dbPTM

TO6BL_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TO6BL_YEAST
UniProt AC	Q02721
Protein Name	Meiotic recombination protein REC102
Gene Name	REC102 {ECO:0000303\|PubMed:2060778}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	264
Subcellular Localization	Nucleus . Associates with chromatin during prophase. Recruitment to chromatin depends on REC104, SPO11 and SKI8.
Protein Description	Required for formation of the SPO11-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May mediate the interaction between SPO11 subunits during meiosis. Also needed for homolog chromosome pairing, synaptonemal complex formation, and for the proper timing of the first meiotic division. Not required for mitosis and mitotic DNA repair mechanisms..
Protein Sequence	MARDITFLTVFLESCGAVNNDEAGKLLSAWTSTVRIEGPESTDSNSLYIPLLPPGMLKIKLNFKMNDRLVTEEQELFTKLREIVGSSIRFWEEQLFYQVQDVSTIENHVILSLKCTILTDAQISTFISKPRELHTHAKGYPEIYYLSELSTTVNFFSKEGNYVEISQVIPHFNEYFSSLIVSQLEFEYPMVFSMISRLRLKWQQSSLAPISYALTSNSVLLPIMLNMIAQDKSSTTAYQILCRRRGPPIQNFQIFSLPAVTYNK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
42	Phosphorylation	RIEGPESTDSNSLYI EEECCCCCCCCCEEE	27017623
44	Phosphorylation	EGPESTDSNSLYIPL ECCCCCCCCCEEEEE	27017623
46	Phosphorylation	PESTDSNSLYIPLLP CCCCCCCCEEEEECC	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TO6BL_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TO6BL_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TO6BL_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPO11_YEAST	SPO11	physical	12897161
SPO11_YEAST	SPO11	physical	11805049
RE104_YEAST	REC104	physical	15044957
SPO11_YEAST	SPO11	genetic	12897161
SPO13_YEAST	SPO13	genetic	1732169
RED1_YEAST	RED1	genetic	17314980
XRN1_YEAST	XRN1	genetic	17314980
SAC3_YEAST	SAC3	genetic	17314980
SPO11_YEAST	SPO11	genetic	11805049
ERV15_YEAST	ERV15	genetic	20093466
RLA1_YEAST	RPP1A	genetic	20093466
NHP10_YEAST	NHP10	genetic	20093466
PMP3_YEAST	PMP3	genetic	20093466
GET2_YEAST	GET2	genetic	20093466
GET1_YEAST	GET1	genetic	20093466
SAC1_YEAST	SAC1	genetic	20093466
DCOR_YEAST	SPE1	genetic	20093466
SMA2_YEAST	SMA2	genetic	20093466
INO4_YEAST	INO4	genetic	20093466
ERV15_YEAST	ERV15	genetic	27708008
NHP10_YEAST	NHP10	genetic	27708008
RLA1_YEAST	RPP1A	genetic	27708008
UBX2_YEAST	UBX2	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
GET2_YEAST	GET2	genetic	29674565
VPS13_YEAST	VPS13	genetic	29674565
RUD3_YEAST	RUD3	genetic	29674565
DPOD_YEAST	POL3	genetic	29674565
TCPZ_YEAST	CCT6	genetic	29674565
PPN1_YEAST	PPN1	genetic	29674565
KRE28_YEAST	KRE28	genetic	29674565
CHO2_YEAST	CHO2	genetic	29674565
VPS51_YEAST	VPS51	genetic	29674565
COG3_YEAST	COG3	genetic	29674565
GET1_YEAST	GET1	genetic	29674565
PSA3_YEAST	PRE9	genetic	29674565
APQ12_YEAST	APQ12	genetic	29674565
IST3_YEAST	IST3	genetic	29674565
TGS1_YEAST	TGS1	genetic	29674565

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TO6BL_YEAST

Related Literatures of Post-Translational Modification