dbPTM

OSH3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OSH3_YEAST
UniProt AC	P38713
Protein Name	Oxysterol-binding protein homolog 3
Gene Name	OSH3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	996
Subcellular Localization	Cytoplasm . Enriched at the cell periphery in a SCS2-dependent manner.
Protein Description
Protein Sequence	METIDIQNRSFVVRWVKCGRGDVINYQIKPLKKSIEVGIYKKLKSSVDDHASAVHIAPDTKTLLDYTTKSLLHKGSSSNIEEHHRRSSQHSHSSSNGSDNKRKERSYSSLSISGIQQQSQEIPLREKLSASGFTLVKRVGNVSGNTMVQGDLEVKDTDYYYAFILDNSSSKNAKKKILFNASVINGDNQSMISTRSTPPARPTALSRTSTQQDMLFRVGQGRYLQGYLLKKRRKRLQGFKKRFFTLDFRYGTLSYYLNDHNQTCRGEIVISLSSVSANKKDKIIIIDSGMEVWVLKATTKENWQSWVDALQTCFDDQFEDKDTSTLEENPDILDDDKEVINKSSPQDHDHLTPTATTKSALSHRQHTQKDMDDIYVPLPSESYATFSMNLRLIQQRLEQCKKDSLSYKPTTLHQRSEGLNGTHSSSSVFTNNRVSSFNHSSSGMTSSDSLASEEVPSNKTYIEHALYNQLADLEVFVSRFVTQGEVLFKDHQILCKKAKDTRVSLTSYLSENDEFFDAEEEISRGVIILPDTEDDINNIVEETPLLGKSDQNEFTKEVQLSGSEQIASSSVESYTTNDENHSRKHLKNRHKNRRRGHPHHQKTKSAQSSTETFTSKDLFALSYPKSVTRRNDIPEAAASPPSLLSFLRKNVGKDLSSIAMPVTSNEPISILQLISETFEYAPLLTKATQRPDPITFVSAFAISFLSIYRDKTRTLRKPFNPLLAETFELIREDMGFRLISEKVSHRPPVFAFFAEHLDWECSYTVTPSQKFWGKSIELNNEGILRLKFKTTGELFEWTQPTTILKNLIAGERYMEPVNEFEVHSSKGDKSHILFDKAGMFSGRSEGFKVSIIPPPSSNRKKETLAGKWTQSLANETTHETIWEVGDLVSNPKKKYGFTKFTANLNEITEIEKGNLPPTDSRLRPDIRAYEEGNVDKAEEWKLKLEQLQRERRNKGQDVEPKYFEKVSKNEWKYITGPKSYWERRKKHDWSDISQLW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Ubiquitination	DVINYQIKPLKKSIE CCEEEEEECCCCEEE	28.86	17644757
32	Ubiquitination	NYQIKPLKKSIEVGI EEEEECCCCEEEEEC	53.66	17644757
33	Ubiquitination	YQIKPLKKSIEVGIY EEEECCCCEEEEECH	65.43	17644757
34	Phosphorylation	QIKPLKKSIEVGIYK EEECCCCEEEEECHH	23.53	28889911
45	Phosphorylation	GIYKKLKSSVDDHAS ECHHHHHHCCCCCCC	46.13	21440633
52	Phosphorylation	SSVDDHASAVHIAPD HCCCCCCCEEEECCC	27.66	21440633
69	Acetylation	TLLDYTTKSLLHKGS HHHHHHHHHHHHCCC	31.16	24489116
76	Phosphorylation	KSLLHKGSSSNIEEH HHHHHCCCCCCHHHH	35.08	23749301
77	Phosphorylation	SLLHKGSSSNIEEHH HHHHCCCCCCHHHHH	35.75	19779198
78	Phosphorylation	LLHKGSSSNIEEHHR HHHCCCCCCHHHHHH	43.45	19779198
87	Phosphorylation	IEEHHRRSSQHSHSS HHHHHHHHHCCCCCC	34.02	28889911
88	Phosphorylation	EEHHRRSSQHSHSSS HHHHHHHHCCCCCCC	30.05	26447709
91	Phosphorylation	HRRSSQHSHSSSNGS HHHHHCCCCCCCCCC	19.89	30377154
93	Phosphorylation	RSSQHSHSSSNGSDN HHHCCCCCCCCCCCC	38.18	26447709
94	Phosphorylation	SSQHSHSSSNGSDNK HHCCCCCCCCCCCCC	23.54	26447709
95	Phosphorylation	SQHSHSSSNGSDNKR HCCCCCCCCCCCCCC	48.50	30377154
98	Phosphorylation	SHSSSNGSDNKRKER CCCCCCCCCCCCCHH	42.11	30377154
106	Phosphorylation	DNKRKERSYSSLSIS CCCCCHHHHHHCEEC	30.38	22369663
107	Phosphorylation	NKRKERSYSSLSISG CCCCHHHHHHCEECC	14.43	22369663
108	Phosphorylation	KRKERSYSSLSISGI CCCHHHHHHCEECCH	26.50	22369663
109	Phosphorylation	RKERSYSSLSISGIQ CCHHHHHHCEECCHH	20.22	25521595
111	Phosphorylation	ERSYSSLSISGIQQQ HHHHHHCEECCHHHH	19.36	21440633
113	Phosphorylation	SYSSLSISGIQQQSQ HHHHCEECCHHHHCC	26.85	24961812
119	Phosphorylation	ISGIQQQSQEIPLRE ECCHHHHCCCCCHHH	25.99	19823750
190	Phosphorylation	VINGDNQSMISTRST EECCCCCCCEECCCC	25.08	25752575
193	Phosphorylation	GDNQSMISTRSTPPA CCCCCCEECCCCCCC	14.77	23749301
194	Phosphorylation	DNQSMISTRSTPPAR CCCCCEECCCCCCCC	20.08	23749301
196	Phosphorylation	QSMISTRSTPPARPT CCCEECCCCCCCCCC	45.41	23749301
197	Phosphorylation	SMISTRSTPPARPTA CCEECCCCCCCCCCC	29.96	21440633
203	Phosphorylation	STPPARPTALSRTST CCCCCCCCCCCCCCC	34.38	23749301
206	Phosphorylation	PARPTALSRTSTQQD CCCCCCCCCCCCCHH	30.92	23749301
208	Phosphorylation	RPTALSRTSTQQDML CCCCCCCCCCCHHHH	32.52	28889911
209	Phosphorylation	PTALSRTSTQQDMLF CCCCCCCCCCHHHHH	24.10	17330950
210	Phosphorylation	TALSRTSTQQDMLFR CCCCCCCCCHHHHHH	29.63	17330950
230	Acetylation	YLQGYLLKKRRKRLQ HHHHHHHHHHHHHHH	41.46	24489116
323	Phosphorylation	DQFEDKDTSTLEENP HHCCCCCCCCHHCCC	29.38	22890988
324	Phosphorylation	QFEDKDTSTLEENPD HCCCCCCCCHHCCCC	40.92	22890988
325	Phosphorylation	FEDKDTSTLEENPDI CCCCCCCCHHCCCCC	40.04	22890988
343	Phosphorylation	DKEVINKSSPQDHDH CHHHHHCCCCCCCCC	42.64	22890988
344	Phosphorylation	KEVINKSSPQDHDHL HHHHHCCCCCCCCCC	28.34	22890988
352	Phosphorylation	PQDHDHLTPTATTKS CCCCCCCCCCHHHHH	18.38	22369663
354	Phosphorylation	DHDHLTPTATTKSAL CCCCCCCCHHHHHHH	31.25	22890988
356	Phosphorylation	DHLTPTATTKSALSH CCCCCCHHHHHHHHC	36.92	22890988
357	Phosphorylation	HLTPTATTKSALSHR CCCCCHHHHHHHHCC	22.12	22890988
358	Ubiquitination	LTPTATTKSALSHRQ CCCCHHHHHHHHCCH	29.40	24961812
359	Phosphorylation	TPTATTKSALSHRQH CCCHHHHHHHHCCHH	32.14	23749301
362	Phosphorylation	ATTKSALSHRQHTQK HHHHHHHHCCHHCCC	19.15	23749301
402	Ubiquitination	QRLEQCKKDSLSYKP HHHHHHHHCCCCCCC	61.24	17644757
408	Ubiquitination	KKDSLSYKPTTLHQR HHCCCCCCCCCHHHC	32.29	17644757
416	Phosphorylation	PTTLHQRSEGLNGTH CCCHHHCCCCCCCCC	29.46	30377154
422	Phosphorylation	RSEGLNGTHSSSSVF CCCCCCCCCCCCCCC	19.94	22369663
424	Phosphorylation	EGLNGTHSSSSVFTN CCCCCCCCCCCCCCC	31.58	22369663
425	Phosphorylation	GLNGTHSSSSVFTNN CCCCCCCCCCCCCCC	21.01	22369663
426	Phosphorylation	LNGTHSSSSVFTNNR CCCCCCCCCCCCCCC	33.27	22369663
427	Phosphorylation	NGTHSSSSVFTNNRV CCCCCCCCCCCCCCC	24.17	22369663
430	Phosphorylation	HSSSSVFTNNRVSSF CCCCCCCCCCCCCCC	29.45	23749301
435	Phosphorylation	VFTNNRVSSFNHSSS CCCCCCCCCCCCCCC	26.44	30377154
436	Phosphorylation	FTNNRVSSFNHSSSG CCCCCCCCCCCCCCC	27.49	27017623
440	Phosphorylation	RVSSFNHSSSGMTSS CCCCCCCCCCCCCCC	27.57	30377154
441	Phosphorylation	VSSFNHSSSGMTSSD CCCCCCCCCCCCCCC	24.30	29688323
442	Phosphorylation	SSFNHSSSGMTSSDS CCCCCCCCCCCCCCC	35.28	19779198
445	Phosphorylation	NHSSSGMTSSDSLAS CCCCCCCCCCCCCCC	28.71	23749301
446	Phosphorylation	HSSSGMTSSDSLASE CCCCCCCCCCCCCCC	24.21	23749301
447	Phosphorylation	SSSGMTSSDSLASEE CCCCCCCCCCCCCCC	23.27	25752575
449	Phosphorylation	SGMTSSDSLASEEVP CCCCCCCCCCCCCCC	27.99	17330950
452	Phosphorylation	TSSDSLASEEVPSNK CCCCCCCCCCCCCCC	39.31	17330950
457	Phosphorylation	LASEEVPSNKTYIEH CCCCCCCCCCHHHHH	57.01	29688323
459	Ubiquitination	SEEVPSNKTYIEHAL CCCCCCCCHHHHHHH	47.22	17644757
489	Ubiquitination	TQGEVLFKDHQILCK CCCCEEEECCEEEEE	50.57	17644757
496	Ubiquitination	KDHQILCKKAKDTRV ECCEEEEECCCCCCE	52.93	17644757
497	Ubiquitination	DHQILCKKAKDTRVS CCEEEEECCCCCCEE	60.72	17644757
510	Phosphorylation	VSLTSYLSENDEFFD EEEEHCCCCCCCCCC	26.56	29650682
532	Phosphorylation	GVIILPDTEDDINNI CEEECCCCHHHHHHH	39.10	23749301
543	Phosphorylation	INNIVEETPLLGKSD HHHHHHHCCCCCCCC	13.01	23749301
548	Ubiquitination	EETPLLGKSDQNEFT HHCCCCCCCCCCCCC	51.32	23749301
561	Phosphorylation	FTKEVQLSGSEQIAS CCCEEEECCCHHHCC	24.15	23749301
582	Phosphorylation	TTNDENHSRKHLKNR CCCCCCCCHHHHHHH	55.39	23749301
603	Phosphorylation	GHPHHQKTKSAQSST CCCCCHHCCCCCCCC	24.54	22369663
604	Ubiquitination	HPHHQKTKSAQSSTE CCCCHHCCCCCCCCC	51.32	17644757
605	Phosphorylation	PHHQKTKSAQSSTET CCCHHCCCCCCCCCE	36.45	22369663
608	Phosphorylation	QKTKSAQSSTETFTS HHCCCCCCCCCEECH	38.66	22369663
609	Phosphorylation	KTKSAQSSTETFTSK HCCCCCCCCCEECHH	20.41	22369663
610	Phosphorylation	TKSAQSSTETFTSKD CCCCCCCCCEECHHH	44.27	22369663
612	Phosphorylation	SAQSSTETFTSKDLF CCCCCCCEECHHHHE	32.09	22369663
614	Phosphorylation	QSSTETFTSKDLFAL CCCCCEECHHHHEEC	42.14	27717283
615	Phosphorylation	SSTETFTSKDLFALS CCCCEECHHHHEECC	21.71	27717283
616	Ubiquitination	STETFTSKDLFALSY CCCEECHHHHEECCC	56.23	17644757
628	Phosphorylation	LSYPKSVTRRNDIPE CCCCCCCCCCCCCCH	30.88	21440633
649	Ubiquitination	SLLSFLRKNVGKDLS HHHHHHHHHCCCCHH	59.12	17644757
787	Ubiquitination	NEGILRLKFKTTGEL CCCEEEEEEEECCCC	38.08	17644757
789	Ubiquitination	GILRLKFKTTGELFE CEEEEEEEECCCCEE	43.52	17644757
805	Ubiquitination	TQPTTILKNLIAGER CCCHHHHHHHHCCCC	45.95	17644757
829	Ubiquitination	VHSSKGDKSHILFDK EECCCCCCCEEEEEC	53.23	17644757
830	Phosphorylation	HSSKGDKSHILFDKA ECCCCCCCEEEEECC	22.09	28889911
836	Ubiquitination	KSHILFDKAGMFSGR CCEEEEECCCCCCCC	39.23	17644757
856	Phosphorylation	VSIIPPPSSNRKKET EEEECCCCCCCCCCC	46.12	19779198
857	Phosphorylation	SIIPPPSSNRKKETL EEECCCCCCCCCCCC	46.56	19779198
869	Phosphorylation	ETLAGKWTQSLANET CCCCCHHHHHHCCCC	16.27	19823750
871	Phosphorylation	LAGKWTQSLANETTH CCCHHHHHHCCCCCC	23.29	19823750
876	Phosphorylation	TQSLANETTHETIWE HHHHCCCCCCCCHHH	33.01	19823750
877	Phosphorylation	QSLANETTHETIWEV HHHCCCCCCCCHHHH	16.13	19823750
880	Phosphorylation	ANETTHETIWEVGDL CCCCCCCCHHHHHHH	24.64	19823750
889	Phosphorylation	WEVGDLVSNPKKKYG HHHHHHHCCCCHHCC	55.50	19823750
895	Phosphorylation	VSNPKKKYGFTKFTA HCCCCHHCCCEEEEE	26.76	21440633
898	Phosphorylation	PKKKYGFTKFTANLN CCHHCCCEEEEEEHH	22.38	21440633
990	Phosphorylation	RRKKHDWSDISQLW- HHHHCCCCHHHHCC-	30.99	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of OSH3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of OSH3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OSH3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOP4_YEAST	NOP4	physical	11805837
RRS1_YEAST	RRS1	physical	16554755
QCR2_YEAST	QCR2	physical	16554755
KES1_YEAST	KES1	genetic	11238399
SAC1_YEAST	SAC1	physical	21295699
KES1_YEAST	KES1	genetic	21819498
SCS2_YEAST	SCS2	physical	24366873
SCS22_YEAST	SCS22	physical	24366873
SEC22_YEAST	SEC22	physical	24705552
SSO1_YEAST	SSO1	physical	24705552
BUD31_YEAST	BUD31	genetic	27708008
IMG2_YEAST	IMG2	genetic	27708008
YD199_YEAST	YDL199C	genetic	27708008
OST4_YEAST	OST4	genetic	27708008
ADR1_YEAST	ADR1	genetic	27708008
RL19A_YEAST	RPL19B	genetic	27708008
RL19B_YEAST	RPL19B	genetic	27708008
PP2C3_YEAST	PTC3	genetic	27708008
H3_YEAST	HHT1	genetic	27708008
ADPP_YEAST	YSA1	genetic	27708008
AIM4_YEAST	AIM4	genetic	27708008
DUR1_YEAST	DUR1,2	genetic	27708008
AGP1_YEAST	AGP1	genetic	27708008
RV161_YEAST	RVS161	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
BRE1_YEAST	BRE1	genetic	27708008
RL35A_YEAST	RPL35A	genetic	27708008
RL35B_YEAST	RPL35A	genetic	27708008
CSN5_YEAST	RRI1	genetic	27708008
RTN1_YEAST	RTN1	genetic	27708008
MNN10_YEAST	MNN10	genetic	27708008
IES5_YEAST	IES5	genetic	27708008
PT122_YEAST	PET122	genetic	27708008
SPO74_YEAST	SPO74	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
CHO2_YEAST	CHO2	genetic	27708008
QCR9_YEAST	QCR9	genetic	27708008
DAL81_YEAST	DAL81	genetic	27708008
CBF1_YEAST	CBF1	genetic	27708008
FEN1_YEAST	RAD27	genetic	27708008
COX12_YEAST	COX12	genetic	27708008
PDE2_YEAST	PDE2	genetic	27708008
MRX11_YEAST	YPL041C	genetic	27708008
YAR1_YEAST	YAR1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OSH3_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-107; THR-197; SER-209;THR-210; THR-422; THR-603; SER-605; SER-608; SER-609 AND THR-610, ANDMASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-352, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-352, AND MASSSPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-210, AND MASSSPECTROMETRY.	17330950 [Abstract]