MEI4_YEAST - dbPTM
MEI4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MEI4_YEAST
UniProt AC P29467
Protein Name Meiosis-specific protein MEI4
Gene Name MEI4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 408
Subcellular Localization Nucleus . Chromosome . Localizes to chromosomes.
Protein Description Required for meiotic induction of recombination, viable spore production and chromosome synapsis. Component of the MER2-MEI4-REC114 complex which seems to be required for meiotic double-strand break (DSB) formation..
Protein Sequence MSRGKLEDMEQKETSEVDWIICFALIQSRNPTLWKRALSRKKGDVEDVGALKSEKNLKINPRENSKHIYKWVAPFENGFLNNKSLFAHLEPIYNFLCQNKYKSFEDAVGLKELQSFSKDVSTADINNWFLPRYKILLKILSLKTKEIDFRGLSQVFQTLQILLVSHYSHRIDSDSSFKRTLIDVHVFNFIAKFLFNRILLKKNQNDPKWLQNFYDQGDGKHLCDKVDYKRLCSLHFTLIYSIINIQLIKIKTNQTFEPQILKYVSVLKLIEHILIIIESLIHVLIRFVSKHKLICINRKKAYCRVYLERELSLKKTYLKNFYSVISGVPEKELGGLLKILKIVILSLLETFESIEWQHLKPFLEKFPAHEISLQKKRKYIQAALLITAERNLIARFRLSRWFNETENI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
173PhosphorylationHYSHRIDSDSSFKRT
HCCCCCCCCCCHHHH		36.7028889911
175PhosphorylationSHRIDSDSSFKRTLI
CCCCCCCCCHHHHHH		41.4428889911
176PhosphorylationHRIDSDSSFKRTLID
CCCCCCCCHHHHHHH		39.5128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MEI4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MEI4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MEI4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPO13_YEASTSPO13genetic
2693205
RE114_YEASTREC114physical
17558514
TO6BL_YEASTREC102physical
17558514
RE104_YEASTREC104physical
17558514
STU1_YEASTSTU1genetic
27708008
MCM1_YEASTMCM1genetic
27708008
MCES_YEASTABD1genetic
27708008
NSE4_YEASTNSE4genetic
27708008
CDC37_YEASTCDC37genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
RPN12_YEASTRPN12genetic
27708008
GPI10_YEASTGPI10genetic
27708008
MED14_YEASTRGR1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
SEC22_YEASTSEC22genetic
27708008
SEN1_YEASTSEN1genetic
27708008
ORC1_YEASTORC1genetic
27708008
LST8_YEASTLST8genetic
27708008
RPB2_YEASTRPB2genetic
27708008
APC5_YEASTAPC5genetic
27708008
BUR1_YEASTSGV1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MEI4_YEAST

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Related Literatures of Post-Translational Modification

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