RE114_YEAST - dbPTM
RE114_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RE114_YEAST
UniProt AC P32841
Protein Name Meiotic recombination protein REC114
Gene Name REC114
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 428
Subcellular Localization Nucleus . Chromosome . Localizes to chromosomes.
Protein Description Required for the production of double-strand breaks (DSBs) in meiotic recombination initiation; not required for mitosis. Plays a role in activation of the DSB nuclease SPO11 at recombination hotspots. Prevents accumulation of meiotic double strand break intermediates and is needed for the proper timing of the first meiotic division. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation..
Protein Sequence MYEYCSVVIKKYSKYTIPSFAPNGFQSMLEPPQIDKWQHLSANCTLQFRVLLMDSRQILINVVLNNSTLLENIRLPLGDNQDLIQFSCKSPIISCKYISEEFGPRMLRRFQMNLPNDVEFNRTVVSLKNLNFVLRTARTSIAQSTITSQVQGNNNGTKVCFTEGPKVSSYTNPNTQFQTQNMIMDFSQRYQEESERESNNRSNITLPHDSIQIAQQIWPNTDLNVVQSSQDLNTPMATQTVLGRPESLIVQPLEVSQSPPNTTNCLPNAENKKKKVDTTSDFTSRKEIALCKTGLLETIHIPKERESQMQSVTGLDATPTIIWSPGKDNTAKKNTSNKKNIDDKLTNPQKSGNTHTPDRNKEVLPNGTLNETRKEASPSEGLTIRVKNVNRNASRKISKRLIKEKLKDEEFMKWVNKVETVLNKMFEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
280PhosphorylationKKKVDTTSDFTSRKE
CCCCCCCCCCCCHHH		32.5928889911
283PhosphorylationVDTTSDFTSRKEIAL
CCCCCCCCCHHHHHH		32.3928889911
284PhosphorylationDTTSDFTSRKEIALC
CCCCCCCCHHHHHHC		41.1528889911
335PhosphorylationDNTAKKNTSNKKNID
CCCCCCCCCCCCCCC		42.4227017623
336PhosphorylationNTAKKNTSNKKNIDD
CCCCCCCCCCCCCCH		56.9227017623
377PhosphorylationNETRKEASPSEGLTI
CCCCCCCCCCCCCEE		30.0127214570
379PhosphorylationTRKEASPSEGLTIRV
CCCCCCCCCCCEEEE		41.6327214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RE114_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RE114_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RE114_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MEI4_YEASTMEI4physical
14992724
RE107_YEASTREC107physical
14992724
RE104_YEASTREC104physical
14992724
RE114_YEASTREC114physical
14992724
MEI4_YEASTMEI4physical
16783010
HO_YEASTHOgenetic
17314980
MEI4_YEASTMEI4physical
17558514
SPO13_YEASTSPO13genetic
8417989
SPO11_YEASTSPO11genetic
23825959
PCH2_YEASTPCH2genetic
23825959
MED20_YEASTSRB2genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
RTG3_YEASTRTG3genetic
27708008
TAPT1_YEASTEMP65genetic
27708008
MIP6_YEASTMIP6genetic
27708008
STB5_YEASTSTB5genetic
27708008
CTK1_YEASTCTK1genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
ORM2_YEASTORM2genetic
27708008
CST9_YEASTCST9genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RE114_YEAST

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory