PNS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PNS1_YEAST
• UniProt AC: Q12412
• Protein Name: Protein PNS1
• Gene Name: PNS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 539
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Probably involved in transport through the plasma membrane..
• Protein Sequence: MPLNEKYERPPQPPPAYDPNHRPPSSSENSAAANVNDGQTPYHFRQDQYYNLNSKTSGAPIGSFDEAFPTENDNKPRWNDWPFTIFFLCTVGGFIAIAAITLRAWSQTYSSTGSGIYDGVNTGTLNTNAAILLVFVCIIALVFSVLGLTLCRIFPKQFIYCGMVINLVASLGTAIMYMSLRYWSAGIVFLVFTFMTAWCYWGMRSRIPLSVAVLKVVVDAMKKCPQIFFVSFVGALVASAFGFLFSAVIVATYIKYDPNSSNGGCDVSGGSCSHSKLIGVLVVVFFCGYYISEVIRNVIHCVISGVFGSWYYMSKSDQGMPRWPAFGALKRAMTYSFGSICFGSLLVALIDLLRQILQMIRHDVTSSGGGQIAIQILFMVFDWIIGFLKWLAEYFNHYAYSFIALYGKPYLRAAKETWYMLREKGMDALINDNLINIALGLFSMFASYMTALFTFLYLRFTSPQYNSNGAYNGALMAFSFVIALQICNIATEAIRSGTATFFVALGNDPEVFHHSYPHRFDEIFRAYPDVLRKLSHQNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPLNEKYERPPQPP -CCCCCCCCCCCCCC	15.81	23607784
17	Phosphorylation	PPQPPPAYDPNHRPP CCCCCCCCCCCCCCC	37.39	23607784
25	Phosphorylation	DPNHRPPSSSENSAA CCCCCCCCCCCCCCC	49.53	29136822
26	Phosphorylation	PNHRPPSSSENSAAA CCCCCCCCCCCCCCC	47.66	29136822
27	Phosphorylation	NHRPPSSSENSAAAN CCCCCCCCCCCCCCC	45.17	29136822
30	Phosphorylation	PPSSSENSAAANVND CCCCCCCCCCCCCCC	18.42	29136822
40	Phosphorylation	ANVNDGQTPYHFRQD CCCCCCCCCCCCCCC	31.20	23607784
42	Phosphorylation	VNDGQTPYHFRQDQY CCCCCCCCCCCCCCC	19.58	19779198
55	Ubiquitination	QYYNLNSKTSGAPIG CCCCCCCCCCCCCCC	45.71	24961812
56	Phosphorylation	YYNLNSKTSGAPIGS CCCCCCCCCCCCCCC	32.01	29688323
57	Phosphorylation	YNLNSKTSGAPIGSF CCCCCCCCCCCCCCC	36.37	29688323
63	Phosphorylation	TSGAPIGSFDEAFPT CCCCCCCCCCCCCCC	30.19	27017623
70	Phosphorylation	SFDEAFPTENDNKPR CCCCCCCCCCCCCCC	40.75	29688323
259	N-linked_Glycosylation	TYIKYDPNSSNGGCD HHHCCCCCCCCCCCC	55.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PNS1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PNS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PNS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHO2_YEAST	CHO2	genetic	20093466
THIK_YEAST	POT1	genetic	20093466
YJ24_YEAST	KCH1	genetic	20093466
CYT2_YEAST	CYT2	genetic	20093466
ENV10_YEAST	ENV10	genetic	20093466
COA4_YEAST	COA4	genetic	20093466
BUD8_YEAST	BUD8	genetic	20093466
COQ2_YEAST	COQ2	genetic	20093466
SGT2_YEAST	SGT2	genetic	20093466
NCBP2_YEAST	CBC2	genetic	20093466
MSS18_YEAST	MSS18	genetic	20093466
XYL2_YEAST	XYL2	genetic	27708008
LAM6_YEAST	YLR072W	genetic	27708008
YM79_YEAST	YMR244W	genetic	27708008
SNF1_YEAST	SNF1	genetic	27708008
GET1_YEAST	GET1	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
THIK_YEAST	POT1	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
CYT2_YEAST	CYT2	genetic	27708008
ENV10_YEAST	ENV10	genetic	27708008
BUD8_YEAST	BUD8	genetic	27708008
MSS1_YEAST	MSS1	genetic	27708008
GAS1_YEAST	GAS1	genetic	27708008
SIW14_YEAST	SIW14	genetic	27708008
LSM7_YEAST	LSM7	genetic	27708008
ATP23_YEAST	ATP23	genetic	27708008
COX10_YEAST	COX10	genetic	27708008
NCBP2_YEAST	CBC2	genetic	27708008
MSS18_YEAST	MSS18	genetic	27708008
VPS4_YEAST	VPS4	genetic	27708008
QCR2_YEAST	QCR2	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.