CTH1_YEAST - dbPTM
CTH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CTH1_YEAST
UniProt AC P47976
Protein Name mRNA decay factor CTH1
Gene Name CTH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 325
Subcellular Localization
Protein Description Binds to specific AU-rich elements (ARE) in the 3'-untranslated region of target mRNAs and promotes their degradation. In response to iron deficiency, promotes the decay of many mRNAs encoding proteins involved in iron-dependent pathways. Negatively regulates primarily iron-dependent mitochondrial processes including respiration and amino acid biosynthesis..
Protein Sequence MMPNVAPNSYYLNIPNANSTSTTTSSIFSDLNKEYESKIKEIEEYYIKTLLNENTDNDDSSSSEGHNINETDILSEYSPRPSPWLPSKPNCYHPLGDFKDLIISDSRPTNTLPINNPFAGNNNISTLATTEKKRKKRSLEVEINPTYTTSAFSLPLTAENLQKLSQVDSQSTGLPYTLPIQKTTKLEPCRRAPLQLPQLVNKTLYKTELCESFTIKGYCKYGNKCQFAHGLNELKFKKKSNNYRTKPCINWSKLGYCPYGKRCCFKHGDDKDVEIYQNANDGRSKDTALTPLPTSLAPSNNDNITNLSKPRNLHTSVKALQRMTW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
38UbiquitinationLNKEYESKIKEIEEY
CCHHHHHHHHHHHHH		45.9517644757
40UbiquitinationKEYESKIKEIEEYYI
HHHHHHHHHHHHHHH		57.2717644757
48UbiquitinationEIEEYYIKTLLNENT
HHHHHHHHHHHHCCC		19.5917644757
202UbiquitinationQLPQLVNKTLYKTEL
CHHHHHCCCCCCCCC		32.2117644757
253UbiquitinationKPCINWSKLGYCPYG
CCCCCHHHCCCCCCC		37.2323749301
266UbiquitinationYGKRCCFKHGDDKDV
CCCCEEEECCCCCCE		32.5317644757
271UbiquitinationCFKHGDDKDVEIYQN
EEECCCCCCEEEEEC		69.3017644757
285UbiquitinationNANDGRSKDTALTPL
CCCCCCCCCCCCCCC		58.7117644757
309UbiquitinationDNITNLSKPRNLHTS
CCCCCCCCCCCHHHH		51.6817644757
324PhosphorylationVKALQRMTW------
HHHHHHCCC------		30.1621440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CTH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CTH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CTH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GLRX5_YEASTGRX5physical
18467557
CTH2_YEASTTIS11genetic
20008079
HXT2_YEASTHXT2genetic
20093466
CTH2_YEASTTIS11genetic
21135132
ZAP1_YEASTZAP1genetic
20959818
RDS2_YEASTRDS2genetic
20959818
NDT80_YEASTNDT80genetic
20959818
DAL82_YEASTDAL82genetic
20959818
PHD1_YEASTPHD1genetic
20959818
URE2_YEASTURE2genetic
20959818
UPC2_YEASTUPC2genetic
20959818
SUT2_YEASTSUT2genetic
20959818
IME1_YEASTIME1genetic
20959818
CYC8_YEASTCYC8genetic
20959818
BDF1_YEASTBDF1genetic
20959818
GAL3_YEASTGAL3genetic
20959818
CUP2_YEASTCUP2genetic
20959818
MET31_YEASTMET31genetic
20959818
YFM7_YEASTYFR057Wgenetic
20959818
ISW2_YEASTISW2genetic
20959818
YG2A_YEASTYGR067Cgenetic
20959818
CTH1_YEASTCTH1physical
23530061
CTH2_YEASTTIS11physical
23530061
DAL81_YEASTDAL81genetic
27708008
EAF7_YEASTEAF7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CTH1_YEAST

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Related Literatures of Post-Translational Modification

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