dbPTM

SPO13_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPO13_YEAST
UniProt AC	P23624
Protein Name	Meiosis-specific protein SPO13
Gene Name	SPO13
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	291
Subcellular Localization	Nucleus .
Protein Description	Required for meiosis I segmentation. [PubMed: 2123556 Probably acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage]
Protein Sequence	MAPRKRFRLLELGSPTHSKRKVQKPLQEKTPNLRVSPLAFKIGKEIKNKEIRKTKKTESENIFNSKHVDLRLESPHPGLNFVSDAQQYSKAGDVRYLKNKSSNTLKNERQTIERPSFDNSLRFEDIEQPPKSTSTPVLSQSSQINVEREAPMFPVPYYIAPSPMYNFSPYQNFVGNPTFLTPSHNPNLNYAIPIQRPELLYPNVNVYDSPLFKKTRLPHQTKSLDKEKNYQYLPIYPVSISNNGDFVGQETPRAAPKLSKKRLSNTLDVNCSDYESSGQNATYNDSESSLN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	FRLLELGSPTHSKRK EEEECCCCCCCCCCC	38.97	27214570
16	Phosphorylation	LLELGSPTHSKRKVQ EECCCCCCCCCCCCC	40.24	27214570
36	Phosphorylation	KTPNLRVSPLAFKIG CCCCCCCCHHHHHHC	14.04	27214570
74	Phosphorylation	HVDLRLESPHPGLNF CCEEEECCCCCCCCC	32.85	27214570
133	Phosphorylation	IEQPPKSTSTPVLSQ CCCCCCCCCCCCCCC	42.62	27214570
135	Phosphorylation	QPPKSTSTPVLSQSS CCCCCCCCCCCCCCC	19.94	27214570
221	Phosphorylation	KTRLPHQTKSLDKEK HCCCCCCCCCCCCCC	21.40	21126336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	CDC20	P26309	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPO13_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPO13_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IDH2_YEAST	IDH2	physical	11805837
IF4A_YEAST	TIF2	physical	11805837
ADY1_YEAST	PFS1	physical	10688190
CBF3A_YEAST	CBF2	physical	15620644
BUD3_YEAST	BUD3	genetic	10511544
DMC1_YEAST	DMC1	genetic	10511544
ELOA1_YEAST	ELA1	genetic	10511544
INP52_YEAST	INP52	genetic	10511544
MSC1_YEAST	MSC1	genetic	10511544
MSC2_YEAST	MSC2	genetic	10511544
MSC3_YEAST	MSC3	genetic	10511544
PT122_YEAST	PET122	genetic	10511544
UBR1_YEAST	UBR1	genetic	10511544
RME1_YEAST	RME1	genetic	3285137
SIR2_YEAST	SIR2	genetic	3285137
SLK19_YEAST	SLK19	genetic	11050386
RAD50_YEAST	RAD50	genetic	8529274
SPO11_YEAST	SPO11	genetic	2060778
MEI4_YEAST	MEI4	genetic	2060778
MER1_YEAST	MER1	genetic	2060778
TO6BL_YEAST	REC102	genetic	2060778
RE104_YEAST	REC104	genetic	2060778
RE107_YEAST	REC107	genetic	2060778
TO6BL_YEAST	REC102	genetic	1545806
RE107_YEAST	REC107	genetic	1545806
AMA1_YEAST	AMA1	genetic	15620645
RAD50_YEAST	RAD50	genetic	1840632
SPO11_YEAST	SPO11	genetic	7045878
MRE11_YEAST	MRE11	genetic	8417989
NAM8_YEAST	NAM8	genetic	8417989
RE114_YEAST	REC114	genetic	8417989
MEK1_YEAST	MEK1	genetic	8417989
CDC5_YEAST	CDC5	physical	19013276
MAD2_YEAST	MAD2	genetic	12101124
ESP1_YEAST	ESP1	genetic	20407133
SPO11_YEAST	SPO11	genetic	21515575
PCH2_YEAST	PCH2	genetic	21515575
SWC4_YEAST	SWC4	genetic	27708008
DED1_YEAST	DED1	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
UAP1_YEAST	QRI1	genetic	27708008
MAK21_YEAST	MAK21	genetic	27708008
GPI11_YEAST	GPI11	genetic	27708008
HSF_YEAST	HSF1	genetic	27708008
CDC23_YEAST	CDC23	genetic	27708008
RHO3_YEAST	RHO3	genetic	27708008
MED14_YEAST	RGR1	genetic	27708008
PRP24_YEAST	PRP24	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
2A5D_YEAST	RTS1	genetic	29644457
SGO1_YEAST	SGO1	genetic	29644457

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPO13_YEAST

Related Literatures of Post-Translational Modification