLKIVDDSELNALLQSLDAKDSTTQTTEQSKKNNDKPQDVITTSEIRKLNEKEPVYIYTSLAGGGFHMIPRTNRLSTILTANRIPFTYRDLGTDDEARKVWKTFSKGRSLPGVVRGHNDLIGNWEEIEEANEDYKLRELIYDTI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	IESRDQLTESDLDEA HHCCHHCCHHHHHHH	28.01	22369663
51	Phosphorylation	SRDQLTESDLDEAIN CCHHCCHHHHHHHHH	37.93	22369663
60	Phosphorylation	LDEAINATENFAQEL HHHHHHHHHHHHHHH	27.29	22369663
68	Phosphorylation	ENFAQELSSQRKSSK HHHHHHHHHHHHHHH	24.54	22369663
69	Phosphorylation	NFAQELSSQRKSSKL HHHHHHHHHHHHHHC	46.78	22369663
88	Acetylation	KKNQGQIKANRDRDT CCCCCCCCCCCCHHH	31.55	25381059
95	Phosphorylation	KANRDRDTIVKLSSS CCCCCHHHHHHHHCC	28.67	26447709
100	Phosphorylation	RDTIVKLSSSVGETE HHHHHHHHCCCCCCC	18.17	28889911
101	Phosphorylation	DTIVKLSSSVGETEE HHHHHHHCCCCCCCC	39.21	23749301
102	Phosphorylation	TIVKLSSSVGETEEA HHHHHHCCCCCCCCH	30.66	22369663
106	Phosphorylation	LSSSVGETEEASTRD HHCCCCCCCCHHHHH	32.95	26447709
110	Phosphorylation	VGETEEASTRDAISH CCCCCCHHHHHHHHH	27.53	26447709
111	Phosphorylation	GETEEASTRDAISHD CCCCCHHHHHHHHHH	39.35	26447709
137	Phosphorylation	TDTINDATESPTQIP HCCCCCCCCCCCCCC	39.60	28132839
139	Phosphorylation	TINDATESPTQIPID CCCCCCCCCCCCCCE	28.97	28889911
172	Phosphorylation	NVPPIKESTGIEVGN CCCCCCCCCCCCCCC	27.25	22890988
173	Phosphorylation	VPPIKESTGIEVGNS CCCCCCCCCCCCCCC	43.18	22890988
180	Phosphorylation	TGIEVGNSPITRRKK CCCCCCCCCCCCCCC	16.26	22369663
183	Phosphorylation	EVGNSPITRRKKNKK CCCCCCCCCCCCCCC	28.01	25521595
193	Phosphorylation	KKNKKKKTTNRRGRN CCCCCCCCCCCCCCC	37.88	21551504
201	Phosphorylation	TNRRGRNSSNPADTT CCCCCCCCCCCCCCC	30.08	22369663
202	Phosphorylation	NRRGRNSSNPADTTD CCCCCCCCCCCCCCC	50.83	22369663
207	Phosphorylation	NSSNPADTTDLSKQS CCCCCCCCCCHHHHH	25.06	22369663
208	Phosphorylation	SSNPADTTDLSKQST CCCCCCCCCHHHHHH	35.17	22369663
211	Phosphorylation	PADTTDLSKQSTLDS CCCCCCHHHHHHHHH	31.30	22369663
251	Acetylation	DEPVNVEKMDIRTRN CCCCCHHHEEEECCC	37.27	24489116
256	Phosphorylation	VEKMDIRTRNESSDK HHHEEEECCCCCCCC	37.87	24961812
260	Phosphorylation	DIRTRNESSDKTFDI EEECCCCCCCCEEEE	47.59	17287358
261	Phosphorylation	IRTRNESSDKTFDID EECCCCCCCCEEEEE	36.63	19779198
264	Phosphorylation	RNESSDKTFDIDVPN CCCCCCCEEEEECCC	31.37	29688323
278	Phosphorylation	NKDNVDETSSKSENN CCCCCCCCCCCCCCC	33.56	22369663
279	Phosphorylation	KDNVDETSSKSENNI CCCCCCCCCCCCCCC	33.45	22369663
280	Phosphorylation	DNVDETSSKSENNIN CCCCCCCCCCCCCCC	47.85	22369663
282	Phosphorylation	VDETSSKSENNINEE CCCCCCCCCCCCCHH	47.72	21440633
290	Acetylation	ENNINEEKAEHTLPR CCCCCHHHHHHCCCH	53.55	24489116
312	Phosphorylation	VNEGNAASFKHQLEP CCCCCHHHHHHHCCC	32.20	30377154
333	Phosphorylation	DENGQASTKDVESES CCCCCCCCCCCCCCC	33.99	25704821
334	Acetylation	ENGQASTKDVESESL CCCCCCCCCCCCCCC	58.23	24489116
340	Phosphorylation	TKDVESESLTKNGFN CCCCCCCCCCCCCCC	51.09	28889911
342	Phosphorylation	DVESESLTKNGFNFK CCCCCCCCCCCCCCC	31.57	27214570
364	Phosphorylation	KAGEKQQTESDRDGI CCCCCCCCHHHCCCC	34.66	22369663
366	Phosphorylation	GEKQQTESDRDGISP CCCCCCHHHCCCCCH	41.14	22369663
372	Phosphorylation	ESDRDGISPSVLAKN HHHCCCCCHHHHHHC	19.36	23749301
374	Phosphorylation	DRDGISPSVLAKNQK HCCCCCHHHHHHCCC	23.99	22369663
448	Phosphorylation	MGPTKRISDNEKNLQ CCCCCCCCCCCCCCC	38.12	28889911
458	Phosphorylation	EKNLQHGTNDISVEV CCCCCCCCCCCEEEE	27.82	19779198
462	Phosphorylation	QHGTNDISVEVEKEE CCCCCCCEEEEEHHH	18.32	28889911
479	Phosphorylation	EEEEEENSTFSKVKK HHHHHHHCCCCHHHH	33.82	28889911
490	Phosphorylation	KVKKENVTGEQEAVR HHHHHHCCCCHHHHH	46.73	22369663
502	Phosphorylation	AVRNNEVSGTEEEST HHHCCCCCCCCCCCC	33.54	22369663
504	Phosphorylation	RNNEVSGTEEESTSK HCCCCCCCCCCCCCC	32.49	21440633
508	Phosphorylation	VSGTEEESTSKGEEI CCCCCCCCCCCCCCC	41.06	22369663
509	Phosphorylation	SGTEEESTSKGEEIM CCCCCCCCCCCCCCC	37.42	22369663
510	Phosphorylation	GTEEESTSKGEEIMG CCCCCCCCCCCCCCC	48.20	22369663
521	Ubiquitination	EIMGGDEKQSEAGEK CCCCCCHHCCCCCCC	64.96	23749301
523	Phosphorylation	MGGDEKQSEAGEKSS CCCCHHCCCCCCCCC	40.25	22369663
529	Phosphorylation	QSEAGEKSSIIEIEG CCCCCCCCCCEEEEC	23.59	22369663
530	Phosphorylation	SEAGEKSSIIEIEGS CCCCCCCCCEEEECC	38.36	20377248
537	Phosphorylation	SIIEIEGSANSAKIS CCEEEECCCCCCCCC	16.10	22369663
540	Phosphorylation	EIEGSANSAKISKDN EEECCCCCCCCCCCC	30.56	22369663
544	Phosphorylation	SANSAKISKDNLVLE CCCCCCCCCCCEEEC	33.00	22369663
628	Phosphorylation	IAMRGAESISEDMKK HHHHCCHHHCHHHHH	30.77	23749301
640	Phosphorylation	MKKKQEGTAELSNEK HHHHHHCHHHHCHHH	19.06	27017623
644	Phosphorylation	QEGTAELSNEKAKKE HHCHHHHCHHHHHHH	34.15	28889911
655	Phosphorylation	AKKEVDETARESAEG HHHHHHHHHHHHHCC	26.93	24961812
659	Phosphorylation	VDETARESAEGVEVE HHHHHHHHHCCCCCC	26.52	22369663
668	Phosphorylation	EGVEVEKSKTPESPK CCCCCCCCCCCCCCH	28.40	22369663
670	Phosphorylation	VEVEKSKTPESPKVV CCCCCCCCCCCCHHH	39.10	22369663
673	Phosphorylation	EKSKTPESPKVVKRC CCCCCCCCCHHHHHC	31.09	22369663
681	Phosphorylation	PKVVKRCTSGRPEDL CHHHHHCCCCCHHHC	37.94	21440633
682	Phosphorylation	KVVKRCTSGRPEDLQ HHHHHCCCCCHHHCC	36.11	23749301
715	Phosphorylation	DVKPEIATTIENSEE CCCHHHCCCCCCCCC	33.69	20377248
716	Phosphorylation	VKPEIATTIENSEEE CCHHHCCCCCCCCCC	19.78	22369663
720	Phosphorylation	IATTIENSEEEDPKS HCCCCCCCCCCCCHH	33.33	22369663
727	Phosphorylation	SEEEDPKSQRVQIST CCCCCCHHHCEEEEH	28.71	26447709
734	Phosphorylation	SQRVQISTEQAETTQ HHCEEEEHHHHHHHC	33.47	24909858
749	Phosphorylation	KDMGDVGSTTSFKEE HHCCCCCCCCCCCCC	28.49	22369663
750	Phosphorylation	DMGDVGSTTSFKEEE HCCCCCCCCCCCCCC	22.11	22369663
751	Phosphorylation	MGDVGSTTSFKEEEK CCCCCCCCCCCCCCC	33.59	22369663
752	Phosphorylation	GDVGSTTSFKEEEKP CCCCCCCCCCCCCCC	34.12	22369663
758	Acetylation	TSFKEEEKPKRFEIT CCCCCCCCCCCEEEC	60.15	24489116
788	Phosphorylation	GEATEAASENSKASD CHHHHHHHHCCCCCC	44.34	21551504
791	Phosphorylation	TEAASENSKASDVGT HHHHHHCCCCCCCCC	26.08	21551504
794	Phosphorylation	ASENSKASDVGTAEK HHHCCCCCCCCCHHH	36.24	21551504
806	Phosphorylation	AEKYIEPSSESVKKD HHHHCCCCCHHHCCC	33.67	28889911
807	Phosphorylation	EKYIEPSSESVKKDT HHHCCCCCHHHCCCC	44.60	27017623
809	Phosphorylation	YIEPSSESVKKDTEE HCCCCCHHHCCCCHH	40.98	28889911
814	Phosphorylation	SESVKKDTEEDAEVE CHHHCCCCHHHHHHH	50.59	24961812
847	Phosphorylation	APKEAEVTAELNKEN CCCHHHHEHHHHCCC	13.11	22369663
861	Phosphorylation	NEDVEVDTEEDAEVE CCCCCCCCHHHHHHH	46.58	21551504
894	Phosphorylation	APKEAEVTAELNKEN CCCCHHEEEHHHCCC	13.11	22369663
910	Phosphorylation	DVEVAATSKEDIETK CCEEEEECHHHHHHH	29.35	28889911
919	Phosphorylation	EDIETKCSEPAETPI HHHHHHCCCCCCCCC	48.44	29136822
924	Phosphorylation	KCSEPAETPIEDGTC HCCCCCCCCCCCCCC	31.50	23749301
930	Phosphorylation	ETPIEDGTCTEAEVS CCCCCCCCCCEEECC	28.69	29136822
932	Phosphorylation	PIEDGTCTEAEVSKK CCCCCCCCEEECCHH	37.76	29136822
945	Phosphorylation	KKDAEAVTKEDENME HHHHHHHCCCHHHHH	35.45	22369663
954	Phosphorylation	EDENMENSKIAEALK CHHHHHHHHHHHHHH	16.48	22369663
975	Phosphorylation	EIDDINISDEFQRTV CCCCCCCCHHHHHHC	26.97	22369663
981	Phosphorylation	ISDEFQRTVELPELE CCHHHHHHCCCCHHH	13.93	24961812
1007	Phosphorylation	KELEVEETEKETSLP CCCEEECCCCCCCCC	38.56	27017623
1011	Phosphorylation	VEETEKETSLPDLVV EECCCCCCCCCCHHH	46.78	22369663
1012	Phosphorylation	EETEKETSLPDLVVE ECCCCCCCCCCHHHE	38.71	22369663
1023	Phosphorylation	LVVEENITEEKNEIK HHHEECCCHHHHHHH	50.07	22369663
1037	Phosphorylation	KQEEEEVSQLDFNET HHHHHHHHHCCCCCC	28.45	22369663
1044	Phosphorylation	SQLDFNETESISKEA HHCCCCCCCCCCCCC	35.82	22369663
1046	Phosphorylation	LDFNETESISKEAPN CCCCCCCCCCCCCCC	39.31	22369663
1048	Phosphorylation	FNETESISKEAPNND CCCCCCCCCCCCCCC	33.45	22369663
1072	Phosphorylation	RENPKKASADDIFKD CCCCCCCCHHHHHHH	40.90	22369663
1097	Phosphorylation	QLKIVDDSELNALLQ HCCCCCHHHHHHHHH	39.25	30377154
1105	Phosphorylation	ELNALLQSLDAKDST HHHHHHHHCCCCCCC	28.34	30377154
1125	Ubiquitination	QSKKNNDKPQDVITT HHHHCCCCCCCEEEH	46.86	23749301
1165	Phosphorylation	IPRTNRLSTILTANR CCCCCCCHHHHHHCC	15.34	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YFI6_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YFI6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YFI6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COFI_YEAST	COF1	physical	11805837
ODO1_YEAST	KGD1	physical	11805837
CAPZB_YEAST	CAP2	physical	11805837
CAPZA_YEAST	CAP1	physical	11805837
SSB1_YEAST	SSB1	physical	19536198
HSP72_YEAST	SSA2	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
HSP7F_YEAST	SSE1	physical	22940862
SSB1_YEAST	SSB1	physical	22940862
SWI6_YEAST	SWI6	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
RIM1_YEAST	RIM1	genetic	27708008
NUM1_YEAST	NUM1	genetic	27708008
RV167_YEAST	RVS167	genetic	27708008
BEM2_YEAST	BEM2	genetic	27708008
GOSR1_YEAST	GOS1	genetic	27708008
ICE2_YEAST	ICE2	genetic	27708008
DAL81_YEAST	DAL81	genetic	27708008
HIR3_YEAST	HIR3	genetic	27708008
CAPZA_YEAST	CAP1	genetic	27708008
LDB18_YEAST	LDB18	genetic	27708008
PMA2_YEAST	PMA2	genetic	27708008
YP066_YEAST	RGL1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YFI6_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-180; THR-183;SER-720; SER-749; THR-750; THR-751; SER-752; SER-809; THR-861;SER-975; SER-1046 AND SER-1072, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; THR-364; THR-670AND SER-673, AND MASS SPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-260, ANDMASS SPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, AND MASSSPECTROMETRY.	17330950 [Abstract]
"Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-673, AND MASSSPECTROMETRY.	11875433 [Abstract]