DGR2_YEAST - dbPTM
DGR2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DGR2_YEAST
UniProt AC P32330
Protein Name 2-deoxy-glucose resistant protein 2
Gene Name DGR2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 852
Subcellular Localization
Protein Description
Protein Sequence MFKSKTSTLSYDETPNSNEGDRNATPVNPKEKSQTKHLNIPGDRSRHSSIADSKRSSSRYDGGYSADIIPAQLRFIDNIDYGTRLRKTLHRNSVVSNGYNKLSENDRWYFDLFDRKYFENYLEEPTYIKIFKKKEGLEQFDRMFLAQELKIPDVYKSTTYQGEPAVANSELFKNSICCCTFSHDGKYMVIGCKDGSLHLWKVINSPVKRSEMGRSEKSVSASRANSLKIQRHLASISSHNGSISSNDLKPSDQFEGPSKQLHLYAPVFYSDVFRVFMEHALDILDANWSKNGFLITASMDKTAKLWHPERKYSLKTFVHPDFVTSAIFFPNDDRFIITGCLDHRCRLWSILDNEVSYAFDCKDLITSLTLSPPGGEYTIIGTFNGYIYVLLTHGLKFVSSFHVSDKSTQGTTKNSFHPSSEYGKVQHGPRITGLQCFFSKVDKNLRLIVTTNDSKIQIFDLNEKKPLELFKGFQSGSSRHRGQFLMMKNEPVVFTGSDDHWFYTWKMQSFNLSAEMNCTAPHRKKRLSGSMSLKGLLRIVSNKSTNDECLTETSNQSSSHTFTNSSKNVLQTQTVGSQAIKNNHYISFHAHNSPVTCASIAPDVAIKNLSLSNDLIFELTSQYFKEMGQNYSESKETCDNKPNHPVTETGGFSSNLSNVVNNVGTILITTDSQGLIRVFRTDILPEIRKKIIEKFHEYNLFHLEAAGKINNHNNDSILENRMDERSSTEDNEFSTTPPSNTHNSRPSHDFCELHPNNSPVISGMPSRASAIFKNSIFNKSNGSFISLKSRSESTSSTVFGPHDIPRVSTTYPKLKCDVCNGSNFECASKNPIAGGDSGFTCADCGTILNNFR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MFKSKTSTLSYDE
--CCCCCCCCCCCCC		33.7522369663
7Phosphorylation-MFKSKTSTLSYDET
-CCCCCCCCCCCCCC		30.9622369663
8PhosphorylationMFKSKTSTLSYDETP
CCCCCCCCCCCCCCC		25.5922369663
10PhosphorylationKSKTSTLSYDETPNS
CCCCCCCCCCCCCCC		30.5422369663
11PhosphorylationSKTSTLSYDETPNSN
CCCCCCCCCCCCCCC		22.4022369663
14PhosphorylationSTLSYDETPNSNEGD
CCCCCCCCCCCCCCC		25.5227214570
17PhosphorylationSYDETPNSNEGDRNA
CCCCCCCCCCCCCCC		37.1522369663
25PhosphorylationNEGDRNATPVNPKEK
CCCCCCCCCCCHHHH		31.1722369663
45PhosphorylationLNIPGDRSRHSSIAD
CCCCCCCCCCCHHCC		38.8024961812
48PhosphorylationPGDRSRHSSIADSKR
CCCCCCCCHHCCCCC		23.4824961812
49PhosphorylationGDRSRHSSIADSKRS
CCCCCCCHHCCCCCC		18.7024961812
53PhosphorylationRHSSIADSKRSSSRY
CCCHHCCCCCCCCCC		22.4324961812
56PhosphorylationSIADSKRSSSRYDGG
HHCCCCCCCCCCCCC		36.0823749301
57PhosphorylationIADSKRSSSRYDGGY
HCCCCCCCCCCCCCC		23.9122369663
58PhosphorylationADSKRSSSRYDGGYS
CCCCCCCCCCCCCCC		35.7922369663
60PhosphorylationSKRSSSRYDGGYSAD
CCCCCCCCCCCCCCC		22.3822369663
64PhosphorylationSSRYDGGYSADIIPA
CCCCCCCCCCCCCCH		13.2523749301
65PhosphorylationSRYDGGYSADIIPAQ
CCCCCCCCCCCCCHH		23.8022369663
88PhosphorylationYGTRLRKTLHRNSVV
HHHHHHHHHCCCCCC		22.7419823750
93PhosphorylationRKTLHRNSVVSNGYN
HHHHCCCCCCCCCCC		24.6921440633
96PhosphorylationLHRNSVVSNGYNKLS
HCCCCCCCCCCCCCC		23.5222369663
99PhosphorylationNSVVSNGYNKLSEND
CCCCCCCCCCCCCCC		17.2421440633
121PhosphorylationDRKYFENYLEEPTYI
CHHHHHHHHCCCCEE		14.3221440633
126PhosphorylationENYLEEPTYIKIFKK
HHHHCCCCEEEEEEC		40.9521440633
127PhosphorylationNYLEEPTYIKIFKKK
HHHCCCCEEEEEECH		15.7821440633
218PhosphorylationEMGRSEKSVSASRAN
HCCCCCCCCCHHHHH		19.7722369663
220PhosphorylationGRSEKSVSASRANSL
CCCCCCCCHHHHHHH		27.8422369663
222PhosphorylationSEKSVSASRANSLKI
CCCCCCHHHHHHHHH		25.1522369663
226PhosphorylationVSASRANSLKIQRHL
CCHHHHHHHHHHHHH		30.0122369663
235PhosphorylationKIQRHLASISSHNGS
HHHHHHHHHHCCCCC		29.3924961812
237PhosphorylationQRHLASISSHNGSIS
HHHHHHHHCCCCCCC		24.0524961812
238PhosphorylationRHLASISSHNGSISS
HHHHHHHCCCCCCCC		21.2119779198
242PhosphorylationSISSHNGSISSNDLK
HHHCCCCCCCCCCCC		25.3119779198
244PhosphorylationSSHNGSISSNDLKPS
HCCCCCCCCCCCCCH		25.4521440633
245PhosphorylationSHNGSISSNDLKPSD
CCCCCCCCCCCCCHH		32.4721440633
450PhosphorylationKNLRLIVTTNDSKIQ
CCEEEEEECCCCCEE		16.9419823750
451PhosphorylationNLRLIVTTNDSKIQI
CEEEEEECCCCCEEE		26.5719823750
454PhosphorylationLIVTTNDSKIQIFDL
EEEECCCCCEEEEEC		33.4619823750
528PhosphorylationPHRKKRLSGSMSLKG
CCCCCCCCCCCCHHH		32.6222369663
530PhosphorylationRKKRLSGSMSLKGLL
CCCCCCCCCCHHHHH		11.2122369663
532PhosphorylationKRLSGSMSLKGLLRI
CCCCCCCCHHHHHHH		28.7321440633
534AcetylationLSGSMSLKGLLRIVS
CCCCCCHHHHHHHHC		39.9624489116
541PhosphorylationKGLLRIVSNKSTNDE
HHHHHHHCCCCCCCC		35.8523749301
544PhosphorylationLRIVSNKSTNDECLT
HHHHCCCCCCCCCCC		36.3723749301
557PhosphorylationLTETSNQSSSHTFTN
CCCCCCCCCCCEECC		37.7523749301
574PhosphorylationKNVLQTQTVGSQAIK
CCEEEEEEECCHHHH		30.1619779198
577PhosphorylationLQTQTVGSQAIKNNH
EEEEEECCHHHHCCC		16.4719779198
716PhosphorylationINNHNNDSILENRMD
CCCCCCHHHHHHCCC		31.0622369663
726PhosphorylationENRMDERSSTEDNEF
HHCCCCCCCCCCCCC		39.2928889911
734PhosphorylationSTEDNEFSTTPPSNT
CCCCCCCCCCCCCCC		25.7830377154
736PhosphorylationEDNEFSTTPPSNTHN
CCCCCCCCCCCCCCC		31.8128889911
775PhosphorylationASAIFKNSIFNKSNG
HHHHHHCCCEECCCC		29.1919779198
780PhosphorylationKNSIFNKSNGSFISL
HCCCEECCCCCEEEE		47.7522369663
783PhosphorylationIFNKSNGSFISLKSR
CEECCCCCEEEEEEC		24.5322369663
786PhosphorylationKSNGSFISLKSRSES
CCCCCEEEEEECCCC		27.9522369663
789PhosphorylationGSFISLKSRSESTSS
CCEEEEEECCCCCCC		46.4621440633
791PhosphorylationFISLKSRSESTSSTV
EEEEEECCCCCCCCE		42.8822369663
793PhosphorylationSLKSRSESTSSTVFG
EEEECCCCCCCCEEC		34.5322369663
794PhosphorylationLKSRSESTSSTVFGP
EEECCCCCCCCEECC		23.7322369663
795PhosphorylationKSRSESTSSTVFGPH
EECCCCCCCCEECCC		33.0421440633
796PhosphorylationSRSESTSSTVFGPHD
ECCCCCCCCEECCCC		28.7822369663
797PhosphorylationRSESTSSTVFGPHDI
CCCCCCCCEECCCCC		21.4421440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DGR2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DGR2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DGR2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AIM3_YEASTAIM3genetic
21035341
ELO2_YEASTELO2genetic
27708008
LSM6_YEASTLSM6genetic
27708008
ASK10_YEASTASK10genetic
27708008
NGL2_YEASTNGL2genetic
27708008
LTE1_YEASTLTE1genetic
27708008
YBF9_YEASTYBL059Wgenetic
27708008
NU170_YEASTNUP170genetic
27708008
GAL10_YEASTGAL10genetic
27708008
RKM3_YEASTRKM3genetic
27708008
ECM33_YEASTECM33genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
MGR1_YEASTMGR1genetic
27708008
MRC1_YEASTMRC1genetic
27708008
RV161_YEASTRVS161genetic
27708008
FUB1_YEASTFUB1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
RXT3_YEASTRXT3genetic
27708008
HBT1_YEASTHBT1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
SWM1_YEASTSWM1genetic
27708008
GGA1_YEASTGGA1genetic
27708008
XRS2_YEASTXRS2genetic
27708008
RV167_YEASTRVS167genetic
27708008
GNP1_YEASTGNP1genetic
27708008
AIM11_YEASTAIM11genetic
27708008
BEM2_YEASTBEM2genetic
27708008
AAKG_YEASTSNF4genetic
27708008
MRM2_YEASTMRM2genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
DBF2_YEASTDBF2genetic
27708008
AIM17_YEASTAIM17genetic
27708008
NPR3_YEASTNPR3genetic
27708008
GOSR1_YEASTGOS1genetic
27708008
PTH_YEASTPTH1genetic
27708008
TED1_YEASTTED1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
MDV1_YEASTMDV1genetic
27708008
RAV1_YEASTRAV1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
ILM1_YEASTILM1genetic
27708008
YJ90_YEASTYJR120Wgenetic
27708008
MIC60_YEASTMIC60genetic
27708008
PAM17_YEASTPAM17genetic
27708008
BRE2_YEASTBRE2genetic
27708008
SIC1_YEASTSIC1genetic
27708008
CSF1_YEASTCSF1genetic
27708008
TO6BL_YEASTREC102genetic
27708008
VPS9_YEASTVPS9genetic
27708008
MGR3_YEASTMGR3genetic
27708008
MRE11_YEASTMRE11genetic
27708008
ADE_YEASTAAH1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
MDHC_YEASTMDH2genetic
27708008
BUB3_YEASTBUB3genetic
27708008
DIA2_YEASTDIA2genetic
27708008
FABD_YEASTMCT1genetic
27708008
TPO4_YEASTTPO4genetic
27708008
SNC2_YEASTSNC2genetic
27708008
MNE1_YEASTMNE1genetic
27708008
LEE1_YEASTLEE1genetic
27708008
HUT1_YEASTHUT1genetic
27708008
CG12_YEASTCLN2genetic
27708008
YMZ2_YEASTYMR102Cgenetic
28774891
YPK1_YEASTYPK1genetic
28774891
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DGR2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-96, AND MASSSPECTROMETRY.

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