PHO84_YEAST - dbPTM
PHO84_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHO84_YEAST
UniProt AC P25297
Protein Name Inorganic phosphate transporter PHO84
Gene Name PHO84
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 587
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description High-affinity transporter for external inorganic phosphate. Is not an essential protein, since a constitutive, low affinity pI transporter exists in yeast..
Protein Sequence MSSVNKDTIHVAERSLHKEHLTEGGNMAFHNHLNDFAHIEDPLERRRLALESIDDEGFGWQQVKTISIAGVGFLTDSYDIFAINLGITMMSYVYWHGSMPGPSQTLLKVSTSVGTVIGQFGFGTLADIVGRKRIYGMELIIMIVCTILQTTVAHSPAINFVAVLTFYRIVMGIGIGGDYPLSSIITSEFATTKWRGAIMGAVFANQAWGQISGGIIALILVAAYKGELEYANSGAECDARCQKACDQMWRILIGLGTVLGLACLYFRLTIPESPRYQLDVNAKLELAAAAQEQDGEKKIHDTSDEDMAINGLERASTAVESLDNHPPKASFKDFCRHFGQWKYGKILLGTAGSWFTLDVAFYGLSLNSAVILQTIGYAGSKNVYKKLYDTAVGNLILICAGSLPGYWVSVFTVDIIGRKPIQLAGFIILTALFCVIGFAYHKLGDHGLLALYVICQFFQNFGPNTTTFIVPGECFPTRYRSTAHGISAASGKVGAIIAQTALGTLIDHNCARDGKPTNCWLPHVMEIFALFMLLGIFTTLLIPETKRKTLEEINELYHDEIDPATLNFRNKNNDIESSSPSQLQHEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSVNKDTI
------CCCCCHHHH		42.8922369663
3Phosphorylation-----MSSVNKDTIH
-----CCCCCHHHHH		28.5422369663
6Ubiquitination--MSSVNKDTIHVAE
--CCCCCHHHHHHHH		54.8417644757
8PhosphorylationMSSVNKDTIHVAERS
CCCCCHHHHHHHHHH		18.0022369663
15PhosphorylationTIHVAERSLHKEHLT
HHHHHHHHHCHHHCC		26.7417330950
18UbiquitinationVAERSLHKEHLTEGG
HHHHHHCHHHCCCCC		52.7222817900
22PhosphorylationSLHKEHLTEGGNMAF
HHCHHHCCCCCCCCC		34.2028889911
64UbiquitinationGFGWQQVKTISIAGV
CCCCCEEEEEEEEEE		35.4817644757
108UbiquitinationGPSQTLLKVSTSVGT
CCCHHEEEEECCCHH		36.9317644757
132UbiquitinationLADIVGRKRIYGMEL
HHHHHCCCCCCCHHH		36.9017644757
283UbiquitinationYQLDVNAKLELAAAA
CCCCHHHHHHHHHHH		36.9717644757
297UbiquitinationAQEQDGEKKIHDTSD
HHHHCCCCCCCCCCH		63.6622817900
298UbiquitinationQEQDGEKKIHDTSDE
HHHCCCCCCCCCCHH		40.7622817900
302PhosphorylationGEKKIHDTSDEDMAI
CCCCCCCCCHHHHHH		24.7417330950
303PhosphorylationEKKIHDTSDEDMAIN
CCCCCCCCHHHHHHH		45.0917330950
316PhosphorylationINGLERASTAVESLD
HHHHHHHHHHHHHHH		24.1017330950
317PhosphorylationNGLERASTAVESLDN
HHHHHHHHHHHHHHC		33.4617330950
321PhosphorylationRASTAVESLDNHPPK
HHHHHHHHHHCCCCC		34.1317330950
328UbiquitinationSLDNHPPKASFKDFC
HHHCCCCCCCHHHHH		62.2017644757
332UbiquitinationHPPKASFKDFCRHFG
CCCCCCHHHHHHHCC		47.6117644757
492UbiquitinationGISAASGKVGAIIAQ
CCHHCCCCHHHHHHH		34.6917644757
546UbiquitinationTLLIPETKRKTLEEI
HHHCHHHHHHHHHHH		50.6817644757
548UbiquitinationLIPETKRKTLEEINE
HCHHHHHHHHHHHHH		60.0417644757
571UbiquitinationATLNFRNKNNDIESS
HHCCCCCCCCCCCCC		53.5222817900
577PhosphorylationNKNNDIESSSPSQLQ
CCCCCCCCCCHHHHC		36.1322369663
578PhosphorylationKNNDIESSSPSQLQH
CCCCCCCCCHHHHCC		33.2122369663
579PhosphorylationNNDIESSSPSQLQHE
CCCCCCCCHHHHCCC		37.5422369663
581PhosphorylationDIESSSPSQLQHEA-
CCCCCCHHHHCCCC-		45.5322369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHO84_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHO84_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHO84_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBF1_YEASTCBF1genetic
1398064
PHO87_YEASTPHO87genetic
11779791
PHO89_YEASTPHO89genetic
11779791
PHO90_YEASTPHO90genetic
11779791
PHO91_YEASTPHO91genetic
11779791
PHO87_YEASTPHO87genetic
17804816
PHO89_YEASTPHO89genetic
17804816
PHO90_YEASTPHO90genetic
17804816
PHO91_YEASTPHO91genetic
17804816
GIT1_YEASTGIT1genetic
11779791
PHO88_YEASTPHO88physical
16093310
ALG1_YEASTALG1physical
16093310
MKAR_YEASTIFA38physical
16093310
GGC1_YEASTGGC1physical
16093310
FET5_YEASTFET5physical
16093310
SNL1_YEASTSNL1physical
16093310
PHO86_YEASTPHO86physical
16093310
STE24_YEASTSTE24physical
16093310
YET1_YEASTYET1physical
16093310
ELO3_YEASTELO3physical
16093310
GSF2_YEASTGSF2physical
16093310
COQ2_YEASTCOQ2physical
16093310
COS10_YEASTCOS10physical
16093310
ERP4_YEASTERP4physical
16093310
SEC63_YEASTSEC63physical
16093310
SLY41_YEASTSLY41physical
16093310
TPO3_YEASTTPO3physical
16093310
SPL2_YEASTSPL2genetic
20688911
PHO89_YEASTPHO89genetic
20726779
PHO4_YEASTPHO4genetic
21143198
PHO87_YEASTPHO87genetic
21143198
PHO89_YEASTPHO89genetic
21143198
PHO90_YEASTPHO90genetic
21143198
KCS1_YEASTKCS1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
INP53_YEASTINP53genetic
21623372
TKT1_YEASTTKL1genetic
21623372
SPEE_YEASTSPE3genetic
21623372
GPD1_YEASTGPD1genetic
21623372
IDH1_YEASTIDH1genetic
21623372
PDX3_YEASTPDX3genetic
21623372
QCR6_YEASTQCR6genetic
21623372
ARO1_YEASTARO1genetic
21623372
GSHB_YEASTGSH2genetic
21623372
COQ7_YEASTCAT5genetic
21623372
6PGD1_YEASTGND1genetic
21623372
HNT2_YEASTHNT2genetic
21623372
MTAP_YEASTMEU1genetic
21623372
GIT1_YEASTGIT1genetic
21623372
GAL10_YEASTGAL10genetic
21623372
PTE1_YEASTTES1genetic
21623372
CHO2_YEASTCHO2genetic
21623372
SUMT_YEASTMET1genetic
21623372
URA8_YEASTURA8genetic
21623372
ODP2_YEASTLAT1genetic
21623372
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
ETR1_YEASTETR1genetic
27708008
WDR59_YEASTMTC5genetic
27708008
RV167_YEASTRVS167genetic
27708008
ASK10_YEASTASK10genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
PIN4_YEASTPIN4genetic
27708008
AIM4_YEASTAIM4genetic
27708008
CHK1_YEASTCHK1genetic
27708008
MGR1_YEASTMGR1genetic
27708008
TRM3_YEASTTRM3genetic
27708008
ENT1_YEASTENT1genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
GYP7_YEASTGYP7genetic
27708008
CTH1_YEASTCTH1genetic
27708008
UME6_YEASTUME6genetic
27708008
FIT1_YEASTFIT1genetic
27708008
FDC1_YEASTFDC1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
MET10_YEASTMET10genetic
27708008
RL29_YEASTRPL29genetic
27708008
QCR6_YEASTQCR6genetic
27708008
SA155_YEASTSAP155genetic
27708008
NADC_YEASTBNA6genetic
27708008
ARO8_YEASTARO8genetic
27708008
MLP2_YEASTMLP2genetic
27708008
POM34_YEASTPOM34genetic
27708008
YM8C_YEASTYMR262Wgenetic
27708008
RTG1_YEASTRTG1genetic
27708008
SFL1_YEASTSFL1genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
YP078_YEASTYPR078Cgenetic
27708008
SPL2_YEASTSPL2genetic
27811238
SPL2_YEASTSPL2genetic
29236696
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHO84_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-22; THR-302; SER-303;SER-316; THR-317; SER-321; SER-577; SER-578; SER-579 AND SER-581, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-317; SER-321 ANDSER-578, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302; SER-303; SER-316;THR-317; SER-321; SER-577; SER-579 AND SER-581, AND MASS SPECTROMETRY.
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302; SER-303; THR-317;SER-321 AND SER-579, UBIQUITINATION AT LYS-6 AND LYS-298, AND MASSSPECTROMETRY.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-302; SER-303; THR-317;SER-321 AND SER-579, UBIQUITINATION AT LYS-6 AND LYS-298, AND MASSSPECTROMETRY.

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