| UniProt ID | DYHC_YEAST | |
|---|---|---|
| UniProt AC | P36022 | |
| Protein Name | Dynein heavy chain, cytoplasmic | |
| Gene Name | DYN1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 4092 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Concentrates at motile dots in the cytoplasm corresponding to the plus ends of cytoplasmic microtubules. | |
| Protein Description | Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.. | |
| Protein Sequence | MCKNEARLANELIEFVAATVTGIKNSPKENEQAFIDYLHCQYLERFQFFLGLLDGREFDTLFVFLFEELDRTIVTIDIGEEAIYDANLANKKYSTLLIIKSRSVIVDAEPIATQISAIYLPGPVNAGNLASIITHGVSSVFGQLIKSDTKTYSVETIDKTRRKLDDISKQFQQLHTSIETPDLLAMVPSIIKLAVSKGATSHDYANYLPSNDLESMRFLNILQSIANKWFLVLKQTLAIDRDIKNGSFLDEVEFWSNFYEVLKSLIEQTQSQEFQVCLSVLTNAKRFHNLTNLLNEGSLSDKFKLADKYNQFLSSIPIDEVRQASNLEDLQELFPVLASSLKKFRYSGYPVQRFVVLMDKISQEVMDAILSNLSDLFQLEYGSFLGLYEKSAGMIEEWDDIVQDVNLLIREDLRKRAPQELLIQKLTFTSASVKATLDEILSTRKRFFSLAETIKSISPSTYHEEIQRLYHPFEQIHDISVNFRLKLEQAESEFSKNMLDLEKKLQNTLASFMDSDHCPTEKLSYLVKFKPLMELCPRIKVKVLENQQILLLEIKKDIRQLETGLELLPKILHVEALNNIPPISARISYFLNVQSRIDNIVQYLEALFGSNWNDTLEGRSISTSIVQLRKETNPHDVFLHWLGNFPEKATANLLTTPILKLIRNNEDDYELKVNFDFALAAAYSELRSLTYMAFQVPSHIVRIARTYMYLYPRAINLVELIQTFFSLSKSLSYTFYTNIFLKRNVQTVWLLLQQILITPWESLQEESSEMSCSVHSLARLEKSIDGILSDYQILKNSEPQFAKEFSGLKSFDGTADDLHEVEEIISNIQAIFENLFTKGLTNVSDHISTFNNLIISIILEKVRLNLKKMHFPKHVLKLSFNEGRITSSPSLAAMKRSLLKDIEALLNKVVLINFLHDPDHPLSTTLTFNSLVIKLKDDIQNCIEQVQNLHCKINSYVKEWQKMEFLWQITEEAFLEVVDNSTQRCFGILKGLLDSQSKFDLIISRNNFSKNLVLHTEDAQRHIRSKMDSWILYVSKHLLTIYERDARKLHEDMNRDREAVEDMDINFTSLKNITVIIEAVNVNKRHLTERDIQIKLLGSVMRALTKLKVRFPSHFVYIDQLDNDFSSLRQSLSYVEQELQKHRVVIAKSLEEGVENINNLSQSLNESWSVRKPISPTLTPPEALKILEFFNESITKLKKKMHSVAAAAKMLLIPVVLNDQLTHVVEEVKTYDLVWRSIKNLWEDVQRTFETPWCRVDVLLLQSDLANFLRRADELPRAVKQFEMYKSLFSQVNMLTSVNKILVELKDGALKPRHWNMIFRDIGKRQIQKNLLDKLEFSLKDVMVLNLTLNEILLTKIIERAQKEFVIEKSLNRIKKFWKEAQYEVIEHSSGLKLVREWDVLEQACKEDLEELVSMKASNYYKIFEQDCLDLESKLTKLSEIQVNWVEVQFYWLDLYGILGENLDIQNFLPLETSKFKSLTSEYKMITTRAFQLDTTIEVIHIPNFDTTLKLTIDSLKMIKSSLSTFLERQRRQFPRFYFLGNDDLLKIIGSGKHHDQVSKFMKKMFGSIESIIFLEDFITGVRSVEGEVLNLNEKIELKDSIQAQEWLNILDTEIKLSVFTQFRDCLGQLKDGTDIEVVVSKYIFQAILLSAQVMWTELVEKCLQTNQFSKYWKEVDMKIKGLLDKLNKSSDNVKKKIEALLVEYLHFNNVIGQLKNCSTKEEARLLWAKVQKFYQKNDTLDDLNSVFISQSGYLLQYKFEYIGIPERLIYTPLLLIGFATLTDSLHQKYGGCFFGPAGTGKTETVKAFGQNLGRVVVVFNCDDSFDYQVLSRLLVGITQIGAWGCFDEFNRLDEKVLSAVSANIQQIQNGLQVGKSHITLLEEETPLSPHTAVFITLNPGYNGRSELPENLKKSFREFSMKSPQSGTIAEMILQIMGFEDSKSLASKIVHFLELLSSKCSSMNHYHFGLRTLKGVLRNCSPLISEFGEGEKTVVESLKRVILPSLGDTDELVFKDELSKIFDSAGTPLNSKAIVQCLKDAGQRSGFSMSEEFLKKCMQFYYMQKTQQALILVGKAGCGKTATWKTVIDAMAIFDGHANVVYVIDTKVLTKESLYGSMLKATLEWRDGLFTSILRRVNDDITGTFKNSRIWVVFDSDLDPEYVEAMNSVLDDNKILTLPNGERLPIPPNFRILFETDNLDHTTPATITRCGLLWFSTDVCSISSKIDHLLNKSYEALDNKLSMFELDKLKDLISDSFDMASLTNIFTCSNDLVHILGVRTFNKLETAVQLAVHLISSYRQWFQNLDDKSLKDVITLLIKRSLLYALAGDSTGESQRAFIQTINTYFGHDSQELSDYSTIVIANDKLSFSSFCSEIPSVSLEAHEVMRPDIVIPTIDTIKHEKIFYDLLNSKRGIILCGPPGSGKTMIMNNALRNSSLYDVVGINFSKDTTTEHILSALHRHTNYVTTSKGLTLLPKSDIKNLVLFCDEINLPKLDKYGSQNVVLFLRQLMEKQGFWKTPENKWVTIERIHIVGACNPPTDPGRIPMSERFTRHAAILYLGYPSGKSLSQIYEIYYKAIFKLVPEFRSYTEPFARASVHLYNECKARYSTGLQSHYLFSPRELTRLVRGVYTAINTGPRQTLRSLIRLWAYEAWRIFADRLVGVKEKNSFEQLLYETVDKYLPNQDLGNISSTSLLFSGLLSLDFKEVNKTDLVNFIEERFKTFCDEELEVPMVIHESMVDHILRIDRALKQVQGHMMLIGASRTGKTILTRFVAWLNGLKIVQPKIHRHSNLSDFDMILKKAISDCSLKESRTCLIIDESNILETAFLERMNTLLANADIPDLFQGEEYDKLLNNLRNKTRSLGLLLDTEQELYDWFVGEIAKNLHVVFTICDPTNNKSSAMISSPALFNRCIINWMGDWDTKTMSQVANNMVDVIPMEFTDFIVPEVNKELVFTEPIQTIRDAVVNILIHFDRNFYQKMKVGVNPRSPGYFIDGLRALVKLVTAKYQDLQENQRFVNVGLEKLNESVLKVNELNKTLSKKSTELTEKEKEARSTLDKMLMEQNESERKQEATEEIKKILKVQEEDIRKRKEVVMKSIQDIEPTILEAQRGVKNIKKQQLTEIRSMVNPPSGVKIVMEAVCAILGYQFSNWRDIQQFIRKDDFIHNIVHYDTTLHMKPQIRKYMEEEFLSDPNFTYETINRASKACGPLYQWVNAQINFSKVLENVDPLRQEMKRIEFESLKTKANLLAAEEMTQDLEASIEVSKRKYSLLIRDVEAIKTEMSNVQANLDRSISLVKSLTFEKERWLNTTKQFSKTSQELIGNCIISSIYETYFGHLNERERADMLVILKRLLGKFAVKYDVNYRFIDYLVTLDEKMKWLECGLDKNDYFLENMSIVMNSQDAVPFLLDPSSHMITVISNYYGNKTVLLSFLEEGFVKRLENAIRFGSVVIIQDGEFFDPIISRLISREFNHAGNRVTVEIGDHEVDVSGDFKLFIHSCDPSGDIPIFLRSRVRLVHFVTNKESIETRIFDITLTEENAEMQRKREDLIKLNTEYKLKLKNLEKRLLEELNNSQGNMLENDELMVTLNNLKKEAMNIEKKLSESEEFFPQFDNLVEEYSIIGKHSVKIFSMLEKFGQFHWFYGISIGQFLSCFKRVFIKKSRETRAARTRVDEILWLLYQEVYCQFSTALDKKFKMIMAMTMFCLYKFDIESEQYKEAVLTMIGVLSESSDGVPKLTVDTNNDLRYLWDYVTTKSYISALNWFKNEFFVDEWNIADVVANSENNYFTMASERDVDGTFKLIELAKASKESLKIIPLGSIENLNYAQEEISKSKIEGGWILLQNIQMSLSWVKTYLHKHVEETKAAEEHEKFKMFMTCHLTGDKLPAPLLQRTDRFVYEDIPGILDTVKDLWGSQFFTGKISGVWSVYCTFLLSWFHALITARTRLVPHGFSKKYYFNDCDFQFASVYLENVLATNSTNNIPWAQVRDHIATIVYGGKIDEEKDLEVVAKLCAHVFCGSDNLQIVPGVRIPQPLLQQSEEEERARLTAILSNTIEPADSLSSWLQLPRESILNYERLQAKEVASSTEQLLQEM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 72 | Phosphorylation | LFEELDRTIVTIDIG HHHCCCCEEEEEECC | 21.33 | 29688323 | |
| 75 | Phosphorylation | ELDRTIVTIDIGEEA CCCCEEEEEECCHHH | 14.74 | 29688323 | |
| 84 | Phosphorylation | DIGEEAIYDANLANK ECCHHHEEECCCCCC | 18.95 | 29688323 | |
| 362 | Phosphorylation | VVLMDKISQEVMDAI HHHHHHHCHHHHHHH | 26.48 | 20377248 | |
| 374 | Phosphorylation | DAILSNLSDLFQLEY HHHHHCHHHHHHHHH | 36.20 | 20377248 | |
| 620 | Phosphorylation | NDTLEGRSISTSIVQ CCCCCCCEECEEHHH | 31.57 | 28889911 | |
| 622 | Phosphorylation | TLEGRSISTSIVQLR CCCCCEECEEHHHHH | 19.83 | 19779198 | |
| 623 | Phosphorylation | LEGRSISTSIVQLRK CCCCEECEEHHHHHC | 22.32 | 28889911 | |
| 624 | Phosphorylation | EGRSISTSIVQLRKE CCCEECEEHHHHHCC | 17.61 | 28889911 | |
| 886 | Phosphorylation | SFNEGRITSSPSLAA EECCCCCCCCHHHHH | 23.07 | 19823750 | |
| 887 | Phosphorylation | FNEGRITSSPSLAAM ECCCCCCCCHHHHHH | 37.57 | 19823750 | |
| 888 | Phosphorylation | NEGRITSSPSLAAMK CCCCCCCCHHHHHHH | 15.17 | 19823750 | |
| 890 | Phosphorylation | GRITSSPSLAAMKRS CCCCCCHHHHHHHHH | 32.37 | 19795423 | |
| 1026 | Ubiquitination | AQRHIRSKMDSWILY HHHHHHHHHHHHHHH | 36.56 | 19722269 | |
| 1036 | Ubiquitination | SWILYVSKHLLTIYE HHHHHHHHHHHHHHH | 28.38 | 19722269 | |
| 1105 | Phosphorylation | GSVMRALTKLKVRFP HHHHHHHHHCCCCCC | 33.09 | 27017623 | |
| 1478 | Phosphorylation | LETSKFKSLTSEYKM CCCHHHHCCCHHHHE | 39.76 | 19795423 | |
| 1480 | Phosphorylation | TSKFKSLTSEYKMIT CHHHHCCCHHHHEEE | 26.97 | 19795423 | |
| 1481 | Phosphorylation | SKFKSLTSEYKMITT HHHHCCCHHHHEEEC | 44.19 | 19795423 | |
| 1483 | Phosphorylation | FKSLTSEYKMITTRA HHCCCHHHHEEECCE | 12.96 | 19795423 | |
| 1487 | Phosphorylation | TSEYKMITTRAFQLD CHHHHEEECCEEECC | 13.51 | 19795423 | |
| 1488 | Phosphorylation | SEYKMITTRAFQLDT HHHHEEECCEEECCC | 14.74 | 19795423 | |
| 1859 | Phosphorylation | RLDEKVLSAVSANIQ CCCHHHHHHHHHHHH | 29.61 | 28889911 | |
| 1862 | Phosphorylation | EKVLSAVSANIQQIQ HHHHHHHHHHHHHHH | 18.47 | 28889911 | |
| 1923 | Phosphorylation | FREFSMKSPQSGTIA HHHHHCCCCCCCCHH | 21.38 | 29136822 | |
| 1926 | Phosphorylation | FSMKSPQSGTIAEMI HHCCCCCCCCHHHHH | 41.09 | 29136822 | |
| 1928 | Phosphorylation | MKSPQSGTIAEMILQ CCCCCCCCHHHHHHH | 23.43 | 29136822 | |
| 1947 | Phosphorylation | EDSKSLASKIVHFLE CCCHHHHHHHHHHHH | 28.36 | 28889911 | |
| 1957 | Phosphorylation | VHFLELLSSKCSSMN HHHHHHHHHHCCCCC | 40.14 | 28889911 | |
| 2048 | Phosphorylation | AGQRSGFSMSEEFLK HHHCCCCCCCHHHHH | 25.56 | 27017623 | |
| 2086 | Phosphorylation | GKTATWKTVIDAMAI CCCCCHHHHHHHHHH | 17.79 | 27017623 | |
| 2102 | Phosphorylation | DGHANVVYVIDTKVL CCCCCEEEEEECCEE | 6.34 | 27017623 | |
| 2106 | Phosphorylation | NVVYVIDTKVLTKES CEEEEEECCEECCHH | 16.36 | 27017623 | |
| 2115 | Phosphorylation | VLTKESLYGSMLKAT EECCHHHHHHHHHHH | 19.21 | 19779198 | |
| 2117 | Phosphorylation | TKESLYGSMLKATLE CCHHHHHHHHHHHHH | 13.84 | 28889911 | |
| 2202 | Phosphorylation | ETDNLDHTTPATITR ECCCCCCCCCHHEEC | 33.86 | 28889911 | |
| 2206 | Phosphorylation | LDHTTPATITRCGLL CCCCCCHHEECCEEE | 24.88 | 28889911 | |
| 2208 | Phosphorylation | HTTPATITRCGLLWF CCCCHHEECCEEEEE | 18.62 | 28889911 | |
| 2330 | Phosphorylation | LYALAGDSTGESQRA HHHHHCCCCCHHHHH | 37.08 | 27017623 | |
| 2334 | Phosphorylation | AGDSTGESQRAFIQT HCCCCCHHHHHHHHH | 26.72 | 27017623 | |
| 3280 | Phosphorylation | RDVEAIKTEMSNVQA HHHHHHHHHHHHHHH | 30.70 | 27017623 | |
| 3294 | Phosphorylation | ANLDRSISLVKSLTF HHHHHHHHHHHHCHH | 28.49 | 27017623 | |
| 3951 | Phosphorylation | RLVPHGFSKKYYFND CCCCCCCCCCEECCC | 32.60 | 28889911 | |
| 3965 | Phosphorylation | DCDFQFASVYLENVL CCCCHHHHHHHHHHH | 16.75 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DYHC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DYHC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DYHC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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