| UniProt ID | RIX1_YEAST | |
|---|---|---|
| UniProt AC | P38883 | |
| Protein Name | Pre-rRNA-processing protein RIX1 | |
| Gene Name | RIX1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 763 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. [PubMed: 11313466] | |
| Protein Sequence | MSEEFIAVSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGGQLLAAIYSRLEQKTGFYSSVISSSHGKQLFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPVLQRILKRNTTTFKPFTNKFRTVLINLIISDYASLGTKTQRLVCENFAYLHLLKIQVSDTSDDETQAHHKIYADSNWRTGLMSILSQFKPIIQLCGEILDFEQDNELYKLIKSLPVIDESNNKEEFLPSLKLDFNAPLTLWEIPQRLSLLADMLVAFISLPTPFPIRVPLGGINSLCEVLLGVSNKYLPLKKELRHDNELNGVINTILPQIQFQGIRLWEIMVSKYGKCGLSFFEGILSSIELFIPLKKKSNNEIDFNVVGSLKFEFATVFRLVNMILSHLGHQLNIISVISQLIEVALFLSHDKTLIDSLFKNRKSIMKQQTKTKQSKRSKSAEGAFSDIYTHPELFVCKNSMNWFNEINDFFITALNNWILPSTPHIQILKYSITQSLRLKERFGYIPESFVNLLRCEVLHPGSERVSILPIAISLLKNINDDMFELLCHPKVPVGMVYQLHKPLDLGEDGEVRDDINKKEVETNESSSNANTGLETLKALENLENVTIPEPKHEVPKVVDDTAIFKKRSVEEVIERESTSSHKKVKFVEETTVDNGEELIVKKAVSQTKEEEKPMEDSEDEEQEEFEIPAIELSDDEEEEEEEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEEFIAVS ------CCHHHHHHH | 45.92 | 22814378 | |
| 224 | Phosphorylation | HLLKIQVSDTSDDET EEEEEEECCCCCCCH | 20.85 | 30377154 | |
| 226 | Phosphorylation | LKIQVSDTSDDETQA EEEEECCCCCCCHHH | 26.92 | 27717283 | |
| 227 | Phosphorylation | KIQVSDTSDDETQAH EEEECCCCCCCHHHH | 48.32 | 27717283 | |
| 231 | Phosphorylation | SDTSDDETQAHHKIY CCCCCCCHHHHHHEE | 37.74 | 27717283 | |
| 236 | Acetylation | DETQAHHKIYADSNW CCHHHHHHEECCCCH | 27.78 | 24489116 | |
| 286 | Phosphorylation | SLPVIDESNNKEEFL CCCEECCCCCCCCCC | 41.79 | 17287358 | |
| 486 | Acetylation | KNRKSIMKQQTKTKQ HCHHHHHHHHHHHHH | 37.27 | 25381059 | |
| 490 | Acetylation | SIMKQQTKTKQSKRS HHHHHHHHHHHHHHH | 49.76 | 25381059 | |
| 497 | Phosphorylation | KTKQSKRSKSAEGAF HHHHHHHHHHCCCCC | 34.40 | 30377154 | |
| 499 | Phosphorylation | KQSKRSKSAEGAFSD HHHHHHHHCCCCCCC | 32.57 | 21440633 | |
| 555 | Phosphorylation | LKYSITQSLRLKERF EEEEHHHHHHHHHHH | 13.55 | 25521595 | |
| 645 | Phosphorylation | KEVETNESSSNANTG HEECCCCCCCCCHHH | 40.93 | 30377154 | |
| 647 | Phosphorylation | VETNESSSNANTGLE ECCCCCCCCCHHHHH | 49.60 | 23749301 | |
| 676 | Acetylation | EPKHEVPKVVDDTAI CCCCCCCCCCCCCHH | 61.13 | 24489116 | |
| 685 | Acetylation | VDDTAIFKKRSVEEV CCCCHHHHCCCHHHH | 40.96 | 22865919 | |
| 688 | Phosphorylation | TAIFKKRSVEEVIER CHHHHCCCHHHHHHH | 42.64 | 23749301 | |
| 737 | Phosphorylation | EEKPMEDSEDEEQEE CCCCCCCCCCHHHHH | 33.37 | 21551504 | |
| 753 | Phosphorylation | EIPAIELSDDEEEEE CCCCEECCCCHHHHH | 30.17 | 21551504 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RIX1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RIX1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RIX1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286, AND MASSSPECTROMETRY. | |
