dbPTM

COX1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	COX1_YEAST
UniProt AC	P00401
Protein Name	Cytochrome c oxidase subunit 1
Gene Name	COX1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	534
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B..
Protein Sequence	MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLATIHGGSIRLATPMLYAIAFLFLFTMGGLTGVALANASLDVAFHDTYYVVGHFHYVLSMGAIFSLFAGYYYWSPQILGLNYNEKLAQIQFWLIFIGANVIFFPMHFLGINGMPRRIPDYPDAFAGWNYVASIGSFIATLSLFLFIYILYDQLVNGLNNKVNNKSVIYNKAPDFVESNTIFNLNTVKSSSIEFLLTSPPAVHSFNTPAVQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AKDIAVLYFMLAIFS HHHHHHHHHHHHHHC	4.75	30377154
25	Phosphorylation	YFMLAIFSGMAGTAM HHHHHHHCCCCHHHH	22.88	30377154
33	Phosphorylation	GMAGTAMSLIIRLEL CCCHHHHHHHHHHHH	17.60	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of COX1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of COX1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of COX1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COX3_YEAST	COX3	physical	15921494
COX6_YEAST	COX6	physical	15921494
COX5A_YEAST	COX5A	physical	15921494
COX5B_YEAST	COX5B	physical	15921494
COX2_YEAST	COX2	physical	15921494
COX4_YEAST	COX4	physical	15921494
COX7_YEAST	COX7	physical	15921494
COX8_YEAST	COX8	physical	15921494
MTF2_YEAST	MTF2	genetic	2651895
NAM7_YEAST	NAM7	genetic	2651895
NAM8_YEAST	NAM8	genetic	2651895
RF1M_YEAST	MRF1	genetic	1475194
COX10_YEAST	COX10	physical	19841065
MSS51_YEAST	MSS51	genetic	19710419
MSS51_YEAST	MSS51	physical	19710419
CYB_YEAST	COB	physical	19710419
COX3_YEAST	COX3	physical	19710419
PUT1_YEAST	PUT1	genetic	16941010
SDH3_YEAST	SDH3	genetic	16941010
PYRD_YEAST	URA1	genetic	16941010
DIC1_YEAST	DIC1	genetic	16941010
FRDS_YEAST	FRD1	genetic	16941010
FUMH_YEAST	FUM1	genetic	16941010
PROB_YEAST	PRO1	genetic	16941010
PROA_YEAST	PRO2	genetic	16941010
RMAR_YEAST	VAR1	physical	19858289
COX2_YEAST	COX2	physical	19858289
COX3_YEAST	COX3	physical	19858289
ATP6_YEAST	ATP6	physical	19858289
MRH4_YEAST	MRH4	genetic	12702275
COX2_YEAST	COX2	physical	23897805
COX3_YEAST	COX3	physical	23897805
COX2_YEAST	COX2	physical	23434581
COX3_YEAST	COX3	physical	23434581
RMAR_YEAST	VAR1	physical	23434581

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of COX1_YEAST

Related Literatures of Post-Translational Modification