RF1M_YEAST - dbPTM
RF1M_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RF1M_YEAST
UniProt AC P30775
Protein Name Peptide chain release factor 1, mitochondrial
Gene Name MRF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 413
Subcellular Localization Mitochondrion.
Protein Description Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG..
Protein Sequence MWLSKFQFPSRSIFKGVFLGHKLPLLVRLTSTTTNSKSNGSIPTQYTELSPLLVKQAEKYEAELKDLDKDLSCGIHFDVNKQKHYAKLSALTDTFIEYKEKLNELKSLQEMIVSDPSLRAEAEQEYAELVPQYETTSSRLVNKLLPPHPFADKPSLLELRPGVGGIEAMIFTQNLLDMYIGYANYRKWKYRIISKNENESGSGIIDAILSIEEAGSYDRLRFEAGVHRVQRIPSTETKGRTHTSTAAVVVLPQIGDESAKSIDAYERTFKPGEIRVDIMRASGKGGQHVNTTDSAVRLTHIPSGIVVSMQDERSQHKNKAKAFTILRARLAEKERLEKEEKERKARKSQVSSTNRSDKIRTYNFPQNRITDHRCGFTLLDLPGVLSGERLDEVIEAMSKYDSTERAKELLESN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
172PhosphorylationGIEAMIFTQNLLDMY
HHHHHHHHHHHHHHH		12.9628889911
179PhosphorylationTQNLLDMYIGYANYR
HHHHHHHHHHHHCCC		7.2928889911
182PhosphorylationLLDMYIGYANYRKWK
HHHHHHHHHCCCCEE		5.1128889911
185PhosphorylationMYIGYANYRKWKYRI
HHHHHHCCCCEEEEE		12.8528889911
287MethylationRASGKGGQHVNTTDS
ECCCCCCCCCCCCCC		46.1316321977
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RF1M_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
287QMethylation

16321977
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RF1M_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IFH1_YEASTIFH1physical
22875988
YHH7_YEASTYSC83genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
3HAO_YEASTBNA1genetic
27708008
COX7_YEASTCOX7genetic
27708008
ARF3_YEASTARF3genetic
27708008
KTR1_YEASTKTR1genetic
27708008
SYC1_YEASTSYC1genetic
27708008
FSH3_YEASTFSH3genetic
27708008
BUD7_YEASTBUD7genetic
27708008
TBP6_YEASTYTA6genetic
27708008
PNG1_YEASTPNG1genetic
27708008
SYH1_YEASTSYH1genetic
27708008
DEP1_YEASTDEP1genetic
27708008
GEM1_YEASTGEM1genetic
27708008
HIR1_YEASTHIR1genetic
27708008
QOR_YEASTZTA1genetic
27708008
AGP2_YEASTAGP2genetic
27708008
YBY9_YEASTYBR139Wgenetic
27708008
NPL4_YEASTNPL4genetic
27708008
MET8_YEASTMET8genetic
27708008
TAH1_YEASTTAH1genetic
27708008
YCZ2_YEASTYCR102Cgenetic
27708008
QRI7_YEASTQRI7genetic
27708008
HSP42_YEASTHSP42genetic
27708008
GGA1_YEASTGGA1genetic
27708008
SNX41_YEASTSNX41genetic
27708008
APA2_YEASTAPA2genetic
27708008
FCY2_YEASTFCY2genetic
27708008
DDI1_YEASTDDI1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
DCV1_YEASTDCV1genetic
27708008
PDC6_YEASTPDC6genetic
27708008
DRN1_YEASTDRN1genetic
27708008
NPR3_YEASTNPR3genetic
27708008
RRM3_YEASTRRM3genetic
27708008
GSH1_YEASTGSH1genetic
27708008
PBS2_YEASTPBS2genetic
27708008
PTK2_YEASTPTK2genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
RS27A_YEASTRPS27Agenetic
27708008
RL1D1_YEASTUTP30genetic
27708008
OAF3_YEASTOAF3genetic
27708008
PCKA_YEASTPCK1genetic
27708008
ENT4_YEASTENT4genetic
27708008
VPS13_YEASTVPS13genetic
27708008
YL012_YEASTYLR012Cgenetic
27708008
FRE8_YEASTFRE8genetic
27708008
ENV10_YEASTENV10genetic
27708008
AVL9_YEASTAVL9genetic
27708008
ELO3_YEASTELO3genetic
27708008
ERG6_YEASTERG6genetic
27708008
RAD14_YEASTRAD14genetic
27708008
AEP2_YEASTAEP2genetic
27708008
TGL3_YEASTTGL3genetic
27708008
MKS1_YEASTMKS1genetic
27708008
HMI1_YEASTHMI1genetic
27708008
EXO1_YEASTEXO1genetic
27708008
GET4_YEASTGET4genetic
27708008
AIM41_YEASTAIM41genetic
27708008
FABD_YEASTMCT1genetic
27708008
SPS4_YEASTSPS4genetic
27708008
PMT3_YEASTPMT3genetic
27708008
HPH1_YEASTFRT1genetic
27708008
SNC2_YEASTSNC2genetic
27708008
CHL1_YEASTCHL1genetic
27708008
RQC2_YEASTTAE2genetic
27708008
RAD1_YEASTRAD1genetic
27708008
SGF11_YEASTSGF11genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
UME1_YEASTUME1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
DAP1_YEASTDAP1genetic
27708008
YP199_YEASTYPL199Cgenetic
27708008
SSO1_YEASTSSO1genetic
27708008
YP260_YEASTYPL260Wgenetic
27708008
YP011_YEASTYPR011Cgenetic
27708008
VPS4_YEASTVPS4genetic
27708008
ATPA_YEASTATP1genetic
27811238
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RF1M_YEAST

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Related Literatures of Post-Translational Modification
Methylation
ReferencePubMed
"The yeast translation release factors Mrf1p and Sup45p (eRF1) aremethylated, respectively, by the methyltransferases Mtq1p and Mtq2p.";
Polevoda B., Span L., Sherman F.;
J. Biol. Chem. 281:2562-2571(2006).
Cited for: METHYLATION AT GLN-287, AND MASS SPECTROMETRY.

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