| UniProt ID | GCN4_YEAST | |
|---|---|---|
| UniProt AC | P03069 | |
| Protein Name | General control protein GCN4 | |
| Gene Name | GCN4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 281 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Is a transcription factor that is responsible for the activation of more than 30 genes required for amino acid or for purine biosynthesis in response to amino acid or purine starvation. Binds and recognize the DNA sequence: 5'-TGA[CG]TCA-3'.. | |
| Protein Sequence | MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIFDKFIKTEEDPIIKQDTPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDSTPMFEYENLEDNSKEWTSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFLPTPVLEDAKLTQTRKVKKPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVPESSDPAALKRARNTEAARRSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Phosphorylation | ALNPMGFSPLDGSKS ECCCCCCCCCCCCCC | 20.87 | 11331604 | |
| 23 | Ubiquitination | FSPLDGSKSTNENVS CCCCCCCCCCCCCCC | 67.82 | 17644757 | |
| 24 | Phosphorylation | SPLDGSKSTNENVSA CCCCCCCCCCCCCCC | 37.86 | 27017623 | |
| 32 | Phosphorylation | TNENVSASTSTAKPM CCCCCCCCHHCCCCC | 18.51 | 27017623 | |
| 34 | Phosphorylation | ENVSASTSTAKPMVG CCCCCCHHCCCCCCH | 24.71 | 27017623 | |
| 37 | Ubiquitination | SASTSTAKPMVGQLI CCCHHCCCCCCHHHH | 33.46 | 17644757 | |
| 47 | Ubiquitination | VGQLIFDKFIKTEED CHHHHHHHCCCCCCC | 37.93 | 17644757 | |
| 50 | Sumoylation | LIFDKFIKTEEDPII HHHHHCCCCCCCCCC | 53.68 | - | |
| 50 | Ubiquitination | LIFDKFIKTEEDPII HHHHHCCCCCCCCCC | 53.68 | 17644757 | |
| 58 | Sumoylation | TEEDPIIKQDTPSNL CCCCCCCCCCCCCCC | 42.72 | - | |
| 58 | Ubiquitination | TEEDPIIKQDTPSNL CCCCCCCCCCCCCCC | 42.72 | 17644757 | |
| 61 | Phosphorylation | DPIIKQDTPSNLDFD CCCCCCCCCCCCCCC | 26.56 | 11331604 | |
| 63 | Phosphorylation | IIKQDTPSNLDFDFA CCCCCCCCCCCCCEE | 52.71 | 21551504 | |
| 81 | Ubiquitination | TATAPDAKTVLPIPE CCCCCCCCCEEECCC | 46.69 | 17644757 | |
| 105 | Phosphorylation | FSSSTDSTPMFEYEN HCCCCCCCCCEEEEC | 22.91 | 11331604 | |
| 118 | Ubiquitination | ENLEDNSKEWTSLFD ECCCCCCCHHHHHCC | 64.62 | 17644757 | |
| 136 | Phosphorylation | PVTTDDVSLADKAIE CCCCCCCHHHHHHHH | 25.49 | 23810556 | |
| 140 | Ubiquitination | DDVSLADKAIESTEE CCCHHHHHHHHCCCC | 45.73 | 17644757 | |
| 165 | Phosphorylation | STTSFLPTPVLEDAK ECCCCCCCCCCCCCC | 28.33 | 10712509 | |
| 184 | Phosphorylation | RKVKKPNSVVKKSHH CCCCCCCCHHCCCCC | 36.49 | 21551504 | |
| 187 | Ubiquitination | KKPNSVVKKSHHVGK CCCCCHHCCCCCCCC | 46.53 | 15699485 | |
| 188 | Ubiquitination | KPNSVVKKSHHVGKD CCCCHHCCCCCCCCC | 43.33 | 15699485 | |
| 194 | Ubiquitination | KKSHHVGKDDESRLD CCCCCCCCCCHHHHH | 62.00 | 15699485 | |
| 211 | Ubiquitination | GVVAYNRKQRSIPLS HEEEECCCCCCCCCC | 46.56 | 17644757 | |
| 214 | Phosphorylation | AYNRKQRSIPLSPIV EECCCCCCCCCCCCC | 26.51 | 25752575 | |
| 218 | Phosphorylation | KQRSIPLSPIVPESS CCCCCCCCCCCCCCC | 13.76 | 23810556 | |
| 224 | Phosphorylation | LSPIVPESSDPAALK CCCCCCCCCCHHHHH | 33.69 | 19795423 | |
| 225 | Phosphorylation | SPIVPESSDPAALKR CCCCCCCCCHHHHHH | 46.05 | 19795423 | |
| 231 | Ubiquitination | SSDPAALKRARNTEA CCCHHHHHHHHCHHH | 39.01 | 17644757 | |
| 251 | Ubiquitination | ARKLQRMKQLEDKVE HHHHHHHHHHHHHHH | 54.65 | 17644757 | |
| 256 | Ubiquitination | RMKQLEDKVEELLSK HHHHHHHHHHHHHHC | 42.02 | 17644757 | |
| 263 | Ubiquitination | KVEELLSKNYHLENE HHHHHHHCCCCHHHH | 62.59 | 17644757 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GCN4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; THR-165 AND SER-218,AND MASS SPECTROMETRY. | |
| "Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5."; Shemer R., Meimoun A., Holtzman T., Kornitzer D.; Mol. Cell. Biol. 22:5395-5404(2002). Cited for: PHOSPHORYLATION AT THR-165. | |
