IBD2_YEAST - dbPTM
IBD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IBD2_YEAST
UniProt AC P53892
Protein Name Protein IBD2
Gene Name IBD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 351
Subcellular Localization Cytoplasm, cytoskeleton, spindle pole .
Protein Description Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the G-protein TEM1 by the BFA1/BUB2 complex..
Protein Sequence MTPTNQSSGTTNASVEVLSEDGPMPINVMMQEGVKALTKILSNQLQDRQAFQNAPHAMQFVIRNGGKALSNARLEELKDALPKMDSLSLEDELAKIDGQSAYHIDSAEEKETFESKIGQIASRNSADFIIEEDLQNILDDDLKDSELNLDGEEAEIIFDYESQELDTPDGIGEKISQMIESVLPGGFGSEEQGGLRTVTNVEDLDVAEEVTDIDHDTVDAARLHGDGQHSISSRKHSRSKNSKKNGHVRRHDFYDESRDHKSCCPHHHYENLSKLRNYYYHDFEYISRTENRVPDFSVLVNESSPMCLFCEYYMVFGEPPRNMIKWYNRTFGYNRMPNPPRDEQDSRKRNR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTPTNQSSG
------CCCCCCCCC		38.5330377154
4Phosphorylation----MTPTNQSSGTT
----CCCCCCCCCCC		36.4030377154
7Phosphorylation-MTPTNQSSGTTNAS
-CCCCCCCCCCCCCE		32.5730377154
38PhosphorylationQEGVKALTKILSNQL
HHHHHHHHHHHHHHH		22.3930377154
42PhosphorylationKALTKILSNQLQDRQ
HHHHHHHHHHHHHHH		26.4628152593
70PhosphorylationRNGGKALSNARLEEL
CCCCCHHHHHCHHHH		33.0521440633
86PhosphorylationDALPKMDSLSLEDEL
HHHHHCCCCCHHHHH		19.1630377154
88PhosphorylationLPKMDSLSLEDELAK
HHHCCCCCHHHHHHH		33.3930377154
100PhosphorylationLAKIDGQSAYHIDSA
HHHHCCCCEEECCCH		36.0022890988
102PhosphorylationKIDGQSAYHIDSAEE
HHCCCCEEECCCHHH		12.4522890988
106PhosphorylationQSAYHIDSAEEKETF
CCEEECCCHHHHHHH		36.6622369663
112PhosphorylationDSAEEKETFESKIGQ
CCHHHHHHHHHHHHH		43.7119779198
115PhosphorylationEEKETFESKIGQIAS
HHHHHHHHHHHHHHH		25.9428889911
125PhosphorylationGQIASRNSADFIIEE
HHHHHCCCCCEEEHH		28.2728889911
211PhosphorylationLDVAEEVTDIDHDTV
CCHHHEECCCCCCHH		30.4322369663
217PhosphorylationVTDIDHDTVDAARLH
ECCCCCCHHHHHHHC		19.5022369663
230PhosphorylationLHGDGQHSISSRKHS
HCCCCCCCCCCCCCC		19.1128889911
232PhosphorylationGDGQHSISSRKHSRS
CCCCCCCCCCCCCCC		27.4028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IBD2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IBD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IBD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAD2_YEASTMAD2genetic
12072457
PPR1_YEASTPPR1physical
16554755
BFA1_YEASTBFA1genetic
12072457
BUB2_YEASTBUB2genetic
12072457
DYHC_YEASTDYN1genetic
12072457
PRP6_YEASTPRP6genetic
27708008
CDC37_YEASTCDC37genetic
27708008
RRP45_YEASTRRP45genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
SMD1_YEASTSMD1genetic
27708008
RRP4_YEASTRRP4genetic
27708008
MET30_YEASTMET30genetic
27708008
SPC3_YEASTSPC3genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TPT1_YEASTTPT1genetic
27708008
PRS10_YEASTRPT4genetic
27708008
TIM50_YEASTTIM50genetic
27708008
KPYK1_YEASTCDC19genetic
27708008
CDC24_YEASTCDC24genetic
27708008
LSM2_YEASTLSM2genetic
27708008
STU1_YEASTSTU1genetic
27708008
CDC27_YEASTCDC27genetic
27708008
ORC2_YEASTORC2genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
SEC18_YEASTSEC18genetic
27708008
CDK1_YEASTCDC28genetic
27708008
TAF5_YEASTTAF5genetic
27708008
AME1_YEASTAME1genetic
27708008
CDC10_YEASTCDC10genetic
27708008
PRP9_YEASTPRP9genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
TCPD_YEASTCCT4genetic
27708008
YRB1_YEASTYRB1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
STN1_YEASTSTN1genetic
27708008
SEC1_YEASTSEC1genetic
27708008
UTP5_YEASTUTP5genetic
27708008
RMRP_YEASTSNM1genetic
27708008
SMT3_YEASTSMT3genetic
27708008
TSC11_YEASTTSC11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CAK1_YEASTCAK1genetic
27708008
CDC14_YEASTCDC14genetic
27708008
ERG26_YEASTERG26genetic
27708008
SP105_YEASTSPC105genetic
27708008
CDC20_YEASTCDC20genetic
27708008
GPI10_YEASTGPI10genetic
27708008
SYYC_YEASTTYS1genetic
27708008
CWC22_YEASTCWC22genetic
27708008
YHI0_YEASTYHR020Wgenetic
27708008
MPPA_YEASTMAS2genetic
27708008
BRL1_YEASTBRL1genetic
27708008
ORC6_YEASTORC6genetic
27708008
DNA2_YEASTDNA2genetic
27708008
RPC9_YEASTRPC17genetic
27708008
PRP21_YEASTPRP21genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
ESS1_YEASTESS1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
FNTA_YEASTRAM2genetic
27708008
ASK1_YEASTASK1genetic
27708008
PRP19_YEASTPRP19genetic
27708008
NEP1_YEASTEMG1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
IMB1_YEASTKAP95genetic
27708008
SMC6_YEASTSMC6genetic
27708008
SEC39_YEASTSEC39genetic
27708008
TAF11_YEASTTAF11genetic
27708008
HMCS_YEASTERG13genetic
27708008
RNA14_YEASTRNA14genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
RPC6_YEASTRPC34genetic
27708008
MED4_YEASTMED4genetic
27708008
ESA1_YEASTESA1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
COPZ_YEASTRET3genetic
27708008
SEC62_YEASTSEC62genetic
27708008
NSL1_YEASTNSL1genetic
27708008
SRP54_YEASTSRP54genetic
27708008
RDS3_YEASTRDS3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IBD2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; TYR-102; SER-106;THR-211 AND SER-230, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.

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