RAD2_YEAST - dbPTM
RAD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD2_YEAST
UniProt AC P07276
Protein Name DNA repair protein RAD2
Gene Name RAD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1031
Subcellular Localization Nucleus.
Protein Description Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair..
Protein Sequence MGVHSFWDIAGPTARPVRLESLEDKRMAVDASIWIYQFLKAVRDQEGNAVKNSHITGFFRRICKLLYFGIRPVFVFDGGVPVLKRETIRQRKERRQGKRESAKSTARKLLALQLQNGSNDNVKNSTPSSGSSVQIFKPQDEWDLPDIPGFKYDKEDARVNSNKTFEKLMNSINGDGLEDIDLDTINPASAEFEELPKATQYLILSSLRLKSRLRMGYSKEQLETIFPNSMDFSRFQIDMVKRRNFFTQKLINTTGFQDGGASKLNEEVINRISGQKSKEYKLTKTNNGWILGLGANDGSDAQKAIVIDDKDAGALVKQLDSNAEDGDVLRWDDLEDNSLKIVRHESSNATTAPQKRSNRSEDEGCDSDECEWEEVELKPKNVKFVEDFSLKAARLPYMGQSLNNAGSKSFLDKRHDQASPSKTTPTMRISRISVEDDDEDYLKQIEEIEMMEAVQLSKMEKKPEADDKSKIAKPVTSKGTEARPPIVQYGLLGAQPDSKQPYHVTNLNSKSESVIKRTSKTVLSEFRPPSQQEDKGAILTEGEQNLNFISHKIPQFDFNNENSLLFQKNTESNVSQEATKEKSPIPEMPSWFSSTASQQLYNPYNTTNFVEDKNVRNEQESGAETTNKGSSYELLTGLNATEILERESEKESSNDENKDDDLEVLSEELFEDVPTKSQISKEAEDNDSRKVESINKEHRKPLIFDYDFSEDEEDNIVENMIKEQEEFDTFKNTTLSTSAERNVAENAFVEDELFEQQMKDKRDSDEVTMDMIKEVQELLSRFGIPYITAPMEAEAQCAELLQLNLVDGIITDDSDVFLFGGTKIYKNMFHEKNYVEFYDAESILKLLGLDRKNMIELAQLLGSDYTNGLKGMGPVSSIEVIAEFGNLKNFKDWYNNGQFDKRKQETENKFEKDLRKKLVNNEIILDDDFPSVMVYDAYMRPEVDHDTTPFVWGVPDLDMLRSFMKTQLGWPHEKSDEILIPLIRDVNKRKKKGKQKRINEFFPREYISGDKKLNTSKRISTATGKLKKRKM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
118PhosphorylationALQLQNGSNDNVKNS
HHHHHCCCCCCCCCC		48.8622369663
129PhosphorylationVKNSTPSSGSSVQIF
CCCCCCCCCCCEEEE		43.8521440633
161PhosphorylationKEDARVNSNKTFEKL
HHHCCCCCHHHHHHH		36.5324930733
164PhosphorylationARVNSNKTFEKLMNS
CCCCCHHHHHHHHHH		41.0823749301
321PhosphorylationALVKQLDSNAEDGDV
HHHHHHHCCCCCCCC		46.6725752575
346PhosphorylationLKIVRHESSNATTAP
EEEEEECCCCCCCCC		23.8321440633
347PhosphorylationKIVRHESSNATTAPQ
EEEEECCCCCCCCCC		27.7428889911
350PhosphorylationRHESSNATTAPQKRS
EECCCCCCCCCCCCC		27.9530377154
357PhosphorylationTTAPQKRSNRSEDEG
CCCCCCCCCCCCCCC		43.5621440633
360PhosphorylationPQKRSNRSEDEGCDS
CCCCCCCCCCCCCCC		54.3619684113
367PhosphorylationSEDEGCDSDECEWEE
CCCCCCCCCCCCEEE		39.1125704821
419PhosphorylationDKRHDQASPSKTTPT
HHCCCCCCCCCCCCC		24.8728889911
421PhosphorylationRHDQASPSKTTPTMR
CCCCCCCCCCCCCEE		39.8927717283
502PhosphorylationQPDSKQPYHVTNLNS
CCCCCCCCEEECCCC		13.3628889911
509PhosphorylationYHVTNLNSKSESVIK
CEEECCCCCCHHHHH		40.5028889911
524PhosphorylationRTSKTVLSEFRPPSQ
HCCCHHHHHCCCCCC		30.2824961812
530PhosphorylationLSEFRPPSQQEDKGA
HHHCCCCCCCCCCCE		47.3724961812
572PhosphorylationLFQKNTESNVSQEAT
EEECCCCCCCCHHHH		40.2630377154
575PhosphorylationKNTESNVSQEATKEK
CCCCCCCCHHHHCCC		26.9325752575
579PhosphorylationSNVSQEATKEKSPIP
CCCCHHHHCCCCCCC		38.7030377154
583PhosphorylationQEATKEKSPIPEMPS
HHHHCCCCCCCCCCC		29.2021440633
595PhosphorylationMPSWFSSTASQQLYN
CCCCCCCCHHHHHCC		29.1819779198
621PhosphorylationNVRNEQESGAETTNK
CCCCCHHHCCCCCCC		42.8928889911
666PhosphorylationDDDLEVLSEELFEDV
CCHHHHHHHHHHHCC		33.9121440633
675PhosphorylationELFEDVPTKSQISKE
HHHHCCCCHHHHCHH		43.0827214570
680PhosphorylationVPTKSQISKEAEDND
CCCHHHHCHHCCCCC		19.4623749301
688PhosphorylationKEAEDNDSRKVESIN
HHCCCCCCHHHHHCC		40.0127214570
709PhosphorylationLIFDYDFSEDEEDNI
EEEECCCCCCCCCHH		41.0424961812
876PhosphorylationLKGMGPVSSIEVIAE
CCCCCCCCHHHHHHC		28.8222890988
877PhosphorylationKGMGPVSSIEVIAEF
CCCCCCCHHHHHHCC		24.0122890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PEX15_YEASTPEX15physical
11805837
MSH2_YEASTMSH2physical
9826691
RAD25_YEASTSSL2physical
8196602
TFB1_YEASTTFB1physical
8196602
RAD25_YEASTSSL2physical
8855246
RAD3_YEASTRAD3physical
8855246
SSL1_YEASTSSL1physical
8855246
TFB1_YEASTTFB1physical
8855246
RAD52_YEASTRAD52genetic
10430580
RAD26_YEASTRAD26genetic
12110180
RAD52_YEASTRAD52genetic
1374375
UBC2_YEASTRAD6genetic
1374375
HSM3_YEASTHSM3genetic
8964477
HMO1_YEASTHMO1genetic
8964477
SWM1_YEASTSWM1genetic
17314980
RAD18_YEASTRAD18genetic
17314980
TFS2_YEASTDST1genetic
12110180
RAD18_YEASTRAD18genetic
18931302
MDS3_YEASTMDS3genetic
18931302
SNT1_YEASTSNT1genetic
18931302
RAD9_YEASTRAD9genetic
20222011
TFB1_YEASTTFB1physical
23295669
MED17_YEASTSRB4physical
24298055
RPB1_YEASTRPO21physical
24298055
TPM1_YEASTTPM1genetic
24326185
SWE1_YEASTSWE1genetic
24326185
PCNA_YEASTPOL30physical
24674623
MAK5_YEASTMAK5genetic
27708008
NSE4_YEASTNSE4genetic
27708008
TIM22_YEASTTIM22genetic
27708008
TAF12_YEASTTAF12genetic
27708008
MOB2_YEASTMOB2genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
SMC5_YEASTSMC5genetic
27708008
OST2_YEASTOST2genetic
27708008
RPB2_YEASTRPB2genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
FYV10_YEASTFYV10genetic
27708008
MGA2_YEASTMGA2genetic
27708008
YJQ3_YEASTYJL163Cgenetic
27708008
MDM35_YEASTMDM35genetic
27708008
PHO84_YEASTPHO84genetic
27708008
SGS1_YEASTSGS1genetic
27708008
MDL2_YEASTMDL2genetic
27708008
YME1_YEASTYME1genetic
27708008
UBA3_YEASTUBA3genetic
27708008
MAP1_YEASTMAP1genetic
27453043
CDC42_YEASTCDC42genetic
27453043
RAD52_YEASTRAD52genetic
27453043
RAD5_YEASTRAD5genetic
27453043
SGS1_YEASTSGS1genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-583, ANDMASS SPECTROMETRY.

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