VAC14_YEAST - dbPTM
VAC14_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VAC14_YEAST
UniProt AC Q06708
Protein Name Vacuole morphology and inheritance protein 14
Gene Name VAC14
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 880
Subcellular Localization Vacuole membrane
Peripheral membrane protein . Limiting membrane of the vacuole. Localization requires FAB1 and FIG4.
Protein Description The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization. Required for FIG4-mediated turnover of PtdIns(3,5)P2 after hyperosmotic shock. Essential for the control of trafficking of some proteins to the vacuole lumen via the multivesicular body (MVB), and for maintenance of vacuole size and acidity..
Protein Sequence MEKSIAKGLSDKLYEKRKAAALELEKLVKQCVLEGDYDRIDKIIDELCRDYAYALHQPMARNAGLMGLAATAIALGINDVGRYLRNILPPVLACFGDQNDQVRFYACESLYNIAKIAKGEILVYFNEIFDVLCKISADTENSVRGAAELLDRLIKDIVAERASNYISIVNNGSHGLLPAIKTDPISGDVYQEEYEQDNQLAFSLPKFIPLLTERIYAINPDTRVFLVDWLKVLLNTPGLELISYLPSFLGGLFTFLGDSHKDVRTVTHTLMDSLLHEVDRISKLQTEIKMKRLERLKMLEDKYNNSSTPTKKADGALIAEKKKTLMTALGGLSKPLSMETDDTKLSNTNETDDERHLTSQEQLLDSEATSQEPLRDGEEYIPGQDINLNFPEVITVLVNNLASSEAEIQLIALHWIQVILSISPNVFIPFLSKILSVLLKLLSDSDPHITEIAQLVNGQLLSLCSSYVGKETDGKIAYGPIVNSLTLQFFDSRIDAKIACLDWLILIYHKAPNQILKHNDSMFLTLLKSLSNRDSVLIEKALSLLQSLCSDSNDNYLRQFLQDLLTLFKRDTKLVKTRANFIMRQISSRLSPERVYKVISSILDNYNDTTFVKMMIQILSTNLITSPEMSSLRNKLRTCEDGMFFNSLFKSWCPNPVSVISLCFVAENYELAYTVLQTYANYELKLNDLVQLDILIQLFESPVFTRMRLQLLEQQKHPFLHKCLFGILMIIPQSKAFETLNRRLNSLNIWTSQSYVMNNYIRQRENSNFCDSNSDISQRSVSQSKLHFQELINHFKAVSEEDEYSSDMIRLDHGANNKSLLLGSFLDGIDEDKQEIVTPISPMNEAINEEMESPNDNSSVILKDSGSLPFNRNVSDKLKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
302UbiquitinationRLKMLEDKYNNSSTP
HHHHHHHHCCCCCCC		40.2723749301
303PhosphorylationLKMLEDKYNNSSTPT
HHHHHHHCCCCCCCC		31.7223749301
306PhosphorylationLEDKYNNSSTPTKKA
HHHHCCCCCCCCCCC		31.7630377154
307PhosphorylationEDKYNNSSTPTKKAD
HHHCCCCCCCCCCCC		40.3023749301
308PhosphorylationDKYNNSSTPTKKADG
HHCCCCCCCCCCCCC		34.4921082442
310PhosphorylationYNNSSTPTKKADGAL
CCCCCCCCCCCCCCC		45.3123749301
311AcetylationNNSSTPTKKADGALI
CCCCCCCCCCCCCCH		47.3625381059
337PhosphorylationGGLSKPLSMETDDTK
CCCCCCCCCCCCCCC		24.0921440633
340PhosphorylationSKPLSMETDDTKLSN
CCCCCCCCCCCCCCC		30.4527017623
351PhosphorylationKLSNTNETDDERHLT
CCCCCCCCCCHHHHC		51.3127214570
358PhosphorylationTDDERHLTSQEQLLD
CCCHHHHCCHHHHHC		23.4130377154
359PhosphorylationDDERHLTSQEQLLDS
CCHHHHCCHHHHHCC		37.7728889911
370PhosphorylationLLDSEATSQEPLRDG
HHCCCCCCCCCCCCC		39.3325704821
767PhosphorylationYIRQRENSNFCDSNS
HHHHHCCCCCCCCCC		26.9117563356
772PhosphorylationENSNFCDSNSDISQR
CCCCCCCCCCCCHHH		39.1423749301
774PhosphorylationSNFCDSNSDISQRSV
CCCCCCCCCCHHHHH		40.0328889911
777PhosphorylationCDSNSDISQRSVSQS
CCCCCCCHHHHHHHH		25.2423749301
780PhosphorylationNSDISQRSVSQSKLH
CCCCHHHHHHHHHHH		20.6223749301
782PhosphorylationDISQRSVSQSKLHFQ
CCHHHHHHHHHHHHH		29.9528889911
799PhosphorylationINHFKAVSEEDEYSS
HHHHHHCCCCCCCCC		39.8821440633
804PhosphorylationAVSEEDEYSSDMIRL
HCCCCCCCCCCCEEE		26.2919823750
805PhosphorylationVSEEDEYSSDMIRLD
CCCCCCCCCCCEEEC		20.1519823750
806PhosphorylationSEEDEYSSDMIRLDH
CCCCCCCCCCEEECC		30.2325752575
819PhosphorylationDHGANNKSLLLGSFL
CCCCCCCHHHHHHHC		26.7721551504
824PhosphorylationNKSLLLGSFLDGIDE
CCHHHHHHHCCCCCC		23.7021440633
841PhosphorylationQEIVTPISPMNEAIN
CCCCCCCCHHHHHHH		21.2121551504
853PhosphorylationAINEEMESPNDNSSV
HHHHHCCCCCCCCCE		27.9128889911
858PhosphorylationMESPNDNSSVILKDS
CCCCCCCCCEEEECC		28.9221551504
859PhosphorylationESPNDNSSVILKDSG
CCCCCCCCEEEECCC		21.3028889911
865PhosphorylationSSVILKDSGSLPFNR
CCEEEECCCCCCCCC		28.7921551504
867PhosphorylationVILKDSGSLPFNRNV
EEEECCCCCCCCCCH		36.5024961812
875PhosphorylationLPFNRNVSDKLKK--
CCCCCCHHHHHCC--		32.3620377248
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VAC14_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VAC14_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VAC14_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FIG4_YEASTFIG4physical
14528018
FAB1_YEASTFAB1genetic
12062051
YRA1_YEASTYRA1physical
16554755
VAC14_YEASTVAC14physical
18719252
2ABA_YEASTCDC55genetic
19269370
BCK1_YEASTBCK1genetic
19269370
OCA1_YEASTOCA1genetic
19269370
CLA4_YEASTCLA4genetic
19269370
INP53_YEASTINP53genetic
19269370
BECN1_YEASTVPS30genetic
19269370
HSP72_YEASTSSA2physical
19536198
VPS29_YEASTVPS29genetic
18931302
VPS35_YEASTVPS35genetic
18931302
SLT2_YEASTSLT2genetic
18931302
MNN10_YEASTMNN10genetic
18931302
PFD6_YEASTYKE2genetic
18931302
PFD3_YEASTPAC10genetic
18931302
VAC14_YEASTVAC14physical
19037259
VAC7_YEASTVAC7physical
19037259
FIG4_YEASTFIG4physical
19037259
FAB1_YEASTFAB1physical
19037259
MDM10_YEASTMDM10genetic
20093466
AVT5_YEASTAVT5genetic
20093466
GPT1_YEASTSCT1genetic
20093466
SLA1_YEASTSLA1genetic
20093466
PDR3_YEASTPDR3genetic
20093466
AIM4_YEASTAIM4genetic
20093466
CHK1_YEASTCHK1genetic
20093466
AP3M_YEASTAPM3genetic
20093466
BUD31_YEASTBUD31genetic
20093466
PAT1_YEASTPAT1genetic
20093466
CRD1_YEASTCRD1genetic
20093466
TRM3_YEASTTRM3genetic
20093466
GET3_YEASTGET3genetic
20093466
PRM7_YEASTPRM7genetic
20093466
MTU1_YEASTSLM3genetic
20093466
AIM7_YEASTAIM7genetic
20093466
SWI5_YEASTSWI5genetic
20093466
YD179_YEASTYDR179W-Agenetic
20093466
NUP42_YEASTNUP42genetic
20093466
MNN10_YEASTMNN10genetic
20093466
IPK1_YEASTIPK1genetic
20093466
MSN5_YEASTMSN5genetic
20093466
LCMT1_YEASTPPM1genetic
20093466
STP1_YEASTSTP1genetic
20093466
EMI1_YEASTEMI1genetic
20093466
GET2_YEASTGET2genetic
20093466
AIM11_YEASTAIM11genetic
20093466
BEM2_YEASTBEM2genetic
20093466
SPT2_YEASTSPT2genetic
20093466
BMH1_YEASTBMH1genetic
20093466
ATG18_YEASTATG18genetic
20093466
YGY5_YEASTYGL235Wgenetic
20093466
CWC26_YEASTBUD13genetic
20093466
AIM14_YEASTAIM14genetic
20093466
MON1_YEASTMON1genetic
20093466
VPS73_YEASTVPS73genetic
20093466
COG7_YEASTCOG7genetic
20093466
PEX31_YEASTPEX31genetic
20093466
UPF3_YEASTUPF3genetic
20093466
MALX3_YEASTIMA1genetic
20093466
OPI1_YEASTOPI1genetic
20093466
VPS29_YEASTVPS29genetic
20093466
SLT2_YEASTSLT2genetic
20093466
TOM71_YEASTTOM71genetic
20093466
ICE2_YEASTICE2genetic
20093466
MNN11_YEASTMNN11genetic
20093466
VPS35_YEASTVPS35genetic
20093466
LSM1_YEASTLSM1genetic
20093466
BCK1_YEASTBCK1genetic
20093466
PEP8_YEASTPEP8genetic
20093466
SNX4_YEASTSNX4genetic
20093466
CBF1_YEASTCBF1genetic
20093466
DCOR_YEASTSPE1genetic
20093466
EF1G2_YEASTTEF4genetic
20093466
RL14A_YEASTRPL14Agenetic
20093466
VPS51_YEASTVPS51genetic
20093466
TRM2_YEASTTRM2genetic
20093466
MLP1_YEASTMLP1genetic
20093466
LDB18_YEASTLDB18genetic
20093466
ARP6_YEASTARP6genetic
20093466
GIS3_YEASTGIS3genetic
20093466
SWI6_YEASTSWI6genetic
20093466
PFD6_YEASTYKE2genetic
20093466
ATP18_YEASTATP18genetic
20093466
BCH1_YEASTBCH1genetic
20093466
DYN3_YEASTDYN3genetic
20093466
MKS1_YEASTMKS1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
TLG2_YEASTTLG2genetic
20093466
MDM12_YEASTMDM12genetic
20093466
BUB3_YEASTBUB3genetic
20093466
ASE1_YEASTASE1genetic
20093466
GYP1_YEASTGYP1genetic
20093466
DIA2_YEASTDIA2genetic
20093466
FSH3_YEASTFSH3genetic
20093466
ENV7_YEASTENV7genetic
20093466
COX10_YEASTCOX10genetic
20093466
BECN1_YEASTVPS30genetic
20093466
YP066_YEASTRGL1genetic
20093466
EAF3_YEASTEAF3genetic
20093466
FAB1_YEASTFAB1physical
18653468
FIG4_YEASTFIG4physical
18653468
VAC14_YEASTVAC14physical
18653468
ATG18_YEASTATG18genetic
17699591
PP2C1_YEASTPTC1genetic
21127252
CTK2_YEASTCTK2genetic
21127252
SLT2_YEASTSLT2genetic
21127252
BCK1_YEASTBCK1genetic
21127252
OCA6_YEASTOCA6genetic
21127252
SET2_YEASTSET2genetic
21127252
RTG3_YEASTRTG3genetic
21127252
KCS1_YEASTKCS1genetic
21127252
EF1A_YEASTTEF2physical
22940862
HSP72_YEASTSSA2physical
22940862
VAC14_YEASTVAC14physical
22940862
HSP71_YEASTSSA1physical
22940862
BCK1_YEASTBCK1genetic
22282571
CHK1_YEASTCHK1genetic
22282571
VAC14_YEASTVAC14physical
23389034
FAB1_YEASTFAB1physical
23389034
FIG4_YEASTFIG4physical
23389034
FAB1_YEASTFAB1genetic
24478451
ATC3_YEASTDRS2genetic
27708008
IPK1_YEASTIPK1genetic
27708008
YFM7_YEASTYFR057Wgenetic
27708008
GET1_YEASTGET1genetic
27708008
VPS73_YEASTVPS73genetic
27708008
UPF3_YEASTUPF3genetic
27708008
NMD2_YEASTNMD2genetic
27708008
SNX4_YEASTSNX4genetic
27708008
CBF1_YEASTCBF1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
COG5_YEASTCOG5genetic
27708008
MET22_YEASTMET22genetic
27708008
RUD3_YEASTRUD3genetic
27708008
PDR3_YEASTPDR3genetic
27708008
SLA1_YEASTSLA1genetic
27708008
GPT1_YEASTSCT1genetic
27708008
AVT5_YEASTAVT5genetic
27708008
DPH7_YEASTRRT2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
MDHP_YEASTMDH3genetic
27708008
CRD1_YEASTCRD1genetic
27708008
AIM7_YEASTAIM7genetic
27708008
SWI5_YEASTSWI5genetic
27708008
SAC3_YEASTSAC3genetic
27708008
YD179_YEASTYDR179W-Agenetic
27708008
MNN10_YEASTMNN10genetic
27708008
LSM6_YEASTLSM6genetic
27708008
STP1_YEASTSTP1genetic
27708008
VPS72_YEASTVPS72genetic
27708008
BEM2_YEASTBEM2genetic
27708008
SPT2_YEASTSPT2genetic
27708008
BMH1_YEASTBMH1genetic
27708008
ATG18_YEASTATG18genetic
27708008
MRM2_YEASTMRM2genetic
27708008
AIM14_YEASTAIM14genetic
27708008
PFD3_YEASTPAC10genetic
27708008
OPI1_YEASTOPI1genetic
27708008
VPS29_YEASTVPS29genetic
27708008
SLT2_YEASTSLT2genetic
27708008
OSH3_YEASTOSH3genetic
27708008
TOM71_YEASTTOM71genetic
27708008
SDS3_YEASTSDS3genetic
27708008
BCK1_YEASTBCK1genetic
27708008
LSM1_YEASTLSM1genetic
27708008
MRX5_YEASTYJL147Cgenetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
MDM35_YEASTMDM35genetic
27708008
EF1G2_YEASTTEF4genetic
27708008
SMF3_YEASTSMF3genetic
27708008
ARP6_YEASTARP6genetic
27708008
GIS3_YEASTGIS3genetic
27708008
SWI6_YEASTSWI6genetic
27708008
PFD6_YEASTYKE2genetic
27708008
SIW14_YEASTSIW14genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
MKS1_YEASTMKS1genetic
27708008
PFD4_YEASTGIM3genetic
27708008
MDM12_YEASTMDM12genetic
27708008
ASE1_YEASTASE1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
FSH3_YEASTFSH3genetic
27708008
YP066_YEASTRGL1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
ENV7_YEASTENV7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VAC14_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-308; SER-805; SER-806;SER-853; SER-859 AND SER-867, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-767, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory