| UniProt ID | EAF7_YEAST | |
|---|---|---|
| UniProt AC | P53911 | |
| Protein Name | Chromatin modification-related protein EAF7 | |
| Gene Name | EAF7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 425 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.. | |
| Protein Sequence | MVVHWTIVDEIRLLRWASEFKPAGIHKHFHMFCIVERMNSPDKYPVTLLQKETMKLGKVFTAKDIWDKLSQSYNLEKIDEMENTYSLEATTESSRNGNGNGDDAEIHEETLLELNNRIRVRKQDFTLPWEEYGELILENARKSPNSNEEYPRVEDMNEKDSTIPKESPSTDLKNDNNKQEKNATIKVKELPEYHTEENDSPIDVQKEPIKEVQSDEKELQREHMSEEEQKMKSTNKTAAPVRKSQRLKRSKEVKFEDEEKEEIEEDNTKDEEQKEKKEEIQEPKITHNEEVDKEKNENEEGDDEREKSTSYENTNGSESEGVDEGVDEELGYESEREAEGKGKQIESEGGNLKKKTENKKGDDQQDDTKKDSKDKNEPLAKRTRHSSSTGNTSNETSPKRKRRKAGSRKNSPPATRVSSRLRNKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Phosphorylation | IRLLRWASEFKPAGI HHHHHHHHHCCCCCH | 36.28 | 24930733 | |
| 40 | Phosphorylation | CIVERMNSPDKYPVT EEEECCCCCCCCCEE | 25.73 | 24930733 | |
| 143 | Phosphorylation | ILENARKSPNSNEEY HHHHHHCCCCCCCCC | 24.62 | 27214570 | |
| 146 | Phosphorylation | NARKSPNSNEEYPRV HHHCCCCCCCCCCCH | 49.34 | 27214570 | |
| 161 | Phosphorylation | EDMNEKDSTIPKESP HHCCCCCCCCCCCCC | 39.03 | 22369663 | |
| 162 | Phosphorylation | DMNEKDSTIPKESPS HCCCCCCCCCCCCCC | 51.97 | 22369663 | |
| 167 | Phosphorylation | DSTIPKESPSTDLKN CCCCCCCCCCCCCCC | 30.21 | 22369663 | |
| 169 | Phosphorylation | TIPKESPSTDLKNDN CCCCCCCCCCCCCCC | 43.78 | 21440633 | |
| 170 | Phosphorylation | IPKESPSTDLKNDNN CCCCCCCCCCCCCCC | 49.05 | 22369663 | |
| 193 | Phosphorylation | KVKELPEYHTEENDS EEEECCCCCCCCCCC | 16.47 | 22369663 | |
| 195 | Phosphorylation | KELPEYHTEENDSPI EECCCCCCCCCCCCC | 44.06 | 22369663 | |
| 200 | Phosphorylation | YHTEENDSPIDVQKE CCCCCCCCCCCCCCC | 35.02 | 22369663 | |
| 214 | Phosphorylation | EPIKEVQSDEKELQR CCHHHHCCCHHHHHH | 53.57 | 28889911 | |
| 225 | Phosphorylation | ELQREHMSEEEQKMK HHHHHHCCHHHHHHH | 43.70 | 25521595 | |
| 286 | Phosphorylation | EIQEPKITHNEEVDK HHCCCCCCCCHHHHH | 25.44 | 27017623 | |
| 308 | Phosphorylation | GDDEREKSTSYENTN CCCHHHHHHCCCCCC | 20.17 | 24961812 | |
| 309 | Phosphorylation | DDEREKSTSYENTNG CCHHHHHHCCCCCCC | 46.53 | 24961812 | |
| 310 | Phosphorylation | DEREKSTSYENTNGS CHHHHHHCCCCCCCC | 37.22 | 24961812 | |
| 311 | Phosphorylation | EREKSTSYENTNGSE HHHHHHCCCCCCCCC | 17.18 | 19823750 | |
| 314 | Phosphorylation | KSTSYENTNGSESEG HHHCCCCCCCCCCCC | 29.08 | 24961812 | |
| 317 | Phosphorylation | SYENTNGSESEGVDE CCCCCCCCCCCCCCC | 39.76 | 19795423 | |
| 319 | Phosphorylation | ENTNGSESEGVDEGV CCCCCCCCCCCCCCC | 41.15 | 19795423 | |
| 334 | Phosphorylation | DEELGYESEREAEGK CHHHCCCCHHHHCCC | 33.21 | 21551504 | |
| 343 | Acetylation | REAEGKGKQIESEGG HHHCCCCCCCCCCCC | 52.14 | 24489116 | |
| 347 | Phosphorylation | GKGKQIESEGGNLKK CCCCCCCCCCCCCCC | 43.07 | 28889911 | |
| 381 | Acetylation | DKNEPLAKRTRHSSS CCCCCHHHHHCCCCC | 63.08 | 23572591 | |
| 383 | Phosphorylation | NEPLAKRTRHSSSTG CCCHHHHHCCCCCCC | 31.84 | 19823750 | |
| 386 | Phosphorylation | LAKRTRHSSSTGNTS HHHHHCCCCCCCCCC | 23.77 | 19823750 | |
| 387 | Phosphorylation | AKRTRHSSSTGNTSN HHHHCCCCCCCCCCC | 26.29 | 19823750 | |
| 388 | Phosphorylation | KRTRHSSSTGNTSNE HHHCCCCCCCCCCCC | 43.26 | 19823750 | |
| 389 | Phosphorylation | RTRHSSSTGNTSNET HHCCCCCCCCCCCCC | 36.08 | 19823750 | |
| 392 | Phosphorylation | HSSSTGNTSNETSPK CCCCCCCCCCCCCCH | 33.98 | 19823750 | |
| 393 | Phosphorylation | SSSTGNTSNETSPKR CCCCCCCCCCCCCHH | 36.35 | 19823750 | |
| 396 | Phosphorylation | TGNTSNETSPKRKRR CCCCCCCCCCHHHHH | 55.36 | 19823750 | |
| 397 | Phosphorylation | GNTSNETSPKRKRRK CCCCCCCCCHHHHHC | 23.42 | 19823750 | |
| 399 | Acetylation | TSNETSPKRKRRKAG CCCCCCCHHHHHCCC | 71.03 | 23572591 | |
| 409 | Acetylation | RRKAGSRKNSPPATR HHCCCCCCCCCCHHH | 64.57 | 23572591 | |
| 411 | Phosphorylation | KAGSRKNSPPATRVS CCCCCCCCCCHHHHH | 34.98 | 17563356 | |
| 415 | Phosphorylation | RKNSPPATRVSSRLR CCCCCCHHHHHHHHH | 37.06 | 30377154 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EAF7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EAF7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-167; SER-200AND SER-225, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225; SER-393; SER-397AND SER-411, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225, AND MASSSPECTROMETRY. | |
| "Phosphoproteome analysis by mass spectrometry and its application toSaccharomyces cerevisiae."; Ficarro S.B., McCleland M.L., Stukenberg P.T., Burke D.J., Ross M.M.,Shabanowitz J., Hunt D.F., White F.M.; Nat. Biotechnol. 20:301-305(2002). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393 AND SER-397, ANDMASS SPECTROMETRY. | |
