| UniProt ID | CHO2_YEAST | |
|---|---|---|
| UniProt AC | P05374 | |
| Protein Name | Phosphatidylethanolamine N-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03217, ECO:0000303|PubMed:2445736} | |
| Gene Name | CHO2 {ECO:0000303|PubMed:3066687} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 869 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME). Preferentially converts di-C16:1 substrates.. | |
| Protein Sequence | MSSCKTTLSEMVGSVTKDRGTINVEARTRSSNVTFKPPVTHDMVRSLFDPTLKKSLLEKCIALAIISNFFICYWVFQRFGLQFTKYFFLVQYLFWRIAYNLGIGLVLHYQSHYETLTNCAKTHAIFSKIPQNKDANSNFSTNSNSFSEKFWNFIRKFCQYEIRSKMPKEYDLFAYPEEINVWLIFRQFVDLILMQDFVTYIIYVYLSIPYSWVQIFNWRSLLGVILILFNIWVKLDAHRVVKDYAWYWGDFFFLEESELIFDGVFNISPHPMYSIGYLGYYGLSLICNDYKVLLVSVFGHYSQFLFLKYVENPHIERTYGDGTDSDSQMNSRIDDLISKENYDYSRPLINMGLSFNNFNKLRFTDYFTIGTVAALMLGTIMNARFINLNYLFITVFVTKLVSWLFISTILYKQSQSKWFTRLFLENGYTQVYSYEQWQFIYNYYLVLTYTLMIIHTGLQIWSNFSNINNSQLIFGLILVALQTWCDKETRLAISDFGWFYGDFFLSNYISTRKLTSQGIYRYLNHPEAVLGVVGVWGTVLMTNFAVTNIILAVLWTLTNFILVKFIETPHVNKIYGKTKRVSGVGKTLLGLKPLRQVSDIVNRIENIIIKSLVDESKNSNGGAELLPKNYQDNKEWNILIQEAMDSVATRLSPYCELKIENEQVETNFVLPTPVTLNWKMPIELYNGDDWIGLYKVIDTRADREKTRVGSGGHWSATSKDSYMNHGLRHKESVTEIKATEKYVQGKVTFDTSLLYFENGIYEFRYHSGNSHKVLLISTPFEISLPVLNTTTPELFEKDLTEFLTKVNVLKDGKFRPLGNKFFGMDSLKQLIKNSIGVELSSEYMRRVNGDAHVISHRAWDIKQTLDSLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSSCKTTLS ------CCCCCCCHH | 44.43 | 22814378 | |
| 5 | Ubiquitination | ---MSSCKTTLSEMV ---CCCCCCCHHHHH | 46.63 | 17644757 | |
| 9 | Phosphorylation | SSCKTTLSEMVGSVT CCCCCCHHHHHCCEE | 22.89 | 21440633 | |
| 14 | Phosphorylation | TLSEMVGSVTKDRGT CHHHHHCCEECCCCE | 18.40 | 22369663 | |
| 16 | Phosphorylation | SEMVGSVTKDRGTIN HHHHCCEECCCCEEE | 29.00 | 22369663 | |
| 17 | Ubiquitination | EMVGSVTKDRGTINV HHHCCEECCCCEEEE | 43.18 | 24961812 | |
| 36 | Acetylation | RSSNVTFKPPVTHDM CCCCCEECCCCCHHH | 38.76 | 24489116 | |
| 36 | Ubiquitination | RSSNVTFKPPVTHDM CCCCCEECCCCCHHH | 38.76 | 17644757 | |
| 121 | Ubiquitination | ETLTNCAKTHAIFSK HHHHHHHHHHHHHHC | 42.94 | 17644757 | |
| 128 | Acetylation | KTHAIFSKIPQNKDA HHHHHHHCCCCCCCC | 47.89 | 24489116 | |
| 128 | Ubiquitination | KTHAIFSKIPQNKDA HHHHHHHCCCCCCCC | 47.89 | 17644757 | |
| 133 | Acetylation | FSKIPQNKDANSNFS HHCCCCCCCCCCCCC | 53.63 | 24489116 | |
| 133 | Ubiquitination | FSKIPQNKDANSNFS HHCCCCCCCCCCCCC | 53.63 | 23749301 | |
| 149 | Ubiquitination | NSNSFSEKFWNFIRK CCCHHHHHHHHHHHH | 55.25 | 17644757 | |
| 156 | Ubiquitination | KFWNFIRKFCQYEIR HHHHHHHHHHHHHHH | 45.75 | 17644757 | |
| 318 | Phosphorylation | ENPHIERTYGDGTDS CCCCEEEECCCCCCC | 21.04 | 22369663 | |
| 323 | Phosphorylation | ERTYGDGTDSDSQMN EEECCCCCCCHHHHH | 36.75 | 22369663 | |
| 325 | Phosphorylation | TYGDGTDSDSQMNSR ECCCCCCCHHHHHHH | 38.71 | 22369663 | |
| 327 | Phosphorylation | GDGTDSDSQMNSRID CCCCCCHHHHHHHHH | 34.97 | 22369663 | |
| 331 | Phosphorylation | DSDSQMNSRIDDLIS CCHHHHHHHHHHHHH | 25.85 | 22369663 | |
| 513 | Ubiquitination | SNYISTRKLTSQGIY HHHCCCCCCCHHHHH | 57.09 | 23749301 | |
| 582 | Phosphorylation | YGKTKRVSGVGKTLL CCCCEECCCCCHHHH | 31.62 | 17563356 | |
| 586 | Ubiquitination | KRVSGVGKTLLGLKP EECCCCCHHHHCCCC | 33.33 | 24961812 | |
| 587 | Phosphorylation | RVSGVGKTLLGLKPL ECCCCCHHHHCCCCH | 22.68 | 22369663 | |
| 592 | Acetylation | GKTLLGLKPLRQVSD CHHHHCCCCHHHHHH | 39.96 | 24489116 | |
| 592 | Ubiquitination | GKTLLGLKPLRQVSD CHHHHCCCCHHHHHH | 39.96 | 24961812 | |
| 598 | Phosphorylation | LKPLRQVSDIVNRIE CCCHHHHHHHHHHHH | 17.18 | 30377154 | |
| 610 | Acetylation | RIENIIIKSLVDESK HHHHHHHHHHHCCCC | 27.59 | 24489116 | |
| 610 | Ubiquitination | RIENIIIKSLVDESK HHHHHHHHHHHCCCC | 27.59 | 17644757 | |
| 617 | Acetylation | KSLVDESKNSNGGAE HHHHCCCCCCCCCCC | 63.45 | 24489116 | |
| 617 | Ubiquitination | KSLVDESKNSNGGAE HHHHCCCCCCCCCCC | 63.45 | 17644757 | |
| 628 | Ubiquitination | GGAELLPKNYQDNKE CCCCCCCCCCCCCHH | 69.15 | 17644757 | |
| 634 | Ubiquitination | PKNYQDNKEWNILIQ CCCCCCCHHHHHHHH | 72.84 | 17644757 | |
| 658 | Ubiquitination | LSPYCELKIENEQVE HCCCCEEEECCEEEE | 26.19 | 17644757 | |
| 679 | Ubiquitination | TPVTLNWKMPIELYN CCEEEEEECEEEEEC | 33.45 | 17644757 | |
| 695 | Ubiquitination | DDWIGLYKVIDTRAD CCEEEEEEEEECCCC | 37.44 | 17644757 | |
| 706 | Phosphorylation | TRADREKTRVGSGGH CCCCHHCCCCCCCCC | 26.32 | 19823750 | |
| 710 | Phosphorylation | REKTRVGSGGHWSAT HHCCCCCCCCCCCCC | 38.45 | 23749301 | |
| 719 | Ubiquitination | GHWSATSKDSYMNHG CCCCCCCCHHHHCCC | 46.46 | 17644757 | |
| 719 | Acetylation | GHWSATSKDSYMNHG CCCCCCCCHHHHCCC | 46.46 | 24489116 | |
| 730 | Ubiquitination | MNHGLRHKESVTEIK HCCCCCCCCCHHHHH | 45.29 | 17644757 | |
| 734 | Phosphorylation | LRHKESVTEIKATEK CCCCCCHHHHHCCCC | 41.07 | 28889911 | |
| 737 | Ubiquitination | KESVTEIKATEKYVQ CCCHHHHHCCCCHHC | 42.92 | 17644757 | |
| 741 | Ubiquitination | TEIKATEKYVQGKVT HHHHCCCCHHCCEEE | 46.49 | 23749301 | |
| 746 | Ubiquitination | TEKYVQGKVTFDTSL CCCHHCCEEEECCEE | 22.47 | 17644757 | |
| 772 | Ubiquitination | YHSGNSHKVLLISTP EECCCCCEEEEEECC | 34.11 | 17644757 | |
| 797 | Ubiquitination | TTPELFEKDLTEFLT CCHHHHHCHHHHHHH | 51.18 | 17644757 | |
| 805 | Ubiquitination | DLTEFLTKVNVLKDG HHHHHHHHHCCCCCC | 33.68 | 24961812 | |
| 805 | Acetylation | DLTEFLTKVNVLKDG HHHHHHHHHCCCCCC | 33.68 | 24489116 | |
| 820 | Ubiquitination | KFRPLGNKFFGMDSL CEECCCCHHCCHHHH | 40.03 | 17644757 | |
| 820 | Acetylation | KFRPLGNKFFGMDSL CEECCCCHHCCHHHH | 40.03 | 24489116 | |
| 828 | Ubiquitination | FFGMDSLKQLIKNSI HCCHHHHHHHHHHCC | 47.19 | 17644757 | |
| 828 | Acetylation | FFGMDSLKQLIKNSI HCCHHHHHHHHHHCC | 47.19 | 24489116 | |
| 832 | Ubiquitination | DSLKQLIKNSIGVEL HHHHHHHHHCCCCCC | 53.91 | 23749301 | |
| 862 | Ubiquitination | SHRAWDIKQTLDSLA HHHHHCHHHHHHHHC | 34.45 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CHO2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CHO2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CHO2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-582, AND MASSSPECTROMETRY. | |
