| UniProt ID | KES1_YEAST | |
|---|---|---|
| UniProt AC | P35844 | |
| Protein Name | Oxysterol-binding protein homolog 4 | |
| Gene Name | KES1 {ECO:0000312|SGD:S000006066} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 434 | |
| Subcellular Localization | Golgi apparatus membrane . | |
| Protein Description | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1 phosphatase in the endoplasmic reticulum. [PubMed: 16136145] | |
| Protein Sequence | MSQYASSSSWTSFLKSIASFNGDLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTKWFISTLKSQYCSRNESLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSIFNDKNKVKLQGYNQIKASFTKSLMLTVKQFGHTMLDIKDESYLVTPPPLHIEGILVASPFVELEGKSYIQSSTGLLCVIEFSGRGYFSGKKNSFKARIYKDSKDSKDKEKALYTISGQWSGSSKIIKANKKEESRLFYDAARIPAEHLNVKPLEEQHPLESRKAWYDVAGAIKLGDFNLIAKTKTELEETQRELRKEEEAKGISWQRRWFKDFDYSVTPEEGALVPEKDDTFLKLASALNLSTKNAPSGTLVGDKEDRKEDLSSIHWRFQRELWDEEKEIVL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSQYASSSS ------CCCCCCCHH | 31.72 | 22369663 | |
| 4 | Phosphorylation | ----MSQYASSSSWT ----CCCCCCCHHHH | 10.92 | 28132839 | |
| 6 | Phosphorylation | --MSQYASSSSWTSF --CCCCCCCHHHHHH | 26.31 | 22369663 | |
| 7 | Phosphorylation | -MSQYASSSSWTSFL -CCCCCCCHHHHHHH | 21.88 | 22369663 | |
| 8 | Phosphorylation | MSQYASSSSWTSFLK CCCCCCCHHHHHHHH | 27.65 | 22369663 | |
| 9 | Phosphorylation | SQYASSSSWTSFLKS CCCCCCHHHHHHHHH | 36.00 | 22369663 | |
| 11 | Phosphorylation | YASSSSWTSFLKSIA CCCCHHHHHHHHHHH | 16.14 | 22369663 | |
| 12 | Phosphorylation | ASSSSWTSFLKSIAS CCCHHHHHHHHHHHH | 23.48 | 22369663 | |
| 95 | Phosphorylation | WFISTLKSQYCSRNE HHHHHHHHHHHCCCC | 29.51 | 27017623 | |
| 97 | Phosphorylation | ISTLKSQYCSRNESL HHHHHHHHHCCCCCC | 10.24 | 27017623 | |
| 103 | Phosphorylation | QYCSRNESLGSEKKP HHHCCCCCCCCCCCC | 41.39 | 27017623 | |
| 108 | Acetylation | NESLGSEKKPLNPFL CCCCCCCCCCCCHHH | 62.48 | 24489116 | |
| 109 | Ubiquitination | ESLGSEKKPLNPFLG CCCCCCCCCCCHHHH | 51.16 | 23749301 | |
| 109 | Acetylation | ESLGSEKKPLNPFLG CCCCCCCCCCCHHHH | 51.16 | 24489116 | |
| 156 | Ubiquitination | AFSIFNDKNKVKLQG EEEEECCCCCEEECC | 60.83 | 22817900 | |
| 158 | Ubiquitination | SIFNDKNKVKLQGYN EEECCCCCEEECCCH | 46.62 | 22817900 | |
| 160 | Ubiquitination | FNDKNKVKLQGYNQI ECCCCCEEECCCHHH | 36.38 | 23749301 | |
| 168 | Acetylation | LQGYNQIKASFTKSL ECCCHHHHHHHHHHH | 28.37 | 24489116 | |
| 185 | Phosphorylation | TVKQFGHTMLDIKDE EHHHHCCEEEEECCC | 21.58 | 19795423 | |
| 240 | Phosphorylation | FSGRGYFSGKKNSFK ECCCCCCCCCCCEEE | 41.02 | 23749301 | |
| 247 | Acetylation | SGKKNSFKARIYKDS CCCCCEEEEEEECCC | 36.25 | 25381059 | |
| 260 | Acetylation | DSKDSKDKEKALYTI CCCCCCCHHHEEEEE | 65.92 | 24489116 | |
| 315 | Ubiquitination | QHPLESRKAWYDVAG CCCCCCCCHHHHHHH | 53.18 | 23749301 | |
| 334 | Ubiquitination | GDFNLIAKTKTELEE CCCEEEEECHHHHHH | 43.49 | 22817900 | |
| 335 | Phosphorylation | DFNLIAKTKTELEET CCEEEEECHHHHHHH | 33.89 | 22369663 | |
| 336 | 2-Hydroxyisobutyrylation | FNLIAKTKTELEETQ CEEEEECHHHHHHHH | 39.02 | - | |
| 336 | Ubiquitination | FNLIAKTKTELEETQ CEEEEECHHHHHHHH | 39.02 | 23749301 | |
| 337 | Phosphorylation | NLIAKTKTELEETQR EEEEECHHHHHHHHH | 51.54 | 22369663 | |
| 342 | Phosphorylation | TKTELEETQRELRKE CHHHHHHHHHHHHHH | 24.45 | 22369663 | |
| 367 | Phosphorylation | RWFKDFDYSVTPEEG HHHHCCCCEECCCCC | 12.67 | 22369663 | |
| 368 | Phosphorylation | WFKDFDYSVTPEEGA HHHCCCCEECCCCCC | 22.74 | 22369663 | |
| 370 | Phosphorylation | KDFDYSVTPEEGALV HCCCCEECCCCCCCC | 21.02 | 22369663 | |
| 380 | Acetylation | EGALVPEKDDTFLKL CCCCCCCCCHHHHHH | 55.63 | 24489116 | |
| 383 | Phosphorylation | LVPEKDDTFLKLASA CCCCCCHHHHHHHHH | 40.79 | 22369663 | |
| 389 | Phosphorylation | DTFLKLASALNLSTK HHHHHHHHHHCCCCC | 43.66 | 22369663 | |
| 394 | Phosphorylation | LASALNLSTKNAPSG HHHHHCCCCCCCCCC | 35.94 | 22369663 | |
| 395 | Phosphorylation | ASALNLSTKNAPSGT HHHHCCCCCCCCCCC | 31.33 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KES1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KES1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KES1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-337; THR-370; THR-383AND SER-389, AND MASS SPECTROMETRY. | |
