| UniProt ID | COX2_YEAST | |
|---|---|---|
| UniProt AC | P00410 | |
| Protein Name | Cytochrome c oxidase subunit 2 | |
| Gene Name | COX2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 251 | |
| Subcellular Localization |
Mitochondrion inner membrane Multi-pass membrane protein. |
|
| Protein Description | Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.. | |
| Protein Sequence | MLDLLRLQLTTFIMNDVPTPYACYFQDSATPNQEGILELHDNIMFYLLVILGLVSWMLYTIVMTYSKNPIAYKYIKHGQTIEVIWTIFPAVILLIIAFPSFILLYLCDEVISPAMTIKAIGYQWYWKYEYSDFINDSGETVEFESYVIPDELLEEGQLRLLDTDTSMVVPVDTHIRFVVTAADVIHDFAIPSLGIKVDATPGRLNQVSALIQREGVFYGACSELCGTGHANMPIKIEAVSLPKFLEWLNEQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 55 | Phosphorylation | LVILGLVSWMLYTIV HHHHHHHHHHHHHHH | 16.29 | 27017623 | |
| 59 | Phosphorylation | GLVSWMLYTIVMTYS HHHHHHHHHHHHHCC | 4.37 | 27017623 | |
| 65 | Phosphorylation | LYTIVMTYSKNPIAY HHHHHHHCCCCCCCH | 10.27 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COX2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COX2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COX2_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SCO2_YEAST | SCO2 | physical | 12125048 | |
| PT111_YEAST | PET111 | genetic | 8167413 | |
| PT111_YEAST | PET111 | genetic | 7510017 | |
| RT21_YEAST | MRP21 | genetic | 9528754 | |
| RT51_YEAST | MRP51 | genetic | 9528754 | |
| PT122_YEAST | PET122 | genetic | 9528754 | |
| RM36_YEAST | MRPL36 | genetic | 15166137 | |
| PT111_YEAST | PET111 | genetic | 15166137 | |
| RF1M_YEAST | MRF1 | genetic | 1475194 | |
| RSM28_YEAST | RSM28 | genetic | 15701796 | |
| COX1_YEAST | COX1 | physical | 22904327 | |
| COX3_YEAST | COX3 | physical | 22904327 | |
| CYB_YEAST | COB | physical | 22904327 | |
| COA6_YEAST | COA6 | physical | 26669719 | |
| COX20_YEAST | COX20 | physical | 27550809 | |
| COX1_YEAST | COX1 | physical | 24478450 | |
| COX3_YEAST | COX3 | physical | 24478450 | |
| CYB_YEAST | COB | physical | 24478450 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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