CHIF_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHIF_DROME
• UniProt AC: Q9NK54
• Protein Name: Protein chiffon
• Gene Name: chif
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1711
• Protein Description: May be involved in initiation of DNA replication; activation of the chorion gene origins. May have a role in eye and thoracic bristle development..
• Protein Sequence: MQPQSDKQSASRLATTTSHSTAAASATAATPPKVKVIKSKRPLCHFKFYLDICDHQLAKRIESDIKALGGHLEFFLSDDITHFVTDKPEVIGGTSGTPGTPSTPGTPTSHYQQNDGSARKPNQRQSRADAILSRVRRSTVGVVNSGNSTPTTSLKRSYTIWQTDYAQRFIKRIQTELKQYLEGKKEGGGGSTSASPHHIQLKKQYVKIESVKRNYRPYYHLIKQPDDWPKIDLSSEDGAFRLLTKSKTKDKEHSMTRKPLGSRTSQKDKQAAGEAKPLQHPSLQELKKQSAIPNSPRSNCREPIDSSEKQGGVCEICKLEYDILNIHLQSKDHELFAKNSDNFLALDTLIQSSADVNRFLEEEPVESELDMDVDESLSNEELQSPRQRPSPALREKSKRITKGKHSSEKFQGVAVASPQTPFPGAKKVQGNSPGSLSELQRQEHPTTAAATPTTNSGRRKTQNSGLSPPKRAMLPPSSIYKVVETREECATPPRGRGRPPNQVDSPSLIVKFQKIRQTELQRLNGEAENFMFPRTAVPTTRSSSELPTDVDRQTTSDVRGRYSISSASLDTSTSEAETKESSGLPTSIRKRAQAVGRRRKVGGAAAQDVFQRQLSTGSSSSNSNQQRFPSAPIQPEEGPQPQPKPQLKIKIKQEQLVATRKSSRTATAIVTAATASSHQQQQLRQTTCRKMANKLEDRMGELVKPKIKIKKEVIEEQKVKELEDLEEILDKELDEEVDSSCSSGSDEDYIAGSQRRITAAPRKSTDTREQRAARRLSRLTINRSAGELELTEVKTSPSKSRTKIQKPSSPTKNKVKQTKAVPPAIDLFFDCSKSERLREMQYTFESLPSGELWNRVFLRQDAGEENYYTYYGSTNYRKLPYEMGPIPMAKTLPAHSCALCREASEVKQDKGEQIKLEDQKPAPKKEVKKEEEVQSSSSSATYKNKKLHLLQRYQQEQEQLQQLEGNSLATAGAKCDSKASTPELLEREFASGSMGDRVQLIERVRSTSSSSCSNSQRSGITCRNKQLARIAELPPRKSPREHASTLALVSCIIRQRQDSQSKTNSEAEEPPPPVAAPKLKTPIKQEPVAPSSPRTTRSQAATPVEELRFATEISETVKRMRRGQNKYDHSPPAPVPTPATSSPVRSRRLTPAARNQSQIYSRRLEFATSQRESSASALLGKRKRRVNPSVAGTVRPTTQNLPGTGAYRGVRKLPSKKGLLEYEMETCALKALDQARQYCNPGFVAWQLDKYLELAGKEYDIEFDQISPEVESEGREERLVNTPQTPPPTDCFTSEFDLCDLIMGSAGSGDDDEDVSRGNPPGSGRRMSNLNLYASYYRKRKSLKSNRTGWPKAQRRRNAGGLGGSRALPDERINFQKMGLAELHPIKQEPMETEEEQTTTTTTTTTTSATRGNLLSKDDEDDEGGGNSPSGGSPADDKQNSREDAVMTPPATDVDEQAEPQADEMESLPDEDETMADSVDQQQDVEAEIEATDADVEEEEEEEDEDEDVFEDAYEEQDMGIQKTEPHEKRARIPSISVTTPPEDSSQGKKLLLTLHNGQRLQATSTPSTGQVQQHQRRTPQLNGSLGSCISPSEKLGDNSDIFTVSSDGLDTDLDLSNTQAGDSHEHCPHQTTPKRKFDISKYAPPNSGKAASSCAAEAATAAVKSLAISQFLKKETCASSSSMRNAWRRTQRRAISAACISAAPSARVPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
306	Phosphorylation	NCREPIDSSEKQGGV CCCCCCCCCHHCCCE	40.91	25749252
307	Phosphorylation	CREPIDSSEKQGGVC CCCCCCCCHHCCCEE	45.10	25749252
406	Phosphorylation	RITKGKHSSEKFQGV HHHCCCCCCHHCCCE	43.61	22817900
407	Phosphorylation	ITKGKHSSEKFQGVA HHCCCCCCHHCCCEE	44.52	22817900
417	Phosphorylation	FQGVAVASPQTPFPG CCCEEEECCCCCCCC	15.79	22817900
432	Phosphorylation	AKKVQGNSPGSLSEL CCCCCCCCCCCHHHH	37.15	22817900
435	Phosphorylation	VQGNSPGSLSELQRQ CCCCCCCCHHHHHHC	31.91	22817900
467	Phosphorylation	KTQNSGLSPPKRAML CCCCCCCCCCCCCCC	42.56	22817900
542	Phosphorylation	TAVPTTRSSSELPTD CCCCCCCCCCCCCCC	35.80	22817900
543	Phosphorylation	AVPTTRSSSELPTDV CCCCCCCCCCCCCCC	25.25	22817900
544	Phosphorylation	VPTTRSSSELPTDVD CCCCCCCCCCCCCCC	44.38	22817900
784	Phosphorylation	SRLTINRSAGELELT HHHEECCCCCEEEEE	35.82	22817900
1081	Phosphorylation	VAAPKLKTPIKQEPV CCCCCCCCCCCCCCC	40.45	25749252
1091	Phosphorylation	KQEPVAPSSPRTTRS CCCCCCCCCCCCCHH	43.14	25749252
1092	Phosphorylation	QEPVAPSSPRTTRSQ CCCCCCCCCCCCHHC	19.83	10477296
1098	Phosphorylation	SSPRTTRSQAATPVE CCCCCCHHCCCCCHH	23.29	25749252
1102	Phosphorylation	TTRSQAATPVEELRF CCHHCCCCCHHHHHH	30.77	25749252
1130	Phosphorylation	GQNKYDHSPPAPVPT CCCCCCCCCCCCCCC	29.67	25749252
1604	Phosphorylation	GDNSDIFTVSSDGLD CCCCCCEEEECCCCC	21.58	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHIF_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHIF_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHIF_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306; SER-307; SER-406;SER-407; SER-417; SER-432; SER-435; SER-467; SER-542; SER-543;SER-544; THR-1081; SER-1091 AND SER-1092, AND MASS SPECTROMETRY.
PubMed: 18327897