RL21B_YEAST - dbPTM
RL21B_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL21B_YEAST
UniProt AC Q12672
Protein Name 60S ribosomal protein L21-B {ECO:0000303|PubMed:9559554}
Gene Name RPL21B {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 160
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MGKSHGYRSRTRYMFQRDFRKHGAVHMSTYLKIYKVGDIVDIKANGSIQKGMPHKFYQGKTGVVYNVTKSSVGVIINKMVGNRYLEKRLNLRVEHIKHSKCRQEFLERVKANAAKRAEAKAQGVAVQLKRQPAQPRESRIVSTEGNVPQTLAPVPYETFI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationSHGYRSRTRYMFQRD
CCCHHHHCHHHHHHC		27.6521440633
21UbiquitinationMFQRDFRKHGAVHMS
HHHHCHHHCCCEEEE		46.5123749301
28PhosphorylationKHGAVHMSTYLKIYK
HCCCEEEEEEEEEEE		10.0621440633
29PhosphorylationHGAVHMSTYLKIYKV
CCCEEEEEEEEEEEE		25.8723749301
30PhosphorylationGAVHMSTYLKIYKVG
CCEEEEEEEEEEEEC		9.9323749301
32UbiquitinationVHMSTYLKIYKVGDI
EEEEEEEEEEEECCE		33.3123749301
35AcetylationSTYLKIYKVGDIVDI
EEEEEEEEECCEEEE		43.1224489116
35UbiquitinationSTYLKIYKVGDIVDI
EEEEEEEEECCEEEE		43.1223749301
35SuccinylationSTYLKIYKVGDIVDI
EEEEEEEEECCEEEE		43.1223954790
43UbiquitinationVGDIVDIKANGSIQK
ECCEEEEECCCCCCC		31.1923749301
50UbiquitinationKANGSIQKGMPHKFY
ECCCCCCCCCCCCEE		56.3522817900
55UbiquitinationIQKGMPHKFYQGKTG
CCCCCCCCEECCCCE		39.6423749301
60UbiquitinationPHKFYQGKTGVVYNV
CCCEECCCCEEEEEE		26.9523749301
61PhosphorylationHKFYQGKTGVVYNVT
CCEECCCCEEEEEEC		41.8721440633
68PhosphorylationTGVVYNVTKSSVGVI
CEEEEEECHHHHHHH		22.9022369663
69UbiquitinationGVVYNVTKSSVGVII
EEEEEECHHHHHHHH		36.1323749301
70PhosphorylationVVYNVTKSSVGVIIN
EEEEECHHHHHHHHE		22.3822369663
71PhosphorylationVYNVTKSSVGVIINK
EEEECHHHHHHHHEE		25.1720377248
78UbiquitinationSVGVIINKMVGNRYL
HHHHHHEEHHCHHHH		25.2623749301
87UbiquitinationVGNRYLEKRLNLRVE
HCHHHHHHHHCCCHH		60.6415699485
97UbiquitinationNLRVEHIKHSKCRQE
CCCHHHHCCCHHHHH		43.6722817900
100UbiquitinationVEHIKHSKCRQEFLE
HHHHCCCHHHHHHHH		32.9122817900
110UbiquitinationQEFLERVKANAAKRA
HHHHHHHHHHHHHHH		41.9922817900
115UbiquitinationRVKANAAKRAEAKAQ
HHHHHHHHHHHHHHH		50.1322817900
120UbiquitinationAAKRAEAKAQGVAVQ
HHHHHHHHHHCEEEE		32.5223749301
129UbiquitinationQGVAVQLKRQPAQPR
HCEEEEEECCCCCCC		31.7123749301
138PhosphorylationQPAQPRESRIVSTEG
CCCCCCCCCEEECCC		28.6923749301
142PhosphorylationPRESRIVSTEGNVPQ
CCCCCEEECCCCCCC		20.5422890988
143PhosphorylationRESRIVSTEGNVPQT
CCCCEEECCCCCCCC		36.7022890988
150PhosphorylationTEGNVPQTLAPVPYE
CCCCCCCCCCCCCCC		20.8622890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL21B_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL21B_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL21B_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GCN4_YEASTGCN4genetic
18423200
VPS8_YEASTVPS8genetic
20093466
YAJ9_YEASTYAR029Wgenetic
20093466
SFT2_YEASTSFT2genetic
20093466
ECM8_YEASTECM8genetic
20093466
BEM1_YEASTBEM1genetic
20093466
PAT1_YEASTPAT1genetic
20093466
RPN4_YEASTRPN4genetic
20093466
PCL6_YEASTPCL6genetic
20093466
TRPE_YEASTTRP2genetic
20093466
ASK10_YEASTASK10genetic
20093466
STB5_YEASTSTB5genetic
20093466
HAL5_YEASTHAL5genetic
20093466
RAX2_YEASTRAX2genetic
20093466
DPH5_YEASTDPH5genetic
20093466
LIPB_YEASTLIP2genetic
20093466
SYM1_YEASTSYM1genetic
20093466
FMS1_YEASTFMS1genetic
20093466
CTF18_YEASTCTF18genetic
20093466
GBLP_YEASTASC1genetic
20093466
CIN4_YEASTCIN4genetic
20093466
GAS1_YEASTGAS1genetic
20093466
WHI2_YEASTWHI2genetic
20093466
OST3_YEASTOST3genetic
20093466
SIR2_YEASTSIR2genetic
21902802
APC11_YEASTAPC11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
RPN1_YEASTRPN1genetic
27708008
RRP4_YEASTRRP4genetic
27708008
CDC12_YEASTCDC12genetic
27708008
PRS7_YEASTRPT1genetic
27708008
MED14_YEASTRGR1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
SGT1_YEASTSGT1genetic
27708008
GRPE_YEASTMGE1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
PSB5_YEASTPRE2genetic
27708008
PAT1_YEASTPAT1genetic
27708008
MAF1_YEASTMAF1genetic
27708008
RTR2_YEASTRTR2genetic
27708008
UBC13_YEASTUBC13genetic
27708008
LSM6_YEASTLSM6genetic
27708008
UBP6_YEASTUBP6genetic
27708008
VAM7_YEASTVAM7genetic
27708008
COX23_YEASTCOX23genetic
27708008
STB5_YEASTSTB5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
LSM1_YEASTLSM1genetic
27708008
HAP4_YEASTHAP4genetic
27708008
DBP7_YEASTDBP7genetic
27708008
MMM1_YEASTMMM1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
MDL2_YEASTMDL2genetic
27708008
VPS4_YEASTVPS4genetic
27708008
DOM34_YEASTDOM34genetic
29158977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL21B_YEAST

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Related Literatures of Post-Translational Modification

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