| UniProt ID | KIN4_YEAST | |
|---|---|---|
| UniProt AC | Q01919 | |
| Protein Name | Serine/threonine-protein kinase KIN4 | |
| Gene Name | KIN4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 800 | |
| Subcellular Localization | ||
| Protein Description | This protein is probably a serine/threonine protein kinase.. | |
| Protein Sequence | MASVPKRHTYGGNVVTDRDRHSLQRNNEILHPIHKNQRKHATFGPYIIGSTLGEGEFGKVKLGWTKASSSNEVPKQVAIKLIRRDTIKKDADKEIKIYREINALKHLTHPNIIYLEEVLQNSKYIGIVLEFVSGGEFYKYIQRKRRLKESSACRLFAQLISGVNYMHYKGLVHRDLKLENLLLDKHENLVITDFGFVNEFFEDNELMKTSCGSPCYAAPELVVSTKAYEARKADVWSCGVILYAMLAGYLPWDDDHENPTGDDIARLYKYITQTPLKFPEYITPIPRDLLRRILVPNPRRRINLQTIKRHVWLKPHEAFLSIQPNYWDEHLQKERPKPPNKGDVGRHSTYSSSASSYSKSRDRNSLIIESTLEQHRMSPQLATSRPASPTFSTGSKVVLNDTKNDMKESNINGERTSASCRYTRDSKGNGQTQIEQVSARHSSRGNKHTSVAGLVTIPGSPTTARTRNAPSSKLTEHVKDSSQTSFTQEEFHRIGNYHVPRSRPRPTSYYPGLSRNTADNSLADIPVNKLGSNGRLTDAKDPVPLNAIHDTNKATISNNSIMLLSEGPAAKTSPVDYHYAIGDLNHGDKPITEVIDKINKDLTHKAAENGFPRESIDPESTSTILVTKEPTNSTDEDHVESQLENVGHSSNKSDASSDKDSKKIYEKKRFSFMSLYSSLNGSRSTVESRTSKGNAPPVSSRNPSGQSNRSNIKITQQQPRNLSDRVPNPDKKINDNRIRDNAPSYAESENPGRSVRASVMVSTLREENRSELSNEGNNVEAQTSTARKVLNFFKRRSMRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | ASVPKRHTYGGNVVT CCCCCCCCCCCCCCC | 28.09 | 28889911 | |
| 42 | Phosphorylation | KNQRKHATFGPYIIG CCCCCCCCCCCEEEE | 28.92 | 28889911 | |
| 51 | Phosphorylation | GPYIIGSTLGEGEFG CCEEEECCCCCCCCC | 33.30 | 28889911 | |
| 66 | Ubiquitination | KVKLGWTKASSSNEV EEEEEEEECCCCCCC | 39.50 | 23749301 | |
| 209 | Phosphorylation | EDNELMKTSCGSPCY CCCCHHCCCCCCCCC | 18.45 | 20855503 | |
| 210 | Phosphorylation | DNELMKTSCGSPCYA CCCHHCCCCCCCCCC | 15.80 | 22890988 | |
| 213 | Phosphorylation | LMKTSCGSPCYAAPE HHCCCCCCCCCCCCE | 19.00 | 22890988 | |
| 274 | Phosphorylation | LYKYITQTPLKFPEY HHHHHHCCCCCCCCC | 23.18 | 19779198 | |
| 348 | Phosphorylation | KGDVGRHSTYSSSAS CCCCCCCCCCCCCCC | 27.90 | 21440633 | |
| 349 | Phosphorylation | GDVGRHSTYSSSASS CCCCCCCCCCCCCCC | 22.69 | 21440633 | |
| 351 | Phosphorylation | VGRHSTYSSSASSYS CCCCCCCCCCCCCCC | 20.22 | 21551504 | |
| 352 | Phosphorylation | GRHSTYSSSASSYSK CCCCCCCCCCCCCCC | 21.36 | 21551504 | |
| 355 | Phosphorylation | STYSSSASSYSKSRD CCCCCCCCCCCCCCC | 31.58 | 21440633 | |
| 356 | Phosphorylation | TYSSSASSYSKSRDR CCCCCCCCCCCCCCC | 32.89 | 21551504 | |
| 358 | Phosphorylation | SSSASSYSKSRDRNS CCCCCCCCCCCCCCC | 26.55 | 21440633 | |
| 359 | Acetylation | SSASSYSKSRDRNSL CCCCCCCCCCCCCCE | 41.08 | 22865919 | |
| 360 | Phosphorylation | SASSYSKSRDRNSLI CCCCCCCCCCCCCEE | 33.21 | 28889911 | |
| 365 | Phosphorylation | SKSRDRNSLIIESTL CCCCCCCCEEEHHHH | 23.10 | 17330950 | |
| 370 | Phosphorylation | RNSLIIESTLEQHRM CCCEEEHHHHHHHCC | 28.08 | 24961812 | |
| 378 | Phosphorylation | TLEQHRMSPQLATSR HHHHHCCCHHHCCCC | 14.95 | 28889911 | |
| 383 | Phosphorylation | RMSPQLATSRPASPT CCCHHHCCCCCCCCC | 33.58 | 28152593 | |
| 384 | Phosphorylation | MSPQLATSRPASPTF CCHHHCCCCCCCCCC | 30.57 | 19684113 | |
| 388 | Phosphorylation | LATSRPASPTFSTGS HCCCCCCCCCCCCCC | 27.44 | 21082442 | |
| 390 | Phosphorylation | TSRPASPTFSTGSKV CCCCCCCCCCCCCEE | 27.94 | 23749301 | |
| 392 | Phosphorylation | RPASPTFSTGSKVVL CCCCCCCCCCCEEEE | 34.04 | 28889911 | |
| 393 | Phosphorylation | PASPTFSTGSKVVLN CCCCCCCCCCEEEEC | 41.08 | 19779198 | |
| 395 | Phosphorylation | SPTFSTGSKVVLNDT CCCCCCCCEEEECCC | 23.51 | 19779198 | |
| 403 | Ubiquitination | KVVLNDTKNDMKESN EEEECCCCCCCCCCC | 54.54 | 23749301 | |
| 407 | Ubiquitination | NDTKNDMKESNINGE CCCCCCCCCCCCCCC | 61.94 | 23749301 | |
| 427 | Ubiquitination | CRYTRDSKGNGQTQI EEECCCCCCCCCEEE | 61.76 | 23749301 | |
| 442 | Phosphorylation | EQVSARHSSRGNKHT EEEHHCCCCCCCCCC | 19.04 | 21440633 | |
| 447 | Acetylation | RHSSRGNKHTSVAGL CCCCCCCCCCEEEEE | 51.59 | 22865919 | |
| 449 | Phosphorylation | SSRGNKHTSVAGLVT CCCCCCCCEEEEEEE | 26.89 | 22369663 | |
| 450 | Phosphorylation | SRGNKHTSVAGLVTI CCCCCCCEEEEEEEC | 15.08 | 22369663 | |
| 456 | Phosphorylation | TSVAGLVTIPGSPTT CEEEEEEECCCCCCC | 26.88 | 28132839 | |
| 460 | Phosphorylation | GLVTIPGSPTTARTR EEEECCCCCCCCCCC | 17.45 | 22369663 | |
| 462 | Phosphorylation | VTIPGSPTTARTRNA EECCCCCCCCCCCCC | 34.48 | 22369663 | |
| 463 | Phosphorylation | TIPGSPTTARTRNAP ECCCCCCCCCCCCCC | 19.95 | 22369663 | |
| 466 | Phosphorylation | GSPTTARTRNAPSSK CCCCCCCCCCCCCHH | 26.30 | 24961812 | |
| 471 | Phosphorylation | ARTRNAPSSKLTEHV CCCCCCCCHHHHHHH | 37.38 | 24961812 | |
| 472 | Phosphorylation | RTRNAPSSKLTEHVK CCCCCCCHHHHHHHC | 30.53 | 24961812 | |
| 481 | Phosphorylation | LTEHVKDSSQTSFTQ HHHHHCCCCCCCCCH | 20.73 | 28889911 | |
| 482 | Phosphorylation | TEHVKDSSQTSFTQE HHHHCCCCCCCCCHH | 47.84 | 23749301 | |
| 484 | Phosphorylation | HVKDSSQTSFTQEEF HHCCCCCCCCCHHHH | 27.96 | 23749301 | |
| 485 | Phosphorylation | VKDSSQTSFTQEEFH HCCCCCCCCCHHHHH | 20.75 | 23749301 | |
| 487 | Phosphorylation | DSSQTSFTQEEFHRI CCCCCCCCHHHHHHH | 34.53 | 28889911 | |
| 508 | Phosphorylation | RSRPRPTSYYPGLSR CCCCCCCCCCCCCCC | 25.92 | 23749301 | |
| 521 | Phosphorylation | SRNTADNSLADIPVN CCCCCCCCCCCCCCC | 26.02 | 23749301 | |
| 532 | Phosphorylation | IPVNKLGSNGRLTDA CCCCCCCCCCCCCCC | 46.69 | 22369663 | |
| 537 | Phosphorylation | LGSNGRLTDAKDPVP CCCCCCCCCCCCCCC | 32.33 | 22369663 | |
| 551 | Phosphorylation | PLNAIHDTNKATISN CCCCCCCCCCCEECC | 25.18 | 22369663 | |
| 557 | Phosphorylation | DTNKATISNNSIMLL CCCCCEECCCEEEEE | 26.13 | 21551504 | |
| 560 | Phosphorylation | KATISNNSIMLLSEG CCEECCCEEEEEECC | 17.39 | 28889911 | |
| 565 | Phosphorylation | NNSIMLLSEGPAAKT CCEEEEEECCCCCCC | 36.22 | 27017623 | |
| 572 | Phosphorylation | SEGPAAKTSPVDYHY ECCCCCCCCCCCEEE | 33.27 | 21440633 | |
| 573 | Phosphorylation | EGPAAKTSPVDYHYA CCCCCCCCCCCEEEE | 23.40 | 28889911 | |
| 577 | Phosphorylation | AKTSPVDYHYAIGDL CCCCCCCEEEECCCC | 9.28 | 19823750 | |
| 579 | Phosphorylation | TSPVDYHYAIGDLNH CCCCCEEEECCCCCC | 8.16 | 19823750 | |
| 615 | Phosphorylation | ENGFPRESIDPESTS HCCCCHHHCCCCCCC | 33.30 | 22369663 | |
| 620 | Phosphorylation | RESIDPESTSTILVT HHHCCCCCCCEEEEE | 32.80 | 22369663 | |
| 621 | Phosphorylation | ESIDPESTSTILVTK HHCCCCCCCEEEEEC | 28.38 | 22369663 | |
| 622 | Phosphorylation | SIDPESTSTILVTKE HCCCCCCCEEEEECC | 23.80 | 22369663 | |
| 623 | Phosphorylation | IDPESTSTILVTKEP CCCCCCCEEEEECCC | 20.58 | 22369663 | |
| 627 | Phosphorylation | STSTILVTKEPTNST CCCEEEEECCCCCCC | 26.67 | 22369663 | |
| 631 | Phosphorylation | ILVTKEPTNSTDEDH EEEECCCCCCCCHHH | 42.78 | 19795423 | |
| 633 | Phosphorylation | VTKEPTNSTDEDHVE EECCCCCCCCHHHHH | 39.45 | 19795423 | |
| 634 | Phosphorylation | TKEPTNSTDEDHVES ECCCCCCCCHHHHHH | 45.54 | 19795423 | |
| 641 | Phosphorylation | TDEDHVESQLENVGH CCHHHHHHHHHHCCC | 38.69 | 21551504 | |
| 649 | Phosphorylation | QLENVGHSSNKSDAS HHHHCCCCCCCCCCC | 29.67 | 19795423 | |
| 650 | Phosphorylation | LENVGHSSNKSDASS HHHCCCCCCCCCCCC | 42.47 | 19795423 | |
| 653 | Phosphorylation | VGHSSNKSDASSDKD CCCCCCCCCCCCCCH | 42.53 | 19823750 | |
| 656 | Phosphorylation | SSNKSDASSDKDSKK CCCCCCCCCCCHHHH | 44.02 | 19823750 | |
| 657 | Phosphorylation | SNKSDASSDKDSKKI CCCCCCCCCCHHHHH | 50.85 | 19823750 | |
| 661 | Phosphorylation | DASSDKDSKKIYEKK CCCCCCHHHHHHHHH | 41.40 | 19795423 | |
| 671 | Phosphorylation | IYEKKRFSFMSLYSS HHHHHCCCHHHHHHH | 24.87 | 28889911 | |
| 674 | Phosphorylation | KKRFSFMSLYSSLNG HHCCCHHHHHHHHCC | 23.34 | 28889911 | |
| 676 | Phosphorylation | RFSFMSLYSSLNGSR CCCHHHHHHHHCCCC | 6.73 | 28889911 | |
| 678 | Phosphorylation | SFMSLYSSLNGSRST CHHHHHHHHCCCCCC | 16.58 | 28889911 | |
| 682 | Phosphorylation | LYSSLNGSRSTVESR HHHHHCCCCCCCCCC | 23.22 | 21440633 | |
| 691 | Phosphorylation | STVESRTSKGNAPPV CCCCCCCCCCCCCCC | 37.14 | 17563356 | |
| 699 | Phosphorylation | KGNAPPVSSRNPSGQ CCCCCCCCCCCCCCC | 29.38 | 22369663 | |
| 700 | Phosphorylation | GNAPPVSSRNPSGQS CCCCCCCCCCCCCCC | 35.99 | 20377248 | |
| 704 | Phosphorylation | PVSSRNPSGQSNRSN CCCCCCCCCCCCCCC | 53.68 | 20377248 | |
| 707 | Phosphorylation | SRNPSGQSNRSNIKI CCCCCCCCCCCCCEE | 37.42 | 22369663 | |
| 710 | Phosphorylation | PSGQSNRSNIKITQQ CCCCCCCCCCEEEEC | 47.35 | 20377248 | |
| 723 | Phosphorylation | QQQPRNLSDRVPNPD ECCCCCHHHCCCCCC | 27.24 | 21440633 | |
| 744 | Phosphorylation | RIRDNAPSYAESENP CCCCCCCCHHHCCCC | 34.27 | 19684113 | |
| 745 | Phosphorylation | IRDNAPSYAESENPG CCCCCCCHHHCCCCC | 17.21 | 21440633 | |
| 748 | Phosphorylation | NAPSYAESENPGRSV CCCCHHHCCCCCHHH | 34.21 | 19684113 | |
| 758 | Phosphorylation | PGRSVRASVMVSTLR CCHHHHHHHHHHHCC | 10.53 | 27017623 | |
| 770 | Phosphorylation | TLREENRSELSNEGN HCCHHCHHHHCCCCC | 55.24 | 23749301 | |
| 773 | Phosphorylation | EENRSELSNEGNNVE HHCHHHHCCCCCCHH | 28.87 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KIN4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KIN4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KIN4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-388; THR-390;SER-620 AND SER-678, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, AND MASSSPECTROMETRY. | |
