RL6A_YEAST - dbPTM
RL6A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL6A_YEAST
UniProt AC Q02326
Protein Name 60S ribosomal protein L6-A {ECO:0000303|PubMed:9559554}
Gene Name RPL6A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 176
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MSAQKAPKWYPSEDVAALKKTRKAARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHLEDNTLLISGPFKVNGVPLRRVNARYVIATSTKVSVEGVNVEKFNVEYFAKEKLTKKEKKEANLFPEQQNKEIKAERVEDQKVVDKALIAEIKKTPLLKQYLSASFSLKNGDKPHMLKF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSAQKAPKW
------CCCCCCCCC		39.1310601260
5Ubiquitination---MSAQKAPKWYPS
---CCCCCCCCCCCH		67.3922817900
8UbiquitinationMSAQKAPKWYPSEDV
CCCCCCCCCCCHHHH		65.3123749301
8AcetylationMSAQKAPKWYPSEDV
CCCCCCCCCCCHHHH		65.3124489116
10PhosphorylationAQKAPKWYPSEDVAA
CCCCCCCCCHHHHHH		11.7325521595
12PhosphorylationKAPKWYPSEDVAALK
CCCCCCCHHHHHHHH		30.6322369663
19UbiquitinationSEDVAALKKTRKAAR
HHHHHHHHHHHHHHC		47.5823749301
19AcetylationSEDVAALKKTRKAAR
HHHHHHHHHHHHHHC		47.5824489116
20UbiquitinationEDVAALKKTRKAARP
HHHHHHHHHHHHHCC		55.1815699485
29UbiquitinationRKAARPQKLRASLVP
HHHHCCHHHHHHCCC		42.4923749301
29AcetylationRKAARPQKLRASLVP
HHHHCCHHHHHHCCC		42.4924489116
33PhosphorylationRPQKLRASLVPGTVL
CCHHHHHHCCCCCHH		24.3822369663
38PhosphorylationRASLVPGTVLILLAG
HHHCCCCCHHEEEEE		13.1822369663
56UbiquitinationGKRVVYLKHLEDNTL
CCEEEEEEECCCCEE		28.5817644757
66PhosphorylationEDNTLLISGPFKVNG
CCCEEEEECCEEECC		40.1428889911
70UbiquitinationLLISGPFKVNGVPLR
EEEECCEEECCEECC		37.6117644757
70AcetylationLLISGPFKVNGVPLR
EEEECCEEECCEECC		37.6124489116
90UbiquitinationYVIATSTKVSVEGVN
EEEEECEEEEEECCC		32.0723749301
92PhosphorylationIATSTKVSVEGVNVE
EEECEEEEEECCCHH		18.9230377154
100UbiquitinationVEGVNVEKFNVEYFA
EECCCHHHEEHHHHH		37.6523749301
108UbiquitinationFNVEYFAKEKLTKKE
EEHHHHHHHHCCHHH		45.5423749301
110UbiquitinationVEYFAKEKLTKKEKK
HHHHHHHHCCHHHHH		61.8322817900
113UbiquitinationFAKEKLTKKEKKEAN
HHHHHCCHHHHHHHC		70.1722817900
114UbiquitinationAKEKLTKKEKKEANL
HHHHCCHHHHHHHCC		70.3222817900
116UbiquitinationEKLTKKEKKEANLFP
HHCCHHHHHHHCCCH		65.8722817900
117UbiquitinationKLTKKEKKEANLFPE
HCCHHHHHHHCCCHH		64.2523749301
128AcetylationLFPEQQNKEIKAERV
CCHHHHHHHHHHHHH		57.3824489116
128UbiquitinationLFPEQQNKEIKAERV
CCHHHHHHHHHHHHH		57.3823749301
131UbiquitinationEQQNKEIKAERVEDQ
HHHHHHHHHHHHCCH		45.3322817900
131AcetylationEQQNKEIKAERVEDQ
HHHHHHHHHHHHCCH		45.3324489116
139UbiquitinationAERVEDQKVVDKALI
HHHHCCHHHHCHHHH		57.4523749301
143UbiquitinationEDQKVVDKALIAEIK
CCHHHHCHHHHHHHH		33.2222817900
150UbiquitinationKALIAEIKKTPLLKQ
HHHHHHHHCCHHHHH		41.9415699485
151UbiquitinationALIAEIKKTPLLKQY
HHHHHHHCCHHHHHH		62.1222817900
156UbiquitinationIKKTPLLKQYLSASF
HHCCHHHHHHHHHHE		44.5823749301
160PhosphorylationPLLKQYLSASFSLKN
HHHHHHHHHHEECCC		19.5522369663
162PhosphorylationLKQYLSASFSLKNGD
HHHHHHHHEECCCCC		16.4022369663
164PhosphorylationQYLSASFSLKNGDKP
HHHHHHEECCCCCCC		35.6222369663
166UbiquitinationLSASFSLKNGDKPHM
HHHHEECCCCCCCCC		58.6522817900
170UbiquitinationFSLKNGDKPHMLKF-
EECCCCCCCCCCCC-		37.9223749301
175UbiquitinationGDKPHMLKF------
CCCCCCCCC------		41.2623749301
175AcetylationGDKPHMLKF------
CCCCCCCCC------		41.2624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL6A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL6A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL6A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCM62_YEASTTCM62genetic
20093466
BUD31_YEASTBUD31genetic
20093466
PAT1_YEASTPAT1genetic
20093466
YCY0_YEASTYCR090Cgenetic
20093466
RPN4_YEASTRPN4genetic
20093466
VPS41_YEASTVPS41genetic
20093466
NUM1_YEASTNUM1genetic
20093466
HMO1_YEASTHMO1genetic
20093466
EAF1_YEASTEAF1genetic
20093466
UBP6_YEASTUBP6genetic
20093466
YG35_YEASTYGR125Wgenetic
20093466
DGR2_YEASTDGR2genetic
20093466
DYHC_YEASTDYN1genetic
20093466
PTR2_YEASTPTR2genetic
20093466
MMM1_YEASTMMM1genetic
20093466
SRR1L_YEASTBER1genetic
20093466
RL6B_YEASTRPL6Bgenetic
20093466
RL6B_YEASTRPL6Bgenetic
22377630
MAK5_YEASTMAK5genetic
27708008
GNA1_YEASTGNA1genetic
27708008
YPT1_YEASTYPT1genetic
27708008
SSL1_YEASTSSL1genetic
27708008
NSE1_YEASTNSE1genetic
27708008
MED14_YEASTRGR1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
NMT_YEASTNMT1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
CD123_YEASTCDC123genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TCM62_YEASTTCM62genetic
27708008
BUD31_YEASTBUD31genetic
27708008
CDC24_YEASTCDC24genetic
27708008
MPS1_YEASTMPS1genetic
27708008
PRP11_YEASTPRP11genetic
27708008
RPN6_YEASTRPN6genetic
27708008
RRP42_YEASTRRP42genetic
27708008
SLU7_YEASTSLU7genetic
27708008
MSS4_YEASTMSS4genetic
27708008
SNU56_YEASTSNU56genetic
27708008
GPI8_YEASTGPI8genetic
27708008
UTP5_YEASTUTP5genetic
27708008
RMRP_YEASTSNM1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
GDI1_YEASTGDI1genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN11_YEASTRPN11genetic
27708008
SAD1_YEASTSAD1genetic
27708008
PSB7_YEASTPRE4genetic
27708008
RPN12_YEASTRPN12genetic
27708008
PSA1_YEASTSCL1genetic
27708008
RNA15_YEASTRNA15genetic
27708008
PRS8_YEASTRPT6genetic
27708008
ALG2_YEASTALG2genetic
27708008
COPB2_YEASTSEC27genetic
27708008
TIP20_YEASTTIP20genetic
27708008
SMD1_YEASTSMD1genetic
27708008
DAM1_YEASTDAM1genetic
27708008
RPN1_YEASTRPN1genetic
27708008
SAM35_YEASTSAM35genetic
27708008
CDC23_YEASTCDC23genetic
27708008
SPC97_YEASTSPC97genetic
27708008
PAN1_YEASTPAN1genetic
27708008
GRP78_YEASTKAR2genetic
27708008
EXO70_YEASTEXO70genetic
27708008
KRE9_YEASTKRE9genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
ESS1_YEASTESS1genetic
27708008
FIP1_YEASTFIP1genetic
27708008
RPF2_YEASTRPF2genetic
27708008
SPC24_YEASTSPC24genetic
27708008
RRP5_YEASTRRP5genetic
27708008
RNA1_YEASTRNA1genetic
27708008
RNT1_YEASTRNT1genetic
27708008
CUS1_YEASTCUS1genetic
27708008
RLP7_YEASTRLP7genetic
27708008
LST8_YEASTLST8genetic
27708008
NOP2_YEASTNOP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
ARPC2_YEASTARC35genetic
27708008
PROF_YEASTPFY1genetic
27708008
SMP3_YEASTSMP3genetic
27708008
GRPE_YEASTMGE1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
PSA7_YEASTPRE10genetic
27708008
TIM50_YEASTTIM50genetic
27708008
IPL1_YEASTIPL1genetic
27708008
TF2B_YEASTSUA7genetic
27708008
RPN7_YEASTRPN7genetic
27708008
IWS1_YEASTSPN1genetic
27708008
ORC4_YEASTORC4genetic
27708008
PRP4_YEASTPRP4genetic
27708008
PAT1_YEASTPAT1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
VPS41_YEASTVPS41genetic
27708008
NUM1_YEASTNUM1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
UBP6_YEASTUBP6genetic
27708008
LSM1_YEASTLSM1genetic
27708008
DGR2_YEASTDGR2genetic
27708008
DYHC_YEASTDYN1genetic
27708008
PTR2_YEASTPTR2genetic
27708008
SRR1L_YEASTBER1genetic
27708008
GBLP_YEASTASC1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL6A_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"The action of N-terminal acetyltransferases on yeast ribosomalproteins.";
Arnold R.J., Polevoda B., Reilly J.P., Sherman F.;
J. Biol. Chem. 274:37035-37040(1999).
Cited for: CLEAVAGE OF INITIATOR METHIONINE, AND ACETYLATION AT SER-2 BY NATA.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-162, AND MASSSPECTROMETRY.

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