SWI6_YEAST - dbPTM
SWI6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SWI6_YEAST
UniProt AC P09959
Protein Name Regulatory protein SWI6
Gene Name SWI6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 803
Subcellular Localization Nucleus. Cytoplasm.
Protein Description Part of a complex involved in cell-cycle-dependent transcription. SWI4 and SWI6 are required for formation of the cell-cycle box factor-DNA complex. The repeated element in the upstream region of HO (5'-CACGAAAA-3') is called the cell cycle box (CCB)..
Protein Sequence MALEEVVRYLGPHNEIPLTLTRDSETGHFLLKHFLPILQQYHDTGNINETNPDSFPTDEERNKLLAHYGIAVNTDDRGELWIELEKCLQLLNMLNLFGLFQDAFEFEEPETDQDEEDPSHSKLPENKTKSENSKDNISSKRINNLQDMSLDSDAHRELGSPLKKLKIDTSVIDAESDSTPNTARGKPNDDINKGPSGDNENNGTDDNDRTAGPIITFTHDLTSDFLSSPLKIMKALPSPVVNDNEQKMKLEAFLQRLLFPEIQEMPTSLNNDSSNRNSEGGSSNQQQQHVSFDSLLQEVNDAFPNTQLNLNIPVDEHGNTPLHWLTSIANLELVKHLVKHGSNRLYGDNMGESCLVKAVKSVNNYDSGTFEALLDYLYPCLILEDSMNRTILHHIIITSGMTGCSAAAKYYLDILMGWIVKKQNRPIQSGTNEKESKPNDKNGERKDSILENLDLKWIIANMLNAQDSNGDTCLNIAARLGNISIVDALLDYGADPFIANKSGLRPVDFGAGTSKLQNTNGGDENSKMVSKGDYDGQKNGKAKKIRSQLLKNPPETTSLINDVQNLLNSISKDYENETVQYNEKLEKLHKELNEQREELANSREQLANVKQLKDEYSLMQEQLTNLKAGIEEEEESFREESKKLGIIADESSGIDWDSSEYDADEPFKVEFLSDFLEDKLQKNYEGDISKLLEAESKEQIMEQIRNQLPAEKIQSMLPPTVLLKARINAYKRNDKHLTNVLDTISTKQSELENKFRRVLSLCLKIDENKVDNMLDGLLQAISSEDPQDIDTDEMQDFLKKHAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationTLTRDSETGHFLLKH
EEECCCHHHHHHHHH		39.6527017623
111PhosphorylationFEFEEPETDQDEEDP
HHCCCCCCCCCCCCC		50.0723810556
130PhosphorylationLPENKTKSENSKDNI
CCCCCCCCCCCCCCC		47.4430377154
133PhosphorylationNKTKSENSKDNISSK
CCCCCCCCCCCCCCH		37.0223810556
134AcetylationKTKSENSKDNISSKR
CCCCCCCCCCCCCHH		67.3925381059
138PhosphorylationENSKDNISSKRINNL
CCCCCCCCCHHHHHH		35.7427017623
139PhosphorylationNSKDNISSKRINNLQ
CCCCCCCCHHHHHHH		23.3527017623
140AcetylationSKDNISSKRINNLQD
CCCCCCCHHHHHHHH		50.9725381059
149PhosphorylationINNLQDMSLDSDAHR
HHHHHHCCCCHHHHH		37.0019823750
152PhosphorylationLQDMSLDSDAHRELG
HHHCCCCHHHHHHHC		41.8321440633
160PhosphorylationDAHRELGSPLKKLKI
HHHHHHCCCCHHCCC		39.428590795
163AcetylationRELGSPLKKLKIDTS
HHHCCCCHHCCCCCE		60.4925381059
169PhosphorylationLKKLKIDTSVIDAES
CHHCCCCCEEEECCC		28.5022369663
170PhosphorylationKKLKIDTSVIDAESD
HHCCCCCEEEECCCC		17.2124909858
176PhosphorylationTSVIDAESDSTPNTA
CEEEECCCCCCCCCC		38.2822369663
178PhosphorylationVIDAESDSTPNTARG
EEECCCCCCCCCCCC		55.8522369663
179PhosphorylationIDAESDSTPNTARGK
EECCCCCCCCCCCCC		26.0822369663
182PhosphorylationESDSTPNTARGKPND
CCCCCCCCCCCCCCC		20.9522369663
196PhosphorylationDDINKGPSGDNENNG
CCCCCCCCCCCCCCC		68.4028889911
204PhosphorylationGDNENNGTDDNDRTA
CCCCCCCCCCCCCCC		42.1628889911
210PhosphorylationGTDDNDRTAGPIITF
CCCCCCCCCCCEEEE		38.5421551504
228PhosphorylationLTSDFLSSPLKIMKA
CCCHHHCCCHHHHHH		36.0821440633
238PhosphorylationKIMKALPSPVVNDNE
HHHHHCCCCCCCCCH		31.0428152593
267PhosphorylationPEIQEMPTSLNNDSS
HHHHHCCCCCCCCCC		44.5328889911
268PhosphorylationEIQEMPTSLNNDSSN
HHHHCCCCCCCCCCC		24.1928889911
273PhosphorylationPTSLNNDSSNRNSEG
CCCCCCCCCCCCCCC		31.4730377154
274PhosphorylationTSLNNDSSNRNSEGG
CCCCCCCCCCCCCCC		42.5523810556
502PhosphorylationDPFIANKSGLRPVDF
CCCCCCCCCCCCCCC		42.7523810556
514PhosphorylationVDFGAGTSKLQNTNG
CCCCCCCCCCCCCCC		30.3730377154
515UbiquitinationDFGAGTSKLQNTNGG
CCCCCCCCCCCCCCC		54.6623749301
526PhosphorylationTNGGDENSKMVSKGD
CCCCCCCCCCCCCCC		21.7823749301
530PhosphorylationDENSKMVSKGDYDGQ
CCCCCCCCCCCCCCC		27.6723810556
547PhosphorylationGKAKKIRSQLLKNPP
CCHHHHHHHHHHCCH		28.7520377248
557PhosphorylationLKNPPETTSLINDVQ
HHCCHHHHHHHHHHH		21.6312724400
602PhosphorylationQREELANSREQLANV
HHHHHHHCHHHHHHH		31.4223810556
617PhosphorylationKQLKDEYSLMQEQLT
HHHHHHHHHHHHHHH		18.4721440633
636PhosphorylationGIEEEEESFREESKK
CCHHHHHHHHHHHHH		32.6523749301
641PhosphorylationEESFREESKKLGIIA
HHHHHHHHHHHCCCC		30.2724961812
689PhosphorylationKNYEGDISKLLEAES
HHCCCCHHHHHHHHC		23.2223810556
715PhosphorylationLPAEKIQSMLPPTVL
CCHHHHHHCCCHHHH		26.2612724400
743PhosphorylationHLTNVLDTISTKQSE
HHHHHHHHHHHCHHH		16.8012724400
760PhosphorylationNKFRRVLSLCLKIDE
HHHHHHHHHHHHCCC		17.7430377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
160SPhosphorylationKinaseCDC28P00546
Uniprot
169TPhosphorylationKinaseRAD53P22216
GPS
170SPhosphorylationKinaseRAD53P22216
GPS
267TPhosphorylationKinaseRAD53P22216
GPS
547SPhosphorylationKinaseRAD53P22216
GPS
715SPhosphorylationKinaseRAD53P22216
GPS
743TPhosphorylationKinaseRAD53P22216
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SWI6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SWI6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HRR25_YEASTHRR25physical
9012827
STB1_YEASTSTB1physical
10409718
SWI4_YEASTSWI4physical
12024050
SLT2_YEASTSLT2physical
9065400
MBP1_YEASTMBP1physical
10512874
CG12_YEASTCLN2genetic
10545447
RME1_YEASTRME1genetic
10545447
SWI4_YEASTSWI4genetic
8423776
SWI4_YEASTSWI4genetic
2065973
TAF9_YEASTTAF9genetic
10747053
MED16_YEASTSIN4genetic
10713159
MED16_YEASTSIN4genetic
7935460
TRXB1_YEASTTRR1genetic
9202020
SPT16_YEASTSPT16genetic
7935460
WHI5_YEASTWHI5genetic
15210111
CG12_YEASTCLN2genetic
15454532
MED21_YEASTSRB7genetic
15998722
MED19_YEASTROX3genetic
15998722
MED16_YEASTSIN4genetic
15998722
MED5_YEASTNUT1genetic
15998722
SSN2_YEASTSSN2genetic
15998722
SSN3_YEASTSSN3genetic
15998722
MED3_YEASTPGD1genetic
15998722
MED1_YEASTMED1genetic
15998722
MED9_YEASTCSE2genetic
15998722
SRB8_YEASTSRB8genetic
15998722
MED20_YEASTSRB2genetic
15998722
MED18_YEASTSRB5genetic
15998722
PABP_YEASTPAB1genetic
15677747
ALF_YEASTFBA1genetic
15677747
GIN4_YEASTGIN4genetic
15677747
MSA2_YEASTMSA2physical
16554755
SWI4_YEASTSWI4physical
16429126
NRM1_YEASTNRM1physical
16916637
NAP1_YEASTNAP1genetic
17314980
DOA1_YEASTDOA1genetic
17314980
ELP2_YEASTELP2genetic
17314980
CTF8_YEASTCTF8genetic
17314980
SWI3_YEASTSWI3genetic
17314980
MNN10_YEASTMNN10genetic
17314980
RPN10_YEASTRPN10genetic
17314980
UBP6_YEASTUBP6genetic
17314980
SAC3_YEASTSAC3genetic
17314980
BRE1_YEASTBRE1genetic
17314980
SEM1_YEASTSEM1genetic
17314980
UBX1_YEASTSHP1genetic
17314980
PUS3_YEASTDEG1genetic
17314980
LRP1_YEASTLRP1genetic
17314980
ARD1_YEASTARD1genetic
17314980
RV161_YEASTRVS161genetic
17314980
MED31_YEASTSOH1genetic
17314980
DOT1_YEASTDOT1genetic
17314980
UBP13_YEASTUBP13genetic
17314980
RAD54_YEASTRAD54genetic
17314980
ELF1_YEASTELF1genetic
17314980
SWC5_YEASTSWC5genetic
17314980
SET4_YEASTSET4genetic
17314980
SRP40_YEASTSRP40genetic
17314980
BRE2_YEASTBRE2genetic
17314980
CHL4_YEASTCHL4genetic
17314980
RT107_YEASTRTT107genetic
17314980
RXT2_YEASTRXT2genetic
17314980
CWC26_YEASTBUD13genetic
17314980
SWC3_YEASTSWC3genetic
17314980
VPS8_YEASTVPS8genetic
17314980
GCN1_YEASTGCN1genetic
17314980
VPS64_YEASTVPS64genetic
17314980
UBR2_YEASTUBR2genetic
17314980
MSA1_YEASTMSA1physical
18160399
HSP7F_YEASTSSE1genetic
18478233
SWI4_YEASTSWI4genetic
18478233
HSP79_YEASTSSE2genetic
18478233
FES1_YEASTFES1genetic
18478233
NUP84_YEASTNUP84genetic
19269370
KCS1_YEASTKCS1genetic
19269370
IPK1_YEASTIPK1genetic
19269370
MCM21_YEASTMCM21genetic
19269370
SEM1_YEASTSEM1genetic
19269370
BMH1_YEASTBMH1genetic
19269370
MED31_YEASTSOH1genetic
19269370
KHSE_YEASTTHR1genetic
19269370
LRP1_YEASTLRP1genetic
19269370
CTF8_YEASTCTF8genetic
19269370
RPN10_YEASTRPN10genetic
19269370
CTK2_YEASTCTK2genetic
19269370
LSM1_YEASTLSM1genetic
19269370
FAR1_YEASTFAR1genetic
19269370
FEN1_YEASTRAD27genetic
19269370
DOA1_YEASTDOA1genetic
19269370
PSR2_YEASTPSR2genetic
19269370
SEC22_YEASTSEC22genetic
19269370
VIP1_YEASTVIP1genetic
19269370
RAD52_YEASTRAD52genetic
19269370
CTK3_YEASTCTK3genetic
19269370
PHO80_YEASTPHO80genetic
19269370
H2AZ_YEASTHTZ1genetic
19269370
PLC1_YEASTPLC1genetic
19269370
CG22_YEASTCLB2genetic
19269370
REV7_YEASTREV7genetic
19150335
SPT3_YEASTSPT3genetic
19547744
RPA14_YEASTRPA14genetic
19547744
ULS1_YEASTULS1genetic
19547744
RPN4_YEASTRPN4genetic
19547744
CHD1_YEASTCHD1genetic
19547744
SPT16_YEASTSPT16physical
19481521
POB3_YEASTPOB3physical
19481521
SPT16_YEASTSPT16physical
19745812
POB3_YEASTPOB3physical
19745812
NHP6A_YEASTNHP6Agenetic
9872947
NHP6B_YEASTNHP6Bgenetic
9872947
MSN1_YEASTMSN1genetic
9872947
SNF1_YEASTSNF1physical
20505334
RLM1_YEASTRLM1genetic
20865172
UGA3_YEASTUGA3genetic
20831804
MOT3_YEASTMOT3genetic
20959818
SWI4_YEASTSWI4genetic
20959818
SODC_YEASTSOD1genetic
20959818
SPT8_YEASTSPT8genetic
20959818
SKN7_YEASTSKN7genetic
20959818
AP1_YEASTYAP1genetic
20959818
SGF73_YEASTSGF73genetic
20959818
RPA14_YEASTRPA14genetic
20959818
DOA1_YEASTDOA1genetic
20959818
SPP1_YEASTSPP1genetic
20959818
LEO1_YEASTLEO1genetic
20959818
SAC3_YEASTSAC3genetic
20959818
ELP2_YEASTELP2genetic
20959818
CTF18_YEASTCTF18genetic
20959818
SEM1_YEASTSEM1genetic
20959818
EAF7_YEASTEAF7genetic
20959818
THI2_YEASTTHI2genetic
20959818
CTK1_YEASTCTK1genetic
20959818
PHO2_YEASTPHO2genetic
20959818
GCR2_YEASTGCR2genetic
20959818
POB3_YEASTPOB3genetic
19745812
CG11_YEASTCLN1genetic
19745812
CG12_YEASTCLN2genetic
19745812
CG11_YEASTCLN1genetic
10545447
SWI4_YEASTSWI4genetic
10545447
WHI3_YEASTWHI3genetic
15677747
RAD51_YEASTRAD51genetic
21127252
SUM1_YEASTSUM1genetic
21127252
RPN4_YEASTRPN4genetic
21127252
SWI4_YEASTSWI4genetic
21127252
UME6_YEASTUME6genetic
21127252
CTF8_YEASTCTF8genetic
21127252
DUN1_YEASTDUN1genetic
21127252
ELM1_YEASTELM1genetic
21127252
STB5_YEASTSTB5genetic
21127252
SNF1_YEASTSNF1genetic
21127252
YAK1_YEASTYAK1genetic
21127252
SERB_YEASTSER2genetic
21127252
VMS1_YEASTVMS1genetic
21127252
HSL1_YEASTHSL1genetic
21127252
MIG1_YEASTMIG1genetic
21127252
AKL1_YEASTAKL1genetic
21127252
BCK1_YEASTBCK1genetic
21127252
CIN8_YEASTCIN8genetic
22037179
MBP1_YEASTMBP1genetic
10512874
BCK1_YEASTBCK1genetic
22747505
SLT2_YEASTSLT2genetic
22747505
NUM1_YEASTNUM1physical
22875988
CG12_YEASTCLN2genetic
22889732
NRM1_YEASTNRM1physical
23593391
MBP1_YEASTMBP1physical
23593391
SWI4_YEASTSWI4physical
23593391
SNF1_YEASTSNF1physical
24084603
ESS1_YEASTESS1physical
24470217
UBI4P_YEASTUBI4genetic
15677747
WHI5_YEASTWHI5genetic
26310445
HIR1_YEASTHIR1genetic
26787838
HAP4_YEASTHAP4genetic
26787838
RTG1_YEASTRTG1genetic
26787838
ODPA_YEASTPDA1genetic
26787838
MPC1_YEASTMPC1genetic
26787838
CY1_YEASTCYT1genetic
26787838
SRL3_YEASTSRL3physical
28839131
SRL3_YEASTSRL3genetic
28839131
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SWI6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133; THR-169; SER-170;SER-176; SER-178; SER-228 AND THR-267, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160 AND SER-547, ANDMASS SPECTROMETRY.
"Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellularlocalization of Swi6.";
Geymonat M., Spanos A., Wells G.P., Smerdon S.J., Sedgwick S.G.;
Mol. Cell. Biol. 24:2277-2285(2004).
Cited for: PHOSPHORYLATION AT SER-160.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-179 AND THR-182, ANDMASS SPECTROMETRY.

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