HAS1_YEAST - dbPTM
HAS1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAS1_YEAST
UniProt AC Q03532
Protein Name ATP-dependent RNA helicase HAS1
Gene Name HAS1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 505
Subcellular Localization Nucleus, nucleolus .
Protein Description ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA..
Protein Sequence MATPSNKRSRDSESTEEPVVDEKSTSKQNNAAPEGEQTTCVEKFEELKLSQPTLKAIEKMGFTTMTSVQARTIPPLLAGRDVLGAAKTGSGKTLAFLIPAIELLHSLKFKPRNGTGIIVITPTRELALQIFGVARELMEFHSQTFGIVIGGANRRQEAEKLMKGVNMLIATPGRLLDHLQNTKGFVFKNLKALIIDEADRILEIGFEDEMRQIIKILPNEDRQSMLFSATQTTKVEDLARISLRPGPLFINVVPETDNSTADGLEQGYVVCDSDKRFLLLFSFLKRNQKKKIIVFLSSCNSVKYYAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAERGILICTDVAARGLDIPAVDWIIQFDPPDDPRDYIHRVGRTARGTKGKGKSLMFLTPNELGFLRYLKASKVPLNEYEFPENKIANVQSQLEKLIKSNYYLHQTAKDGYRSYLQAYASHSLKTVYQIDKLDLAKVAKSYGFPVPPKVNITIGASGKTPNTKRRKTHK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationATPSNKRSRDSESTE
CCCCCCCCCCCCCCC		41.8929136822
12PhosphorylationSNKRSRDSESTEEPV
CCCCCCCCCCCCCCC		32.1325521595
14PhosphorylationKRSRDSESTEEPVVD
CCCCCCCCCCCCCCC		45.1019823750
15PhosphorylationRSRDSESTEEPVVDE
CCCCCCCCCCCCCCC		40.0725752575
24PhosphorylationEPVVDEKSTSKQNNA
CCCCCCCCCCCCCCC		35.5519779198
26PhosphorylationVVDEKSTSKQNNAAP
CCCCCCCCCCCCCCC		39.0630377154
43UbiquitinationEQTTCVEKFEELKLS
CCCCHHHHHHHHCCC		37.3623749301
48AcetylationVEKFEELKLSQPTLK
HHHHHHHCCCCHHHH		49.7422865919
55UbiquitinationKLSQPTLKAIEKMGF
CCCCHHHHHHHHCCC		50.2023749301
87UbiquitinationRDVLGAAKTGSGKTL
CCEECCCCCCCCHHH		53.5423749301
115PhosphorylationKFKPRNGTGIIVITP
CCCCCCCCCEEEEEC		28.8527017623
121PhosphorylationGTGIIVITPTRELAL
CCCEEEEECCHHHHH		14.0227017623
123PhosphorylationGIIVITPTRELALQI
CEEEEECCHHHHHHH		28.2927017623
188AcetylationNTKGFVFKNLKALII
HCCCHHHCCCEEEEE		56.9524489116
215AcetylationDEMRQIIKILPNEDR
HHHHHHHHHCCCCCH		39.5624489116
275UbiquitinationYVVCDSDKRFLLLFS
EEEECCCHHHHHHHH		49.3417644757
322AcetylationPVLELHGKQKQQKRT
HHHHHCCCHHHHHHH		43.5025381059
389AcetylationRGTKGKGKSLMFLTP
CCCCCCCCCCEEECH		43.8524489116
421AcetylationEYEFPENKIANVQSQ
CCCCCCHHHHHHHHH		41.3524489116
427PhosphorylationNKIANVQSQLEKLIK
HHHHHHHHHHHHHHH		32.2419823750
431AcetylationNVQSQLEKLIKSNYY
HHHHHHHHHHHCCCC		65.1924489116
431UbiquitinationNVQSQLEKLIKSNYY
HHHHHHHHHHHCCCC		65.1924961812
434AcetylationSQLEKLIKSNYYLHQ
HHHHHHHHCCCCHHH		42.9824489116
444SuccinylationYYLHQTAKDGYRSYL
CCHHHHHHHHHHHHH		55.8923954790
444MethylationYYLHQTAKDGYRSYL
CCHHHHHHHHHHHHH		55.8920137074
444AcetylationYYLHQTAKDGYRSYL
CCHHHHHHHHHHHHH		55.8924489116
458PhosphorylationLQAYASHSLKTVYQI
HHHHHHCCCCEEEEE		29.1230377154
460UbiquitinationAYASHSLKTVYQIDK
HHHHCCCCEEEEECH		38.6717644757
467AcetylationKTVYQIDKLDLAKVA
CEEEEECHHHHHHHH		45.5924489116
467UbiquitinationKTVYQIDKLDLAKVA
CEEEEECHHHHHHHH		45.5917644757
472AcetylationIDKLDLAKVAKSYGF
ECHHHHHHHHHHHCC		50.4524489116
472UbiquitinationIDKLDLAKVAKSYGF
ECHHHHHHHHHHHCC		50.4517644757
492PhosphorylationVNITIGASGKTPNTK
EEEEECCCCCCCCCC		35.2927017623
494AcetylationITIGASGKTPNTKRR
EEECCCCCCCCCCCC		59.3122865919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAS1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAS1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAS1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HAS1_YEASTHAS1physical
23788678
RLP7_YEASTRLP7physical
23788678
NOP15_YEASTNOP15physical
23788678
LOC1_YEASTLOC1physical
25877921
RLP7_YEASTRLP7physical
25877921
MAK21_YEASTMAK21physical
25877921
ERB1_YEASTERB1physical
25877921
EBP2_YEASTEBP2physical
25877921
NOP4_YEASTNOP4physical
25877921
NSA2_YEASTNSA2physical
25877921
HAS1_YEASTHAS1physical
25877921
DBP10_YEASTDBP10physical
25877921
NOP15_YEASTNOP15physical
25877921
NOG2_YEASTNOG2physical
25877921
AAR2_YEASTAAR2genetic
27708008
CDC20_YEASTCDC20genetic
27708008
MAK16_YEASTMAK16genetic
27708008
CKS1_YEASTCKS1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
MED8_YEASTMED8genetic
27708008
ENP1_YEASTENP1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
UBC9_YEASTUBC9genetic
27708008
NSE4_YEASTNSE4genetic
27708008
CDC53_YEASTCDC53genetic
27708008
RPB1_YEASTRPO21genetic
27708008
NHP2_YEASTNHP2genetic
27708008
RS13_YEASTRPS13genetic
27708008
ERF3_YEASTSUP35genetic
27708008
PESC_YEASTNOP7genetic
27708008
MED6_YEASTMED6genetic
27708008
RRP4_YEASTRRP4genetic
27708008
CDC12_YEASTCDC12genetic
27708008
SHQ1_YEASTSHQ1genetic
27708008
ESS1_YEASTESS1genetic
27708008
MAK11_YEASTMAK11genetic
27708008
NOC3_YEASTNOC3genetic
27708008
TAD3_YEASTTAD3genetic
27708008
SEN1_YEASTSEN1genetic
27708008
MCM1_YEASTMCM1genetic
27708008
NOP2_YEASTNOP2genetic
27708008
NOG2_YEASTNOG2genetic
27708008
RRP44_YEASTDIS3genetic
27708008
BRX1_YEASTBRX1genetic
27708008
MED4_YEASTMED4genetic
27708008
DYR_YEASTDFR1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
ULP1_YEASTULP1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
NIP7_YEASTNIP7genetic
27708008
IF6_YEASTTIF6genetic
27708008
AIM4_YEASTAIM4genetic
27708008
SLX5_YEASTSLX5genetic
27708008
RRP8_YEASTRRP8genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
SGF73_YEASTSGF73genetic
27708008
MED20_YEASTSRB2genetic
27708008
LRP1_YEASTLRP1genetic
27708008
STB5_YEASTSTB5genetic
27708008
AIR1_YEASTAIR1genetic
27708008
LHS1_YEASTLHS1genetic
27708008
CTK1_YEASTCTK1genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
SIC1_YEASTSIC1genetic
27708008
DCAM_YEASTSPE2genetic
27708008
MET22_YEASTMET22genetic
27708008
RRP6_YEASTRRP6genetic
27708008
VAM3_YEASTVAM3genetic
27708008
ELG1_YEASTELG1genetic
27708008
PALA_YEASTRIM20genetic
27708008
MNE1_YEASTMNE1genetic
27708008
GDS1_YEASTGDS1genetic
27708008
CHL1_YEASTCHL1genetic
27708008
PTPA2_YEASTRRD2genetic
27708008
USV1_YEASTUSV1genetic
27708008
SPEE_YEASTSPE3genetic
27708008
NOP4_YEASTNOP4physical
27077951
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAS1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12 AND SER-14, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND MASSSPECTROMETRY.

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