| UniProt ID | STU1_YEAST | |
|---|---|---|
| UniProt AC | P38198 | |
| Protein Name | Protein STU1 | |
| Gene Name | STU1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1513 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Localizes to kinetochore microtubules and to the overlapping microtubules of the spindle midzone. | |
| Protein Description | Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for separation of the spindle poles during mitotic spindle formation. May cross-link overlapping antiparallel microtubules in the spindle midzone.. | |
| Protein Sequence | MSSFNNETNNNSNTNTHPDDSFPLYTVFKDESVPIEEKMALLTRFKGHVKKELVNESSIQAYFAALLFISGHYAYRSYPRLIFLSHSSLCYLIKRVAMQSPVQFNDTLVEQLLNHLIFELPNEKKFWLASIKAIEAIYLVNPSKIQAILANFLRRPSENQNGDYLNRIKSTLLTIDELIQINEKNNSNHLQLLRFFMLSFTNLLNNNLNEHANDDNNNVIIELIFDIMYKYLKMDDENSQDLIDGFINDLEVEKFKQKFISLAKSQDQHGSQEDKSTLFDEEYEFQLLLAEAKLPQLSNNLSSKDPAMKKNYESLNQLQQDLENLLAPFQSVKETEQNWKLRQSNIIELDNIISGNIPKDNPEEFVTVIKEVQLIELISRATSSLRTTLSLTALLFLKRLIHILNDQLPLSILDQIFVIFKNLLSSTKKISSQTAFHCLITLIIDINHFHNKLFQLSFLLINEKTVTPRFCSAILLRSFLIKFNDSNLSLNNSNTTSPTSKLENNIIYIEEWLKKGISDSQTTVREAMRLTFWYFYKCYPTNAKRLLSSSFSPQLKKATELAIPAHLNINYQVSRVSSTASASSATSRLYSHSSNNSSRKTSLLEQKRNYPSYAQPTQSSSTSLLNAPAVTAGGSVIASKLSNKLKTNLRSTSEYSSKENEKRARHHDSMNSVSNSNTKDNNNVTKRKVSAPPSSTAATKVSENYTNFDDFPSNQIDLTDELSNSYSNPLIKKYMDKNDVSMSSSPISLKGSNKLGEYETLYKKFNDASFPAQIKDALQYLQKELLLTSQQSSSAPKFEFPMIMKKLRQIMIKSPNDFKPFLSIEKFTNGVPLNYLIELYSINSFDYAEILKNRMNPEKPYELTNLIITIADLFNFLNANNCPNDFKLYYMKYKTTFFNYNFKLLLEIFRNLNIKHDNTLRSGTNDLMPKISMILFQIYGKEFDYTCYFNLIFEIYKFDNNRFNKLLADFDIVSTKMKICHELEKKDANFKVEDIISRESSVSFTPIDNKKSEGDEESDDAVDENDVKKCMEMTMINPFKNLETDKTLELKNNVGKRTSSTDSVVIHDDNDKDKKLSEMTKIVSVYQLDQPNPAKEEDDIDMENSQKSDLNLSEIFQNSGENTERKLKDDNEPTVKFSTDPPKIINEPEKLIGNGNENEKPDLETMSPIKINGDENMGQKQRITVKRERDVALTEQDINSKKMKLVNNKKSEKMHLLIMDNFPRDSLTVYEISHLLMVDSNGNTLMDFDVYFNHMSKAINRIKSGSFTMKHINYLIEPLITCFQNQKMTDWLTNENGFDELLDVAIMLLKSTDDTPSIPSKISSKSIILVHCLLVWKKFLNTLSENADDDGVSVRMCFEEVWEQILLMLNKFSDYGNEIYKLAQEFRDSLMLSHFFKKHSATRILSMLVTEIQPDTAGVKETFLIETLWKMLQSPTICQQFKKSNISEIIQTMSYFIMGTDNTSWNFTSAVVLARCLRVLQTTPDYTEQETERLFDCLPKNVFKMIMFIASNE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSFNNETN ------CCCCCCCCC | 55.74 | 27017623 | |
| 3 | Phosphorylation | -----MSSFNNETNN -----CCCCCCCCCC | 43.80 | 19779198 | |
| 16 | Phosphorylation | NNNSNTNTHPDDSFP CCCCCCCCCCCCCCC | 32.52 | 27017623 | |
| 21 | Phosphorylation | TNTHPDDSFPLYTVF CCCCCCCCCCEEEEE | 35.82 | 27017623 | |
| 25 | Phosphorylation | PDDSFPLYTVFKDES CCCCCCEEEEECCCC | 10.90 | 19779198 | |
| 26 | Phosphorylation | DDSFPLYTVFKDESV CCCCCEEEEECCCCC | 27.44 | 27017623 | |
| 271 | Phosphorylation | KSQDQHGSQEDKSTL HCCCCCCCCCCHHHC | 28.42 | 28889911 | |
| 276 | Phosphorylation | HGSQEDKSTLFDEEY CCCCCCHHHCCCHHH | 42.54 | 28889911 | |
| 277 | Phosphorylation | GSQEDKSTLFDEEYE CCCCCHHHCCCHHHH | 36.87 | 19779198 | |
| 387 | Phosphorylation | RATSSLRTTLSLTAL HHCHHHHHHHHHHHH | 37.06 | 30377154 | |
| 388 | Phosphorylation | ATSSLRTTLSLTALL HCHHHHHHHHHHHHH | 14.12 | 30377154 | |
| 390 | Phosphorylation | SSLRTTLSLTALLFL HHHHHHHHHHHHHHH | 22.91 | 21440633 | |
| 392 | Phosphorylation | LRTTLSLTALLFLKR HHHHHHHHHHHHHHH | 16.34 | 21440633 | |
| 496 | Phosphorylation | SLNNSNTTSPTSKLE CCCCCCCCCCCHHHH | 36.64 | 28889911 | |
| 497 | Phosphorylation | LNNSNTTSPTSKLEN CCCCCCCCCCHHHHC | 24.92 | 28889911 | |
| 499 | Phosphorylation | NSNTTSPTSKLENNI CCCCCCCCHHHHCCE | 37.96 | 27017623 | |
| 548 | Phosphorylation | TNAKRLLSSSFSPQL CCHHHHHCCCCCHHH | 28.64 | 17287358 | |
| 577 | Phosphorylation | NYQVSRVSSTASASS EEEEEEECCCCCCCH | 22.36 | 30377154 | |
| 578 | Phosphorylation | YQVSRVSSTASASSA EEEEEECCCCCCCHH | 25.74 | 28889911 | |
| 591 | Phosphorylation | SATSRLYSHSSNNSS HHHHHHHHCCCCCCC | 22.83 | 19779198 | |
| 593 | Phosphorylation | TSRLYSHSSNNSSRK HHHHHHCCCCCCCCC | 28.90 | 19779198 | |
| 594 | Phosphorylation | SRLYSHSSNNSSRKT HHHHHCCCCCCCCCC | 34.31 | 23749301 | |
| 597 | Phosphorylation | YSHSSNNSSRKTSLL HHCCCCCCCCCCHHH | 35.45 | 28889911 | |
| 598 | Phosphorylation | SHSSNNSSRKTSLLE HCCCCCCCCCCHHHH | 39.66 | 30377154 | |
| 601 | Phosphorylation | SNNSSRKTSLLEQKR CCCCCCCCHHHHHHH | 24.40 | 19779198 | |
| 602 | Phosphorylation | NNSSRKTSLLEQKRN CCCCCCCHHHHHHHC | 33.71 | 23749301 | |
| 651 | Phosphorylation | KLKTNLRSTSEYSSK HHHHCCCCCCCCCCH | 39.18 | 23749301 | |
| 652 | Phosphorylation | LKTNLRSTSEYSSKE HHHCCCCCCCCCCHH | 21.10 | 21440633 | |
| 653 | Phosphorylation | KTNLRSTSEYSSKEN HHCCCCCCCCCCHHH | 35.47 | 20377248 | |
| 669 | Phosphorylation | KRARHHDSMNSVSNS HHHHCHHCCHHCCCC | 18.59 | 30377154 | |
| 690 | Phosphorylation | NVTKRKVSAPPSSTA CCCCEEECCCCCCHH | 37.79 | 19823750 | |
| 694 | Phosphorylation | RKVSAPPSSTAATKV EEECCCCCCHHCCHH | 38.98 | 21440633 | |
| 695 | Phosphorylation | KVSAPPSSTAATKVS EECCCCCCHHCCHHC | 28.04 | 21440633 | |
| 696 | Phosphorylation | VSAPPSSTAATKVSE ECCCCCCHHCCHHCC | 25.34 | 19823750 | |
| 699 | Phosphorylation | PPSSTAATKVSENYT CCCCHHCCHHCCCCC | 29.52 | 19823750 | |
| 719 | Phosphorylation | PSNQIDLTDELSNSY CHHCCCCCHHHCHHC | 24.55 | 21440633 | |
| 725 | Phosphorylation | LTDELSNSYSNPLIK CCHHHCHHCCCHHHH | 26.94 | 21440633 | |
| 734 | Phosphorylation | SNPLIKKYMDKNDVS CCHHHHHHCCCCCCC | 12.92 | 21440633 | |
| 741 | Phosphorylation | YMDKNDVSMSSSPIS HCCCCCCCCCCCCCC | 18.79 | 21440633 | |
| 743 | Phosphorylation | DKNDVSMSSSPISLK CCCCCCCCCCCCCCC | 21.84 | 24961812 | |
| 744 | Phosphorylation | KNDVSMSSSPISLKG CCCCCCCCCCCCCCC | 31.34 | 21440633 | |
| 745 | Phosphorylation | NDVSMSSSPISLKGS CCCCCCCCCCCCCCC | 20.95 | 21440633 | |
| 748 | Phosphorylation | SMSSSPISLKGSNKL CCCCCCCCCCCCCCC | 27.67 | 24961812 | |
| 789 | Phosphorylation | QKELLLTSQQSSSAP HHHHHHHCCCCCCCC | 26.62 | 30377154 | |
| 792 | Phosphorylation | LLLTSQQSSSAPKFE HHHHCCCCCCCCCCC | 20.72 | 30377154 | |
| 819 | Acetylation | IKSPNDFKPFLSIEK CCCCCCCCCCEEEEC | 37.41 | 24489116 | |
| 924 | Phosphorylation | DNTLRSGTNDLMPKI CCCCCCCCCCHHHHH | 27.14 | 19779198 | |
| 939 | Phosphorylation | SMILFQIYGKEFDYT HHHHHHHHCCCCCEE | 16.03 | 19779198 | |
| 997 | Phosphorylation | FKVEDIISRESSVSF CCHHHHHCCCCCEEE | 30.26 | 21551504 | |
| 1000 | Phosphorylation | EDIISRESSVSFTPI HHHHCCCCCEEEEEC | 34.62 | 28889911 | |
| 1001 | Phosphorylation | DIISRESSVSFTPID HHHCCCCCEEEEECC | 19.61 | 20377248 | |
| 1003 | Phosphorylation | ISRESSVSFTPIDNK HCCCCCEEEEECCCC | 25.92 | 28889911 | |
| 1012 | Phosphorylation | TPIDNKKSEGDEESD EECCCCCCCCCCCCC | 48.71 | 29136822 | |
| 1018 | Phosphorylation | KSEGDEESDDAVDEN CCCCCCCCCCCCCHH | 38.45 | 25521595 | |
| 1034 | Phosphorylation | VKKCMEMTMINPFKN HHHHHHHHCCCCCCC | 11.12 | 21440633 | |
| 1044 | Phosphorylation | NPFKNLETDKTLELK CCCCCCCCCCEEEEE | 46.06 | 28889911 | |
| 1047 | Phosphorylation | KNLETDKTLELKNNV CCCCCCCEEEEECCC | 28.42 | 21551504 | |
| 1058 | Phosphorylation | KNNVGKRTSSTDSVV ECCCCCCCCCCCEEE | 30.43 | 29136822 | |
| 1059 | Phosphorylation | NNVGKRTSSTDSVVI CCCCCCCCCCCEEEE | 34.96 | 29136822 | |
| 1060 | Phosphorylation | NVGKRTSSTDSVVIH CCCCCCCCCCEEEEE | 35.30 | 19823750 | |
| 1061 | Phosphorylation | VGKRTSSTDSVVIHD CCCCCCCCCEEEEEC | 31.87 | 29136822 | |
| 1063 | Phosphorylation | KRTSSTDSVVIHDDN CCCCCCCEEEEECCC | 20.55 | 17287358 | |
| 1105 | Phosphorylation | DDIDMENSQKSDLNL CCCCCCCCCCCCCCH | 26.19 | 28889911 | |
| 1108 | Phosphorylation | DMENSQKSDLNLSEI CCCCCCCCCCCHHHH | 39.43 | 22369663 | |
| 1113 | Phosphorylation | QKSDLNLSEIFQNSG CCCCCCHHHHHHCCC | 27.80 | 23749301 | |
| 1134 | Phosphorylation | LKDDNEPTVKFSTDP CCCCCCCCCCCCCCC | 30.10 | 21440633 | |
| 1165 | Phosphorylation | NEKPDLETMSPIKIN CCCCCCCCCCCEEEC | 30.19 | 20377248 | |
| 1167 | Phosphorylation | KPDLETMSPIKINGD CCCCCCCCCEEECCC | 30.78 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STU1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STU1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STU1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-276; THR-496; SER-497;SER-690; SER-997; SER-1000; SER-1001; SER-1018; THR-1047 AND SER-1167,AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1018, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548; SER-690; SER-1060AND SER-1063, AND MASS SPECTROMETRY. | |
