| UniProt ID | CDC7_YEAST | |
|---|---|---|
| UniProt AC | P06243 | |
| Protein Name | Cell division control protein 7 | |
| Gene Name | CDC7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 507 | |
| Subcellular Localization | ||
| Protein Description | Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.. | |
| Protein Sequence | MTSKTKNIDDIPPEIKEEMIQLYHDLPGIENEYKLIDKIGEGTFSSVYKAKDITGKITKKFASHFWNYGSNYVALKKIYVTSSPQRIYNELNLLYIMTGSSRVAPLCDAKRVRDQVIAVLPYYPHEEFRTFYRDLPIKGIKKYIWELLRALKFVHSKGIIHRDIKPTNFLFNLELGRGVLVDFGLAEAQMDYKSMISSQNDYDNYANTNHDGGYSMRNHEQFCPCIMRNQYSPNSHNQTPPMVTIQNGKVVHLNNVNGVDLTKGYPKNETRRIKRANRAGTRGFRAPEVLMKCGAQSTKIDIWSVGVILLSLLGRRFPMFQSLDDADSLLELCTIFGWKELRKCAALHGLGFEASGLIWDKPNGYSNGLKEFVYDLLNKECTIGTFPEYSVAFETFGFLQQELHDRMSIEPQLPDPKTNMDAVDAYELKKYQEEIWSDHYWCFQVLEQCFEMDPQKRSSAEDLLKTPFFNELNENTYLLDGESTDEDDVVSSSEADLLDKDVLLISE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Ubiquitination | GTFSSVYKAKDITGK CCCCEEEECHHCCCC | 46.97 | 23749301 | |
| 83 | Phosphorylation | KKIYVTSSPQRIYNE EEEEECCCHHHHHHH | 18.71 | 8382976 | |
| 197 | Phosphorylation | MDYKSMISSQNDYDN HCHHHHHCCCCCCCC | 19.75 | 27017623 | |
| 198 | Phosphorylation | DYKSMISSQNDYDNY CHHHHHCCCCCCCCC | 23.29 | 28889911 | |
| 232 | Phosphorylation | CIMRNQYSPNSHNQT CHHCCCCCCCCCCCC | 14.08 | 23749301 | |
| 235 | Phosphorylation | RNQYSPNSHNQTPPM CCCCCCCCCCCCCCE | 27.48 | 23749301 | |
| 239 | Phosphorylation | SPNSHNQTPPMVTIQ CCCCCCCCCCEEEEE | 34.38 | 23749301 | |
| 408 | Phosphorylation | QELHDRMSIEPQLPD HHHHHHHCCCCCCCC | 25.37 | 27214570 | |
| 426 | Phosphorylation | NMDAVDAYELKKYQE CCCCCHHHHHHHHHH | 19.82 | 27017623 | |
| 429 | Ubiquitination | AVDAYELKKYQEEIW CCHHHHHHHHHHHHH | 37.18 | 23749301 | |
| 459 | Phosphorylation | MDPQKRSSAEDLLKT CCHHHCCCHHHHHCC | 39.45 | 27214570 | |
| 483 | Phosphorylation | TYLLDGESTDEDDVV EEEECCCCCCHHCCC | 46.84 | 28889911 | |
| 484 | Phosphorylation | YLLDGESTDEDDVVS EEECCCCCCHHCCCC | 38.82 | 28889911 | |
| 491 | Phosphorylation | TDEDDVVSSSEADLL CCHHCCCCHHHHHHC | 28.17 | 21551504 | |
| 506 | Phosphorylation | DKDVLLISE------ CCCEEEEEC------ | 36.90 | 22890988 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDC7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198, AND MASSSPECTROMETRY. | |
