QCR2_YEAST - dbPTM
QCR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID QCR2_YEAST
UniProt AC P07257
Protein Name Cytochrome b-c1 complex subunit 2, mitochondrial
Gene Name QCR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 368
Subcellular Localization Mitochondrion inner membrane . Mitochondrion intermembrane space .
Protein Description Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR2 is required for the assembly of the complex..
Protein Sequence MLSAARLQFAQGSVRRLTVSARDAPTKISTLAVKVHGGSRYATKDGVAHLLNRFNFQNTNTRSALKLVRESELLGGTFKSTLDREYITLKATFLKDDLPYYVNALADVLYKTAFKPHELTESVLPAARYDYAVAEQCPVKSAEDQLYAITFRKGLGNPLLYDGVERVSLQDIKDFADKVYTKENLEVSGENVVEADLKRFVDESLLSTLPAGKSLVSKSEPKFFLGEENRVRFIGDSVAAIGIPVNKASLAQYEVLANYLTSALSELSGLISSAKLDKFTDGGLFTLFVRDQDSAVVSSNIKKIVADLKKGKDLSPAINYTKLKNAVQNESVSSPIELNFDAVKDFKLGKFNYVAVGDVSNLPYLDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
272-HydroxyisobutyrylationSARDAPTKISTLAVK
ECCCCCCEEEEEEEE		33.33-
27AcetylationSARDAPTKISTLAVK
ECCCCCCEEEEEEEE		33.3324489116
44AcetylationGGSRYATKDGVAHLL
CCCCEECHHHHHHHH		44.2924489116
79AcetylationELLGGTFKSTLDREY
HHHCCCHHHHCCCCE		42.2324489116
110PhosphorylationNALADVLYKTAFKPH
HHHHHHHHHHCCCHH		13.2227017623
115AcetylationVLYKTAFKPHELTES
HHHHHCCCHHHCCCC		42.8924489116
141PhosphorylationAEQCPVKSAEDQLYA
HHCCCCCCHHHCEEE		36.8028889911
161PhosphorylationGLGNPLLYDGVERVS
CCCCCCCCCCCEECC		20.5222369663
168PhosphorylationYDGVERVSLQDIKDF
CCCCEECCHHHHHHH		26.9122369663
173AcetylationRVSLQDIKDFADKVY
ECCHHHHHHHHHHCC		55.9024489116
1782-HydroxyisobutyrylationDIKDFADKVYTKENL
HHHHHHHHCCCCCCC		33.44-
178AcetylationDIKDFADKVYTKENL
HHHHHHHHCCCCCCC		33.4424489116
180PhosphorylationKDFADKVYTKENLEV
HHHHHHCCCCCCCEE		20.1727017623
222AcetylationLVSKSEPKFFLGEEN
CCCCCCCCEECCCCC		44.7024489116
280PhosphorylationSAKLDKFTDGGLFTL
HHCCCCCCCCCEEEE		39.2021126336
302SuccinylationAVVSSNIKKIVADLK
CEEECCHHHHHHHHH		40.4723954790
3022-HydroxyisobutyrylationAVVSSNIKKIVADLK
CEEECCHHHHHHHHH		40.47-
309SuccinylationKKIVADLKKGKDLSP
HHHHHHHHCCCCCCC		61.0923954790
315PhosphorylationLKKGKDLSPAINYTK
HHCCCCCCCCCCHHH		23.5527214570
321PhosphorylationLSPAINYTKLKNAVQ
CCCCCCHHHHHHHHC		25.9728889911
322AcetylationSPAINYTKLKNAVQN
CCCCCHHHHHHHHCC		47.2924489116
3222-HydroxyisobutyrylationSPAINYTKLKNAVQN
CCCCCHHHHHHHHCC		47.29-
334PhosphorylationVQNESVSSPIELNFD
HCCCCCCCCEEECCC		27.9527214570
344AcetylationELNFDAVKDFKLGKF
EECCCCCCCCCCCCC		60.2024489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of QCR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of QCR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of QCR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
QCR1_YEASTCOR1physical
16429126
QCR1_YEASTCOR1physical
11283351
COG2_YEASTCOG2physical
18719252
SRS2_YEASTSRS2genetic
21459050
QCR1_YEASTCOR1physical
21807901
UCRI_YEASTRIP1physical
21807901
QCR8_YEASTQCR8physical
21807901
QCR9_YEASTQCR9physical
21807901
CY1_YEASTCYT1physical
21807901
CYB_YEASTCOBphysical
21807901
QCR6_YEASTQCR6physical
21807901
QCR7_YEASTQCR7physical
21807901
UCRI_YEASTRIP1physical
24421313
GLRX3_YEASTGRX3physical
24421313
CYB_YEASTCOBphysical
24421313
COX1_YEASTCOX1physical
24421313
QCR1_YEASTCOR1physical
25683140
CYB_YEASTCOBphysical
25683140
CY1_YEASTCYT1physical
25683140
UCRI_YEASTRIP1physical
25683140
QCR6_YEASTQCR6physical
25683140
QCR7_YEASTQCR7physical
25683140
QCR8_YEASTQCR8physical
25683140
QCR9_YEASTQCR9physical
25683140
QCR10_YEASTQCR10physical
25683140
COX2_YEASTCOX2physical
25683140
BCS1_YEASTBCS1physical
25683140
DPOD2_YEASTPOL31genetic
27708008
NHP10_YEASTNHP10genetic
27708008
CYPD_YEASTCPR5genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
HDA1_YEASTHDA1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
HMI1_YEASTHMI1genetic
27708008
SEC17_YEASTSEC17genetic
27708008
IPYR_YEASTIPP1genetic
27708008
POP7_YEASTPOP7genetic
27708008
MED8_YEASTMED8genetic
27708008
RPN6_YEASTRPN6genetic
27708008
NSE4_YEASTNSE4genetic
27708008
TIM22_YEASTTIM22genetic
27708008
STN1_YEASTSTN1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CCA1_YEASTCCA1genetic
27708008
MOB2_YEASTMOB2genetic
27708008
YPT1_YEASTYPT1genetic
27708008
COPD_YEASTRET2genetic
27708008
NBP35_YEASTNBP35genetic
27708008
MCE1_YEASTCEG1genetic
27708008
SYMC_YEASTMES1genetic
27708008
MED6_YEASTMED6genetic
27708008
RRP4_YEASTRRP4genetic
27708008
ATC7_YEASTNEO1genetic
27708008
ARPC5_YEASTARC15genetic
27708008
PAN1_YEASTPAN1genetic
27708008
TIM16_YEASTPAM16genetic
27708008
RSC4_YEASTRSC4genetic
27708008
SED5_YEASTSED5genetic
27708008
RSC58_YEASTRSC58genetic
27708008
BOS1_YEASTBOS1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
GPI12_YEASTGPI12genetic
27708008
CAP_YEASTSRV2genetic
27708008
APC5_YEASTAPC5genetic
27708008
PRS10_YEASTRPT4genetic
27708008
THIL_YEASTERG10genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
CHK1_YEASTCHK1genetic
27708008
SNF5_YEASTSNF5genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RV161_YEASTRVS161genetic
27708008
KIN82_YEASTKIN82genetic
27708008
MTU1_YEASTSLM3genetic
27708008
SNF11_YEASTSNF11genetic
27708008
UBC13_YEASTUBC13genetic
27708008
PMP3_YEASTPMP3genetic
27708008
RIM15_YEASTRIM15genetic
27708008
SGF73_YEASTSGF73genetic
27708008
VAM7_YEASTVAM7genetic
27708008
AIM17_YEASTAIM17genetic
27708008
HXT8_YEASTHXT8genetic
27708008
MRX12_YEASTYJR003Cgenetic
27708008
PTK2_YEASTPTK2genetic
27708008
DAN1_YEASTDAN1genetic
27708008
RGT1_YEASTRGT1genetic
27708008
PPR1_YEASTPPR1genetic
27708008
ERG3_YEASTERG3genetic
27708008
SRN2_YEASTSRN2genetic
27708008
CPYI_YEASTTFS1genetic
27708008
ATP10_YEASTATP10genetic
27708008
DUS3_YEASTDUS3genetic
27708008
TSA1_YEASTTSA1genetic
27708008
ATP18_YEASTATP18genetic
27708008
YMP0_YEASTYMR010Wgenetic
27708008
STB4_YEASTSTB4genetic
27708008
RE114_YEASTREC114genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
ASI3_YEASTASI3genetic
27708008
VPS27_YEASTVPS27genetic
27708008
ATP23_YEASTATP23genetic
27708008
IRA2_YEASTIRA2genetic
27708008
CSK22_YEASTCKA2genetic
27708008
ECM3_YEASTECM3genetic
27708008
PDE2_YEASTPDE2genetic
27708008
SUR1_YEASTSUR1genetic
27708008
UIP4_YEASTUIP4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of QCR2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141, AND MASSSPECTROMETRY.

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