RL9A_YEAST - dbPTM
RL9A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RL9A_YEAST
UniProt AC P05738
Protein Name 60S ribosomal protein L9-A {ECO:0000303|PubMed:9559554}
Gene Name RPL9A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 191
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MKYIQTEQQIEVPEGVTVSIKSRIVKVVGPRGTLTKNLKHIDVTFTKVNNQLIKVAVHNGGRKHVAALRTVKSLVDNMITGVTKGYKYKMRYVYAHFPINVNIVEKDGAKFIEVRNFLGDKKIRNVPVRDGVTIEFSTNVKDEIVLSGNSVEDVSQNAADLQQICRVRNKDIRKFLDGIYVSHKGFITEDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKYIQTEQQ
------CCEECEEEE		51.5723749301
3Phosphorylation-----MKYIQTEQQI
-----CCEECEEEEE		9.2830377154
6Phosphorylation--MKYIQTEQQIEVP
--CCEECEEEEEECC		26.6330377154
17PhosphorylationIEVPEGVTVSIKSRI
EECCCCCEEEEECCE		21.2829136822
19PhosphorylationVPEGVTVSIKSRIVK
CCCCCEEEEECCEEE		18.2230377154
21UbiquitinationEGVTVSIKSRIVKVV
CCCEEEEECCEEEEE		26.6123749301
21AcetylationEGVTVSIKSRIVKVV
CCCEEEEECCEEEEE		26.6124489116
21SuccinylationEGVTVSIKSRIVKVV
CCCEEEEECCEEEEE		26.6123954790
26UbiquitinationSIKSRIVKVVGPRGT
EEECCEEEEECCCCC		28.9123749301
262-HydroxyisobutyrylationSIKSRIVKVVGPRGT
EEECCEEEEECCCCC		28.91-
26AcetylationSIKSRIVKVVGPRGT
EEECCEEEEECCCCC		28.9122865919
362-HydroxyisobutyrylationGPRGTLTKNLKHIDV
CCCCCCCCCCCEEEE		64.49-
36UbiquitinationGPRGTLTKNLKHIDV
CCCCCCCCCCCEEEE		64.4922817900
36AcetylationGPRGTLTKNLKHIDV
CCCCCCCCCCCEEEE		64.4924489116
36SuccinylationGPRGTLTKNLKHIDV
CCCCCCCCCCCEEEE		64.4923954790
39UbiquitinationGTLTKNLKHIDVTFT
CCCCCCCCEEEEEEE		48.1623749301
39AcetylationGTLTKNLKHIDVTFT
CCCCCCCCEEEEEEE		48.1624489116
392-HydroxyisobutyrylationGTLTKNLKHIDVTFT
CCCCCCCCEEEEEEE		48.16-
47UbiquitinationHIDVTFTKVNNQLIK
EEEEEEEEECCEEEE		38.4823749301
47AcetylationHIDVTFTKVNNQLIK
EEEEEEEEECCEEEE		38.4824489116
54AcetylationKVNNQLIKVAVHNGG
EECCEEEEEEEECCC		32.5024489116
632-HydroxyisobutyrylationAVHNGGRKHVAALRT
EEECCCHHHHHHHHH		45.78-
70PhosphorylationKHVAALRTVKSLVDN
HHHHHHHHHHHHHHH		32.8930377154
722-HydroxyisobutyrylationVAALRTVKSLVDNMI
HHHHHHHHHHHHHHH		37.14-
72UbiquitinationVAALRTVKSLVDNMI
HHHHHHHHHHHHHHH		37.1417644757
72AcetylationVAALRTVKSLVDNMI
HHHHHHHHHHHHHHH		37.1424489116
73PhosphorylationAALRTVKSLVDNMIT
HHHHHHHHHHHHHHH		29.3228152593
80PhosphorylationSLVDNMITGVTKGYK
HHHHHHHHCCCCCCE		18.1628152593
83PhosphorylationDNMITGVTKGYKYKM
HHHHHCCCCCCEEEE		21.7930377154
84SuccinylationNMITGVTKGYKYKMR
HHHHCCCCCCEEEEE		58.8123954790
84AcetylationNMITGVTKGYKYKMR
HHHHCCCCCCEEEEE		58.8124489116
84UbiquitinationNMITGVTKGYKYKMR
HHHHCCCCCCEEEEE		58.8123749301
87UbiquitinationTGVTKGYKYKMRYVY
HCCCCCCEEEEEEEE		47.2522817900
89UbiquitinationVTKGYKYKMRYVYAH
CCCCCEEEEEEEEEE		16.8522817900
106SuccinylationINVNIVEKDGAKFIE
EEEEEEECCCCEEEE		51.0423954790
106UbiquitinationINVNIVEKDGAKFIE
EEEEEEECCCCEEEE		51.0423749301
106AcetylationINVNIVEKDGAKFIE
EEEEEEECCCCEEEE		51.0424489116
1062-HydroxyisobutyrylationINVNIVEKDGAKFIE
EEEEEEECCCCEEEE		51.04-
110UbiquitinationIVEKDGAKFIEVRNF
EEECCCCEEEEEEEC		53.0223749301
110AcetylationIVEKDGAKFIEVRNF
EEECCCCEEEEEEEC		53.0224489116
1102-HydroxyisobutyrylationIVEKDGAKFIEVRNF
EEECCCCEEEEEEEC		53.02-
121AcetylationVRNFLGDKKIRNVPV
EEECCCCCCCCCCEE		48.5825381059
121UbiquitinationVRNFLGDKKIRNVPV
EEECCCCCCCCCCEE		48.5823749301
122UbiquitinationRNFLGDKKIRNVPVR
EECCCCCCCCCCEEC		52.1922817900
133PhosphorylationVPVRDGVTIEFSTNV
CEECCCEEEEEECCC		21.9627017623
137PhosphorylationDGVTIEFSTNVKDEI
CCEEEEEECCCCCEE		13.2927017623
138PhosphorylationGVTIEFSTNVKDEIV
CEEEEEECCCCCEEE		49.7227017623
147PhosphorylationVKDEIVLSGNSVEDV
CCCEEEECCCCHHHH		25.6530377154
150PhosphorylationEIVLSGNSVEDVSQN
EEEECCCCHHHHHHC		30.3430377154
174AcetylationVRNKDIRKFLDGIYV
HCCHHHHHHHCEEEE		51.0824489116
1742-HydroxyisobutyrylationVRNKDIRKFLDGIYV
HCCHHHHHHHCEEEE		51.08-
174UbiquitinationVRNKDIRKFLDGIYV
HCCHHHHHHHCEEEE		51.0817644757
180PhosphorylationRKFLDGIYVSHKGFI
HHHHCEEEEEECCCC		11.0528889911
182PhosphorylationFLDGIYVSHKGFITE
HHCEEEEEECCCCCC		11.5121440633
184UbiquitinationDGIYVSHKGFITEDL
CEEEEEECCCCCCCC		48.2723749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RL9A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RL9A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RL9A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RL9B_YEASTRPL9Bgenetic
22377630
UBC3_YEASTCDC34genetic
27708008
RRP1_YEASTRRP1genetic
27708008
CDC37_YEASTCDC37genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
RMRP_YEASTSNM1genetic
27708008
PSB7_YEASTPRE4genetic
27708008
ARP4_YEASTARP4genetic
27708008
ARP3_YEASTARP3genetic
27708008
RSC4_YEASTRSC4genetic
27708008
NOP56_YEASTNOP56genetic
27708008
UTP13_YEASTUTP13genetic
27708008
CAP_YEASTSRV2genetic
27708008
CLP1_YEASTCLP1genetic
27708008
MYO2_YEASTMYO2genetic
27708008
SEC62_YEASTSEC62genetic
27708008
RS10B_YEASTRPS10Bgenetic
27708008
SEC17_YEASTSEC17genetic
27708008
ORC2_YEASTORC2genetic
27708008
CDK1_YEASTCDC28genetic
27708008
NOT1_YEASTCDC39genetic
27708008
CDC7_YEASTCDC7genetic
27708008
DPOD_YEASTPOL3genetic
27708008
CDC53_YEASTCDC53genetic
27708008
COPA_YEASTCOP1genetic
27708008
YRB1_YEASTYRB1genetic
27708008
DAD1_YEASTDAD1genetic
27708008
TAF12_YEASTTAF12genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PCF11_YEASTPCF11genetic
27708008
NSE3_YEASTNSE3genetic
27708008
UTP5_YEASTUTP5genetic
27708008
SMT3_YEASTSMT3genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
SAD1_YEASTSAD1genetic
27708008
DNA2_YEASTDNA2genetic
27708008
MET30_YEASTMET30genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
ESS1_YEASTESS1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
MIF2_YEASTMIF2genetic
27708008
PRP19_YEASTPRP19genetic
27708008
CDC3_YEASTCDC3genetic
27708008
RLA0_YEASTRPP0genetic
27708008
SC61A_YEASTSEC61genetic
27708008
NBP1_YEASTNBP1genetic
27708008
POB3_YEASTPOB3genetic
27708008
ERO1_YEASTERO1genetic
27708008
PDS5_YEASTPDS5genetic
27708008
MED11_YEASTMED11genetic
27708008
RNT1_YEASTRNT1genetic
27708008
LCB1_YEASTLCB1genetic
27708008
TRM6_YEASTGCD10genetic
27708008
SPC98_YEASTSPC98genetic
27708008
CH10_YEASTHSP10genetic
27708008
TYSY_YEASTCDC21genetic
27708008
GRPE_YEASTMGE1genetic
27708008
COPZ_YEASTRET3genetic
27708008
CET1_YEASTCET1genetic
27708008
IWS1_YEASTSPN1genetic
27708008
SEC23_YEASTSEC23genetic
27708008
H4_YEASTHHF1genetic
27708008
GBP2_YEASTGBP2genetic
27708008
THRC_YEASTTHR4genetic
27708008
SND1_YEASTYDR186Cgenetic
27708008
RT103_YEASTRTT103genetic
27708008
UBP6_YEASTUBP6genetic
27708008
MET10_YEASTMET10genetic
27708008
STB5_YEASTSTB5genetic
27708008
CTK1_YEASTCTK1genetic
27708008
GBLP_YEASTASC1genetic
27708008
RL9B_YEASTRPL9Bgenetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
LEE1_YEASTLEE1genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
DVL3_HUMANDVL3physical
27107014
DVL2_HUMANDVL2physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RL9A_YEAST

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Related Literatures of Post-Translational Modification

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