MET8_YEAST - dbPTM
MET8_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MET8_YEAST
UniProt AC P15807
Protein Name Siroheme biosynthesis protein MET8
Gene Name MET8
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 274
Subcellular Localization
Protein Description Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme..
Protein Sequence MVKSLQLAHQLKDKKILLIGGGEVGLTRLYKLIPTGCKLTLVSPDLHKSIIPKFGKFIQNEDQPDYREDAKRFINPNWDPTKNEIYEYIRSDFKDEYLDLEDENDAWYIIMTCIPDHPESARIYHLCKERFGKQQLVNVADKPDLCDFYFGANLEIGDRLQILISTNGLSPRFGALVRDEIRNLFTQMGDLALEDAVVKLGELRRGIRLLAPDDKDVKYRMDWARRCTDLFGIQHCHNIDVKRLLDLFKVMFQEQNCSLQFPPRERLLSEYCSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationGGGEVGLTRLYKLIP
CCCHHHHHHHHHHCC		16.8221126336
30PhosphorylationEVGLTRLYKLIPTGC
HHHHHHHHHHCCCCC		10.6421126336
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MET8_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MET8_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MET8_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MET8_YEASTMET8physical
18467557
FOLE_YEASTMET7genetic
21623372
CHMU_YEASTARO7genetic
21623372
KCS1_YEASTKCS1genetic
21623372
PDE2_YEASTPDE2genetic
21623372
IES5_YEASTIES5genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
RBG1_YEASTRBG1genetic
27708008
ECM15_YEASTECM15genetic
27708008
H4_YEASTHHF1genetic
27708008
SGF29_YEASTSGF29genetic
27708008
DOT1_YEASTDOT1genetic
27708008
CHAC_YEASTGCG1genetic
27708008
FMP32_YEASTFMP32genetic
27708008
MRM2_YEASTMRM2genetic
27708008
ASF1_YEASTASF1genetic
27708008
DAS1_YEASTDAS1genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
ENV10_YEASTENV10genetic
27708008
YL225_YEASTYLR225Cgenetic
27708008
EIS1_YEASTEIS1genetic
27708008
RSN1_YEASTRSN1genetic
27708008
CISY1_YEASTCIT1genetic
27708008
GLO4_YEASTGLO4genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
THP3_YEASTTHP3genetic
27708008
OPY2_YEASTOPY2genetic
27708008
THI22_YEASTTHI22genetic
27708008
SYCE1_HUMANSYCE1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MET8_YEAST

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Related Literatures of Post-Translational Modification

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