| UniProt ID | FRK1_YEAST | |
|---|---|---|
| UniProt AC | Q03002 | |
| Protein Name | Fatty acyl-CoA synthetase and RNA processing-associated kinase 1 | |
| Gene Name | FRK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 865 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Putative serine/threonine-protein kinase that may be involved in rRNA transcription and ribosome biogenesis.. | |
| Protein Sequence | MSYTNKRHTYYGGFTNDLSDTFQYPQRTDEQRRKHVTFGPYILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRKEVKIYREINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQLISGVHYIHSKGLVHRDLKLENLLLDKNENLVITDFGFVNEFCSRNELMKTSCGSPCYAAPELVISAEPYEARKADIWSCGVILYAILAGYLPWDDDPNNPEGSDIGRLYNYINSTPLKFPDYILPIPRDLLRRMLVSDPKKRINLKQIKKHEWLKPHSSFLSITPDEWDKLNNTQSVFRLAKPRRRYGSRPQSSCSTSSLGSRSDKRDSLVIDSTLITFPAPPQESQNHIITRPASIASDQRLSPIRRSNRHNRSNSAASVALQAVVNADREYVLSHEQSLSPVQNIRQTTGNMTASLSPPPAISPGDIIIETTPIKRNTISGSSIVPSLEEESSTTMQTSKIQPNNMASSQNHQYNKNKTQNSLQSAKNFYRTSSSSHTKPRPTSYHPGSYTTPPYNSNTLSIYEINEKAKSSASSQTLNQRDTSPFDSTPYLALDTCITSSSSIESSPKLITHGQFSVAKPSVDLQSVSGDLIKYKRDADVVTRIYDEKYKQKRKSLRYSGIFSDISCDTVTEESDELRPPESPLQQHEGQESIDKAKTEDTSEKGSKSSNIAKATAQKHVNNHLERSLNEAESTKKRFSFLSLYSYDTSKSSLYSSMDSKRKPSPPSQRRPKKDDSYQTNSKNHYITASNMQTSHQVSKDLPAPTMVQNKCTLETKKAVRSNRSSIMVSEVNKASVDNKAAQSPEHSTAKRVLGFFKRRSMKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | SYTNKRHTYYGGFTN CCCCCCCCEECCCCC | 23.59 | 30377154 | |
| 10 | Phosphorylation | YTNKRHTYYGGFTND CCCCCCCEECCCCCC | 8.25 | 30377154 | |
| 11 | Phosphorylation | TNKRHTYYGGFTNDL CCCCCCEECCCCCCC | 16.36 | 30377154 | |
| 19 | Phosphorylation | GGFTNDLSDTFQYPQ CCCCCCCHHHCCCCC | 37.15 | 30377154 | |
| 21 | Phosphorylation | FTNDLSDTFQYPQRT CCCCCHHHCCCCCCC | 14.84 | 30377154 | |
| 24 | Phosphorylation | DLSDTFQYPQRTDEQ CCHHHCCCCCCCHHH | 9.35 | 30377154 | |
| 64 | Phosphorylation | LGWPKNFSNSSNSTF ECCCCCCCCCCCCCC | 45.24 | 21440633 | |
| 66 | Phosphorylation | WPKNFSNSSNSTFDF CCCCCCCCCCCCCCC | 29.69 | 22369663 | |
| 67 | Phosphorylation | PKNFSNSSNSTFDFP CCCCCCCCCCCCCCC | 38.76 | 22369663 | |
| 69 | Phosphorylation | NFSNSSNSTFDFPKQ CCCCCCCCCCCCCHH | 32.19 | 20377248 | |
| 70 | Phosphorylation | FSNSSNSTFDFPKQV CCCCCCCCCCCCHHH | 31.32 | 21440633 | |
| 209 | Phosphorylation | SRNELMKTSCGSPCY CCCHHHHCCCCCCCC | 18.45 | 30377154 | |
| 210 | Phosphorylation | RNELMKTSCGSPCYA CCHHHHCCCCCCCCC | 15.80 | 30377154 | |
| 213 | Phosphorylation | LMKTSCGSPCYAAPE HHHCCCCCCCCCCCE | 19.00 | 28889911 | |
| 216 | Phosphorylation | TSCGSPCYAAPELVI CCCCCCCCCCCEEEE | 14.80 | 27017623 | |
| 224 | Phosphorylation | AAPELVISAEPYEAR CCCEEEEECCCCHHH | 21.07 | 30377154 | |
| 228 | Phosphorylation | LVISAEPYEARKADI EEEECCCCHHHHHHH | 17.46 | 30377154 | |
| 335 | Phosphorylation | DKLNNTQSVFRLAKP HHHCCCHHHHHHCCC | 22.61 | 21551504 | |
| 348 | Phosphorylation | KPRRRYGSRPQSSCS CCCCCCCCCCCCCCC | 31.67 | 23749301 | |
| 352 | Phosphorylation | RYGSRPQSSCSTSSL CCCCCCCCCCCCCCC | 35.67 | 23749301 | |
| 357 | Phosphorylation | PQSSCSTSSLGSRSD CCCCCCCCCCCCCCC | 13.79 | 23749301 | |
| 358 | Phosphorylation | QSSCSTSSLGSRSDK CCCCCCCCCCCCCCC | 36.52 | 21440633 | |
| 361 | Phosphorylation | CSTSSLGSRSDKRDS CCCCCCCCCCCCCCC | 33.63 | 23749301 | |
| 395 | Phosphorylation | HIITRPASIASDQRL CCCCCCCHHCCCCCC | 22.75 | 30377154 | |
| 398 | Phosphorylation | TRPASIASDQRLSPI CCCCHHCCCCCCCCC | 32.38 | 30377154 | |
| 414 | Phosphorylation | RSNRHNRSNSAASVA CCCCCCCCCCHHHHH | 40.22 | 28889911 | |
| 416 | Phosphorylation | NRHNRSNSAASVALQ CCCCCCCCHHHHHHH | 26.85 | 28889911 | |
| 419 | Phosphorylation | NRSNSAASVALQAVV CCCCCHHHHHHHHHH | 13.98 | 28889911 | |
| 435 | Phosphorylation | ADREYVLSHEQSLSP CCHHHHHCCCCCCCC | 18.22 | 30377154 | |
| 439 | Phosphorylation | YVLSHEQSLSPVQNI HHHCCCCCCCCCCCH | 28.03 | 25704821 | |
| 441 | Phosphorylation | LSHEQSLSPVQNIRQ HCCCCCCCCCCCHHH | 28.42 | 25704821 | |
| 458 | Phosphorylation | GNMTASLSPPPAISP CCCEECCCCCCCCCC | 32.63 | 19779198 | |
| 472 | Phosphorylation | PGDIIIETTPIKRNT CCCEEEECCCCCCCC | 27.71 | 19779198 | |
| 479 | Phosphorylation | TTPIKRNTISGSSIV CCCCCCCCCCCCCCC | 22.13 | 30377154 | |
| 481 | Phosphorylation | PIKRNTISGSSIVPS CCCCCCCCCCCCCCC | 30.50 | 30377154 | |
| 483 | Phosphorylation | KRNTISGSSIVPSLE CCCCCCCCCCCCCCC | 15.31 | 30377154 | |
| 484 | Phosphorylation | RNTISGSSIVPSLEE CCCCCCCCCCCCCCC | 31.00 | 30377154 | |
| 488 | Phosphorylation | SGSSIVPSLEEESST CCCCCCCCCCCCCCC | 37.20 | 30377154 | |
| 493 | Phosphorylation | VPSLEEESSTTMQTS CCCCCCCCCCCCCCC | 35.94 | 30377154 | |
| 494 | Phosphorylation | PSLEEESSTTMQTSK CCCCCCCCCCCCCCC | 31.04 | 30377154 | |
| 496 | Phosphorylation | LEEESSTTMQTSKIQ CCCCCCCCCCCCCCC | 14.83 | 30377154 | |
| 499 | Phosphorylation | ESSTTMQTSKIQPNN CCCCCCCCCCCCCCC | 22.59 | 30377154 | |
| 500 | Phosphorylation | SSTTMQTSKIQPNNM CCCCCCCCCCCCCCC | 15.74 | 30377154 | |
| 544 | Phosphorylation | SHTKPRPTSYHPGSY CCCCCCCCCCCCCCC | 43.10 | 21551504 | |
| 545 | Phosphorylation | HTKPRPTSYHPGSYT CCCCCCCCCCCCCCC | 24.91 | 27017623 | |
| 558 | Phosphorylation | YTTPPYNSNTLSIYE CCCCCCCCCEEEEEE | 25.91 | 21551504 | |
| 560 | Phosphorylation | TPPYNSNTLSIYEIN CCCCCCCEEEEEEEC | 23.00 | 27017623 | |
| 572 | Phosphorylation | EINEKAKSSASSQTL EECHHHHHCCCCCCC | 35.68 | 23749301 | |
| 573 | Phosphorylation | INEKAKSSASSQTLN ECHHHHHCCCCCCCC | 31.31 | 28889911 | |
| 575 | Phosphorylation | EKAKSSASSQTLNQR HHHHHCCCCCCCCCC | 25.56 | 19684113 | |
| 576 | Phosphorylation | KAKSSASSQTLNQRD HHHHCCCCCCCCCCC | 27.22 | 23749301 | |
| 578 | Phosphorylation | KSSASSQTLNQRDTS HHCCCCCCCCCCCCC | 29.62 | 19684113 | |
| 623 | Phosphorylation | QFSVAKPSVDLQSVS CCEECCCCCCHHHCC | 27.79 | 28889911 | |
| 628 | Phosphorylation | KPSVDLQSVSGDLIK CCCCCHHHCCCCHHH | 26.08 | 24961812 | |
| 630 | Phosphorylation | SVDLQSVSGDLIKYK CCCHHHCCCCHHHEE | 31.66 | 24961812 | |
| 668 | Phosphorylation | SGIFSDISCDTVTEE CCCCCCCCCCCCCCC | 15.78 | 27017623 | |
| 673 | Phosphorylation | DISCDTVTEESDELR CCCCCCCCCCCCCCC | 35.81 | 27017623 | |
| 676 | Phosphorylation | CDTVTEESDELRPPE CCCCCCCCCCCCCCC | 30.10 | 27017623 | |
| 729 | Phosphorylation | VNNHLERSLNEAEST HHHHHHHHHHHHHHH | 26.60 | 24961812 | |
| 735 | Phosphorylation | RSLNEAESTKKRFSF HHHHHHHHHHHHEEE | 53.20 | 24961812 | |
| 736 | Phosphorylation | SLNEAESTKKRFSFL HHHHHHHHHHHEEEE | 31.90 | 24961812 | |
| 741 | Phosphorylation | ESTKKRFSFLSLYSY HHHHHHEEEEEEEEE | 29.34 | 21440633 | |
| 744 | Phosphorylation | KKRFSFLSLYSYDTS HHHEEEEEEEEECCC | 24.21 | 24961812 | |
| 746 | Phosphorylation | RFSFLSLYSYDTSKS HEEEEEEEEECCCHH | 11.21 | 24961812 | |
| 747 | Phosphorylation | FSFLSLYSYDTSKSS EEEEEEEEECCCHHH | 23.09 | 24961812 | |
| 748 | Phosphorylation | SFLSLYSYDTSKSSL EEEEEEEECCCHHHH | 15.08 | 24961812 | |
| 750 | Phosphorylation | LSLYSYDTSKSSLYS EEEEEECCCHHHHHH | 29.80 | 24961812 | |
| 751 | Phosphorylation | SLYSYDTSKSSLYSS EEEEECCCHHHHHHC | 27.87 | 24961812 | |
| 766 | Phosphorylation | MDSKRKPSPPSQRRP CCCCCCCCCCCCCCC | 53.10 | 23749301 | |
| 778 | Phosphorylation | RRPKKDDSYQTNSKN CCCCCCCCCCCCCCC | 29.31 | 27017623 | |
| 817 | Phosphorylation | QNKCTLETKKAVRSN ECCCCHHHHHHHHCC | 40.74 | 27017623 | |
| 823 | Phosphorylation | ETKKAVRSNRSSIMV HHHHHHHCCCCCEEE | 29.96 | 21440633 | |
| 826 | Phosphorylation | KAVRSNRSSIMVSEV HHHHCCCCCEEEEEC | 28.59 | 29136822 | |
| 827 | Phosphorylation | AVRSNRSSIMVSEVN HHHCCCCCEEEEECC | 16.09 | 29136822 | |
| 831 | Phosphorylation | NRSSIMVSEVNKASV CCCCEEEEECCHHHH | 20.60 | 29136822 | |
| 845 | Phosphorylation | VDNKAAQSPEHSTAK HCCCHHCCCCCHHHH | 27.77 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FRK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FRK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FRK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67 AND SER-213, AND MASSSPECTROMETRY. | |
