dbPTM

NSA2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NSA2_YEAST
UniProt AC	P40078
Protein Name	Ribosome biogenesis protein NSA2
Gene Name	NSA2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	261
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles. Under normal, rapid growth conditions, high levels of NSA2 would allow the progression of pre-60S particles through the ITS2 processing..
Protein Sequence	MPQNDYIERHIKQHGKRLDHEERKRKREARESHKISERAQKLTGWKGKQFAKKRYAEKVSMRKKIKAHEQSKVKGSSKPLDTDGDALPTYLLDREQNNTAKAISSSIKQKRLEKADKFSVPLPKVRGISEEEMFKVIKTGKSRSKSWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELGVTVFLPILAVKKNPQSPMYTQLGVLTKGTIIEVNVSELGMVTAGGKVVWGKYAQVTNEPDRDGCVNAVLLV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Acetylation	IKQKRLEKADKFSVP HHHHHHHHCCCCCCC	67.49	25381059
117	Acetylation	KRLEKADKFSVPLPK HHHHHCCCCCCCCCC	44.38	24489116
129	Phosphorylation	LPKVRGISEEEMFKV CCCCCCCCHHHHHHH	41.60	21440633
135	Acetylation	ISEEEMFKVIKTGKS CCHHHHHHHHHCCCC	41.56	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NSA2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NSA2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NSA2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IF6_YEAST	TIF6	physical	11805826
ERB1_YEAST	ERB1	physical	11805826
HAS1_YEAST	HAS1	physical	11805826
MRT4_YEAST	MRT4	physical	11805826
NOG1_YEAST	NOG1	physical	11805826
RLP7_YEAST	RLP7	physical	11805826
SDA1_YEAST	SDA1	physical	11805826
NLE1_YEAST	RSA4	physical	11805826
ARX1_YEAST	ARX1	physical	11805826
NUG1_YEAST	NUG1	physical	11805826
RIX1_YEAST	RIX1	physical	11805826
NOG2_YEAST	NOG2	physical	11805826
NOC2_YEAST	NOC2	physical	11805826
ARX1_YEAST	ARX1	physical	16429126
ERB1_YEAST	ERB1	physical	16429126
MRT4_YEAST	MRT4	physical	16429126
NOC2_YEAST	NOC2	physical	16429126
NOG1_YEAST	NOG1	physical	16429126
NUG1_YEAST	NUG1	physical	16429126
RLP7_YEAST	RLP7	physical	16429126
RL3_YEAST	RPL3	physical	16429126
SDA1_YEAST	SDA1	physical	16429126
IF6_YEAST	TIF6	physical	16429126
NOG2_YEAST	NOG2	physical	16429126
RIX1_YEAST	RIX1	physical	16429126
NLE1_YEAST	RSA4	physical	16429126
HAS1_YEAST	HAS1	physical	16429126
RL4B_YEAST	RPL4B	physical	16429126
NSA2_YEAST	NSA2	physical	16861225
NOG1_YEAST	NOG1	physical	16861225
IF6_YEAST	TIF6	physical	16861225
PESC_YEAST	NOP7	physical	16861225
NOG2_YEAST	NOG2	physical	16861225
RLP24_YEAST	RLP24	physical	16861225
RL5_YEAST	RPL5	physical	16861225
NIP7_YEAST	NIP7	physical	18467557
EBP2_YEAST	EBP2	physical	18467557
CGR1_YEAST	CGR1	physical	18467557
LSP1_YEAST	LSP1	physical	18719252
CGR1_YEAST	CGR1	physical	22615397
NOP4_YEAST	NOP4	physical	25877921
NOP15_YEAST	NOP15	physical	25877921
LOC1_YEAST	LOC1	physical	25877921
MAK21_YEAST	MAK21	physical	25877921
EBP2_YEAST	EBP2	physical	25877921
NOP4_YEAST	NOP4	physical	27077951
DVL2_HUMAN	DVL2	physical	27107014
NLE1_YEAST	RSA4	physical	25404745

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NSA2_YEAST

Related Literatures of Post-Translational Modification