MSA1_YEAST - dbPTM
MSA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSA1_YEAST
UniProt AC Q08471
Protein Name G1-specific transcription factors activator MSA1
Gene Name MSA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 629
Subcellular Localization
Protein Description Activator of G1-specific transcription factors, MBF and SBF. Promotes both the timing of G1-specific gene transcription and cell cycle initiation. Associates with SBF- and MBF-regulated target promoters and this binding is maximal during the G1 phase, prior to maximum budding. Affects cell cycle initiation by advancing the timing of transcription of G1-specific genes. Overexpression advances the timing of SBF-dependent transcription and budding. Depletion delays both indicators of cell cycle initiation..
Protein Sequence MDKSMIKKRGRPPITKDYPNPLQSPMAHSSMQVQKQGPHSFAKPLMKVGQSSPSPNKRRLSIDHHHNLAATTRKGRYRGVLLSTPTKKSSTNGSTPISTPSSNDSYNNTVFSETRKTFLQSSPPIMTSSPAFQKKNDYMFPSQEQFKLSLTITESGKAVIAGSLPFSPSSKSSHLMNNNNKKIMQNEKIHKGSKKNAPKFEKRRILSLLKQMKNEKYCDTDTLPEAPPAKPSRSDIIDTELPTIIETSASPIGSARNNNILLSQPPQSPPSSAQLKPPSTPKSSLQFRMGFTPNVALNSVSLSDTISKSTNAVGASNNNNQNGNSISNIADANTLLTLTNSPGVFLSPRNKMLPKSTTASNEQQQEFVFKFSSGDPLLLTDDADGNWPEMLFNVSNTPRRQKCFNTPPSWINFGSPGLFSPPRSSNVMVNGTTVATASDSGNVHRQLQAQLEAQVQVQSQSNSPTQRQQQQRQFQIPPPHINMNSSPPQINIASPPHQSMSRVSSIYFNKEKTTTGVANMLGNTKSENLQPPANLFTAAHGPSTPRNQEFQLPTLIECTPLIQQTMNGSLGTKYIPGTSISNSATPNLHGFPVGTGKAPSSFDDSLKQNPYSNKQDDARTALKRLIDDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
51PhosphorylationPLMKVGQSSPSPNKR
HHHHCCCCCCCCCCC		37.9827717283
52PhosphorylationLMKVGQSSPSPNKRR
HHHCCCCCCCCCCCC		22.8519684113
54PhosphorylationKVGQSSPSPNKRRLS
HCCCCCCCCCCCCCC		42.9519684113
121PhosphorylationTRKTFLQSSPPIMTS
HHHHHHHCCCCCCCC		47.1321082442
122PhosphorylationRKTFLQSSPPIMTSS
HHHHHHCCCCCCCCC		23.0221551504
163PhosphorylationGKAVIAGSLPFSPSS
CCEEEEECCCCCCCH		24.6928889911
167PhosphorylationIAGSLPFSPSSKSSH
EEECCCCCCCHHHHH		23.1821551504
169PhosphorylationGSLPFSPSSKSSHLM
ECCCCCCCHHHHHHC		49.5628132839
170PhosphorylationSLPFSPSSKSSHLMN
CCCCCCCHHHHHHCC		39.6828132839
234PhosphorylationPPAKPSRSDIIDTEL
CCCCCCHHHCCCCCC		37.1828889911
250PhosphorylationTIIETSASPIGSARN
CEEECCCCCCCCCCC		19.4728889911
254PhosphorylationTSASPIGSARNNNIL
CCCCCCCCCCCCCCC		25.4428132839
263PhosphorylationRNNNILLSQPPQSPP
CCCCCCCCCCCCCCC		36.8828132839
268PhosphorylationLLSQPPQSPPSSAQL
CCCCCCCCCCCCCCC		44.5519684113
271PhosphorylationQPPQSPPSSAQLKPP
CCCCCCCCCCCCCCC		41.5119684113
272PhosphorylationPPQSPPSSAQLKPPS
CCCCCCCCCCCCCCC		26.3028889911
279PhosphorylationSAQLKPPSTPKSSLQ
CCCCCCCCCCCCCEE		66.9123749301
280PhosphorylationAQLKPPSTPKSSLQF
CCCCCCCCCCCCEEE		40.2728889911
395PhosphorylationPEMLFNVSNTPRRQK
CHHHEECCCCCCHHH		35.7721440633
505PhosphorylationQSMSRVSSIYFNKEK
CCHHCCEEEEECCCC		20.6024909858
513PhosphorylationIYFNKEKTTTGVANM
EEECCCCCCCCHHHH		30.5929136822
514PhosphorylationYFNKEKTTTGVANML
EECCCCCCCCHHHHH		32.4029136822
515PhosphorylationFNKEKTTTGVANMLG
ECCCCCCCCHHHHHC		34.5929136822
524PhosphorylationVANMLGNTKSENLQP
HHHHHCCCCCCCCCC		33.8628889911
537PhosphorylationQPPANLFTAAHGPST
CCCCCEECCCCCCCC		26.5428132839
543PhosphorylationFTAAHGPSTPRNQEF
ECCCCCCCCCCCCCC		56.4922369663
544PhosphorylationTAAHGPSTPRNQEFQ
CCCCCCCCCCCCCCC		29.4222369663
601PhosphorylationGTGKAPSSFDDSLKQ
CCCCCCCCCCHHHHH		31.4728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SWI4_YEASTSWI4physical
18160399
MBP1_YEASTMBP1physical
18160399
ACH1_YEASTACH1genetic
20093466
BEM2_YEASTBEM2genetic
20093466
MAD1_YEASTMAD1genetic
20093466
MAD2_YEASTMAD2genetic
20093466
ELF1_YEASTELF1genetic
20093466
ZRC1_YEASTZRC1genetic
20093466
EOS1_YEASTEOS1genetic
20093466
MSB4_YEASTMSB4genetic
20093466
YPK9_YEASTYPK9genetic
20093466
CHL1_YEASTCHL1genetic
20093466
YP089_YEASTYPR089Wgenetic
20093466
KAR3_YEASTKAR3genetic
20093466
RNQ1_YEASTRNQ1genetic
22529103
TEC1_YEASTTEC1physical
24732795
STE12_YEASTSTE12physical
24732795
MBP1_YEASTMBP1physical
24732795
MSA2_YEASTMSA2genetic
24732795
TPS2_YEASTTPS2genetic
27708008
BEM2_YEASTBEM2genetic
27708008
ELF1_YEASTELF1genetic
27708008
VAC14_YEASTVAC14genetic
27708008
PEX12_YEASTPEX12genetic
27708008
ZRC1_YEASTZRC1genetic
27708008
OCA2_YEASTOCA2genetic
27708008
CHL1_YEASTCHL1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-234 ANDSER-601, AND MASS SPECTROMETRY.

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