PRR1_YEAST - dbPTM
PRR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRR1_YEAST
UniProt AC P28708
Protein Name Serine/threonine-protein kinase PRR1
Gene Name PRR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 518
Subcellular Localization Cytoplasm .
Protein Description Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling..
Protein Sequence MDEYSSIYSQPKTPRLKQEGFPDSIGDQHEKALIDENGEEDKKMASTEGTTGDSRSTPLTVSIPTFENVQALPTPMTYTPLSPGNLSMSPIDQSSLNIPKRRSHARLLDDMLSVTQPNQRVVSELIAPANLSPQRVVSLPTVTEEALVNDSVDSDNYTKEPYFPESSSSTEKCDDDIFQGFLLDHWDRPLLWKKVRPIGSGNFSTVLLYELMDQSNPKLKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLENSLTRELQVLKSLNHPCIVKLLGINNPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARNGRLEAWLIQRIFTEVVLAVKYLHENSIIHRDLKLENILLKYSFDDINSFRDSPIYCKQNFIELADFGLCKKIENNEMCTARCGSEDYVSPEILMGVPYDGHLSDTWALGVILYSLFEDRLPFDPPPNASARQRSRATSHRIARFDWRWYRLSDYKTNVGKQIVENTLTRKNQRWSINEIYESPFVKTIADTLSFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDEYSSIY
-------CCCHHHHC		8.7922814378
8PhosphorylationMDEYSSIYSQPKTPR
CCCHHHHCCCCCCCC		11.8228889911
13PhosphorylationSIYSQPKTPRLKQEG
HHCCCCCCCCCCCCC		21.9628152593
123PhosphorylationQPNQRVVSELIAPAN
CCCHHHHHHHHCCCC		24.6725704821
132PhosphorylationLIAPANLSPQRVVSL
HHCCCCCCCCCEEEC		20.8517330950
138PhosphorylationLSPQRVVSLPTVTEE
CCCCCEEECCCCCHH		26.2728889911
228AcetylationQVAVKRLKYPEELSN
HHHHHHCCCHHHHCC		63.8924489116
356AcetylationSIIHRDLKLENILLK
CCCCCCCCHHHEEEC		59.0324489116
460PhosphorylationARQRSRATSHRIARF
HHHHHHHHHHCCEEC		24.7727017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ASK10_YEASTASK10physical
10688190
STE23_YEASTSTE23physical
10688190
SLX5_YEASTSLX5physical
16319894
ADD37_YEASTADD37physical
16319894
YPT32_YEASTYPT32physical
16319894
SYEC_YEASTGUS1physical
16319894
RCM1_YEASTRCM1physical
16319894
NCL1_YEASTNCL1physical
16319894
SYSC_YEASTSES1physical
16319894
TRM13_YEASTTRM13physical
16319894
YMD7_YEASTYML037Cphysical
16319894
VCX1_YEASTVCX1physical
16319894
YP013_YEASTCMR3physical
16319894
BRE2_YEASTBRE2physical
16319894
KU70_YEASTYKU70physical
16319894
RL6A_YEASTRPL6Aphysical
16319894
FAR3_YEASTFAR3physical
16319894
SEC2_YEASTSEC2physical
16319894
YL257_YEASTYLR257Wphysical
16319894
GPT1_YEASTSCT1physical
16319894
DIG2_YEASTDIG2physical
16319894
PRR1_YEASTPRR1physical
16319894
FZO1_YEASTFZO1physical
16319894
ADH1_YEASTADH1physical
16319894
AVT1_YEASTAVT1physical
16319894
ISR1_YEASTISR1genetic
19269370
SSZ1_YEASTSSZ1physical
19536198
CHS3_YEASTCHS3genetic
20093466
YBQ6_YEASTYBR056Wgenetic
20093466
CSM1_YEASTCSM1genetic
20093466
XRS2_YEASTXRS2genetic
20093466
CHS7_YEASTCHS7genetic
20093466
DPOD3_YEASTPOL32genetic
20093466
CHS5_YEASTCHS5genetic
20093466
YMD8_YEASTYMD8genetic
20093466
EOS1_YEASTEOS1genetic
20093466
VPH1_YEASTVPH1genetic
20093466
AIM44_YEASTAIM44genetic
20093466
GFA1_YEASTGFA1physical
20489023
CTF4_YEASTCTF4physical
21460040
RL4A_YEASTRPL4Aphysical
21460040
YCQ6_YEASTYCR016Wphysical
21460040
PP2C1_YEASTPTC1genetic
21127252
AFT1_YEASTAFT1genetic
21127252
BUB1_YEASTBUB1genetic
21127252
BCK1_YEASTBCK1genetic
21127252
TOM40_YEASTTOM40physical
21215441
YF21A_YEASTYGR161W-Agenetic
22282571
YG22A_YEASTYGR161W-Agenetic
22282571
BST1_YEASTBST1genetic
22282571
YBQ6_YEASTYBR056Wgenetic
22282571
VPH1_YEASTVPH1genetic
22282571
CHS3_YEASTCHS3genetic
22282571
CSM1_YEASTCSM1genetic
22282571
XRS2_YEASTXRS2genetic
22282571
DPOD3_YEASTPOL32genetic
22282571
CHS7_YEASTCHS7genetic
22282571
EOS1_YEASTEOS1genetic
22282571
YMD8_YEASTYMD8genetic
22282571
AIM44_YEASTAIM44genetic
22282571
CHS3_YEASTCHS3genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
CSM1_YEASTCSM1genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
UME6_YEASTUME6genetic
27708008
XRS2_YEASTXRS2genetic
27708008
NPY1_YEASTNPY1genetic
27708008
RPA34_YEASTRPA34genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
TR732_YEASTTRM732genetic
27708008
EOS1_YEASTEOS1genetic
27708008
CKS1_YEASTCKS1genetic
29674565
LCB2_YEASTLCB2genetic
29674565
CDC1_YEASTCDC1genetic
29674565
BCK1_YEASTBCK1genetic
29674565
MED4_YEASTMED4genetic
29674565
MYO2_YEASTMYO2genetic
29674565
PEF1_YEASTPEF1genetic
29674565
SFL1_YEASTSFL1genetic
29674565
CSG2_YEASTCSG2genetic
29674565
THRC_YEASTTHR4genetic
29674565
BRE1_YEASTBRE1genetic
29674565
NBP2_YEASTNBP2genetic
29674565
CEM1_YEASTCEM1genetic
29674565
STB5_YEASTSTB5genetic
29674565
PBS2_YEASTPBS2genetic
29674565
SUB1_YEASTSUB1genetic
29674565
SCS7_YEASTSCS7genetic
29674565
GAS1_YEASTGAS1genetic
29674565
OST2_YEASTOST2genetic
29674565
SUR1_YEASTSUR1genetic
29674565
GPI2_YEASTGPI2genetic
29674565
KPC1_YEASTPKC1genetic
29674565
SWI5_YEASTSWI5genetic
29674565
LSM6_YEASTLSM6genetic
29674565
SWI4_YEASTSWI4genetic
29674565
BEM2_YEASTBEM2genetic
29674565
GUP1_YEASTGUP1genetic
29674565
NBP35_YEASTNBP35genetic
29674565
DAM1_YEASTDAM1genetic
29674565
AZR1_YEASTAZR1genetic
29674565
RPA34_YEASTRPA34genetic
29674565
CSF1_YEASTCSF1genetic
29674565
NMT_YEASTNMT1genetic
29674565
SC61A_YEASTSEC61genetic
29674565
LSM7_YEASTLSM7genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.

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