| UniProt ID | BFA1_YEAST | |
|---|---|---|
| UniProt AC | P47113 | |
| Protein Name | Mitotic check point protein BFA1 | |
| Gene Name | BFA1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 574 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, spindle pole. | |
| Protein Description | Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex.. | |
| Protein Sequence | MSIRPLTLNGLDEPETSFEELNTTLPRFQSHETLTLEENVPPLSTSTYIPPPSSVGTSDTGTVFSNSTSAFWSNKQADDDQDMEVDQDDEFLNDFQEFQNKKDDFDDAIKTNFHLRNGCRTGPFKNDIFAEEFDRKLSLEDKPRLKQPRSMMELKPKRKLSNSVTSRNLRSGNSVRFKKSMPNLALVNPAIREEEEDEEREREDQREFNYKIDNDTQDTILAKFSSDDEGDFLTGFEELEGEAIDETISSNDKESADHPRFLKKSSSSLPLKISPAQYDIVKHDELLTPGLHRRQRDWNTQQELDSFKEKRSVRHCSNQNVQLNGPAKIKTIKQQIDHNTPMKKGSMIYNPKTMKWEGNENVLSKFSDVDTANRKALLIKNKLQRDADSKKQKYSDLQHARATSRNQKVIGNMILDEQNLRWVSVSEEEADPFAGIPEINLPPVGKSMKKRSSSPFLRSKSQVNTPFVSNDNDGVYQSTAAQARLRKYHSMRTLNGTTETPEISSTFHLSSRALEKFYHEENRWCKKLASWFIPRDETIISVDEETIMDESTVNSKRKSYMYEIRNMVINSTKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MSIRPLTLNGLDEP -CCCCCCCCCCCCCC | 22.36 | 11733064 | |
| 17 | Phosphorylation | GLDEPETSFEELNTT CCCCCCCCHHHHHCC | 29.06 | 11733064 | |
| 24 | Phosphorylation | SFEELNTTLPRFQSH CHHHHHCCCCCCCCC | 33.42 | 11733064 | |
| 30 | Phosphorylation | TTLPRFQSHETLTLE CCCCCCCCCCEEEHH | 22.15 | 11733064 | |
| 35 | Phosphorylation | FQSHETLTLEENVPP CCCCCEEEHHCCCCC | 39.27 | 11733064 | |
| 47 | Phosphorylation | VPPLSTSTYIPPPSS CCCCCCCCCCCCCCC | 26.09 | 11733064 | |
| 54 | Phosphorylation | TYIPPPSSVGTSDTG CCCCCCCCCCCCCCC | 30.27 | 11733064 | |
| 62 | Phosphorylation | VGTSDTGTVFSNSTS CCCCCCCCEECCCCC | 22.07 | 11733064 | |
| 69 | Phosphorylation | TVFSNSTSAFWSNKQ CEECCCCCHHHCCCC | 22.68 | 11733064 | |
| 102 | Ubiquitination | FQEFQNKKDDFDDAI HHHHHHCCCCHHHHH | 70.81 | 23749301 | |
| 138 | Phosphorylation | EEFDRKLSLEDKPRL HHHHHHCCCCCCCCC | 32.52 | 24961812 | |
| 150 | Phosphorylation | PRLKQPRSMMELKPK CCCCCCCCHHHCCCC | 29.21 | 21440633 | |
| 161 | Phosphorylation | LKPKRKLSNSVTSRN CCCCCCCCCCCCCCC | 30.05 | 30377154 | |
| 180 | Phosphorylation | NSVRFKKSMPNLALV CCEEECCCCCCEEEC | 39.81 | 24930733 | |
| 216 | Phosphorylation | NYKIDNDTQDTILAK CEECCCCCCCEEEEC | 34.30 | 27214570 | |
| 219 | Phosphorylation | IDNDTQDTILAKFSS CCCCCCCEEEECCCC | 14.20 | 28889911 | |
| 265 | Phosphorylation | HPRFLKKSSSSLPLK CCCHHHHCCCCCCCE | 33.59 | 21440633 | |
| 266 | Phosphorylation | PRFLKKSSSSLPLKI CCHHHHCCCCCCCEE | 32.59 | 21126336 | |
| 267 | Phosphorylation | RFLKKSSSSLPLKIS CHHHHCCCCCCCEEC | 42.88 | 21440633 | |
| 274 | Phosphorylation | SSLPLKISPAQYDIV CCCCCEECHHHHCEE | 16.76 | 21551504 | |
| 317 | Phosphorylation | KRSVRHCSNQNVQLN HHHHHCCCCCCCCCC | 35.01 | 21440633 | |
| 328 | Acetylation | VQLNGPAKIKTIKQQ CCCCCCHHHHHHHHH | 48.12 | 23572591 | |
| 340 | Phosphorylation | KQQIDHNTPMKKGSM HHHCCCCCCCCCCCE | 22.72 | 25704821 | |
| 346 | Phosphorylation | NTPMKKGSMIYNPKT CCCCCCCCEEECCCC | 15.75 | 21440633 | |
| 364 | Phosphorylation | EGNENVLSKFSDVDT ECCHHHHHHCCCCCH | 27.63 | 15665377 | |
| 424 | Phosphorylation | EQNLRWVSVSEEEAD CCCCEEEECCHHHCC | 16.99 | 11733064 | |
| 447 | Phosphorylation | NLPPVGKSMKKRSSS CCCCCCHHHCCCCCC | 29.88 | 11733064 | |
| 452 | Phosphorylation | GKSMKKRSSSPFLRS CHHHCCCCCCCCCCC | 44.01 | 25704821 | |
| 453 | Phosphorylation | KSMKKRSSSPFLRSK HHHCCCCCCCCCCCC | 46.17 | 21440633 | |
| 454 | Phosphorylation | SMKKRSSSPFLRSKS HHCCCCCCCCCCCCC | 22.40 | 21440633 | |
| 459 | Phosphorylation | SSSPFLRSKSQVNTP CCCCCCCCCCCCCCC | 38.51 | 21440633 | |
| 461 | Phosphorylation | SPFLRSKSQVNTPFV CCCCCCCCCCCCCCC | 40.38 | 21440633 | |
| 497 | Phosphorylation | SMRTLNGTTETPEIS CCCCCCCCCCCCCHH | 22.01 | 27017623 | |
| 498 | Phosphorylation | MRTLNGTTETPEISS CCCCCCCCCCCCHHH | 38.98 | 28889911 | |
| 500 | Phosphorylation | TLNGTTETPEISSTF CCCCCCCCCCHHHHH | 24.91 | 28889911 | |
| 506 | Phosphorylation | ETPEISSTFHLSSRA CCCCHHHHHCCCHHH | 14.32 | 27017623 | |
| 510 | Phosphorylation | ISSTFHLSSRALEKF HHHHHCCCHHHHHHH | 14.81 | 27017623 | |
| 511 | Phosphorylation | SSTFHLSSRALEKFY HHHHCCCHHHHHHHH | 28.12 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BFA1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BFA1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BFA1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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