FMP27_YEAST - dbPTM
FMP27_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FMP27_YEAST
UniProt AC Q06179
Protein Name Protein FMP27, mitochondrial
Gene Name FMP27
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 2628
Subcellular Localization Mitochondrion .
Protein Description
Protein Sequence MMFPINVLLYKWLIFAVTFLWSCKILLRKLLGINITWINLFKLEICGLSLEDGTVRLKSVRFAVFERKLFIKGLRIDSKKSSTNDLHKELPREEERTFIETPEDNGGGFISKILSLSQYWLNGVTIILEDTQLVNNDITIEKFGFFLSIDNSKHIKSLRFDSFLRKLLWNGQTIIADAIFIVNTNLLIGEIMNPLKDGLQVGLDLKLGDLNIPMNLLNLFINKENVDLMSNEKLLQRLADTTKANEELKDEDIAKMKDDLVYAMEKFVDRIKPLKEMNVTVDKLQIKDFPLTNHPELLGMNKYISYNVLVSNINFNTNRFRNEMPGYTLIFEERDSPFKFSIIMARFNIYLNLNRKHQSHAKQLKIIEIPNVSIFGETNLFSQKFRLSNNLHAKELENAIFNIKGNISSLTIDMDPVNISFIKCFLSNIKVFTSSCPKNKILKENSHVKFLTRRRVLFDYFKCFLPLINMKFTLDDPKFVINDKDDLIIGKFSVFMISHHSKRYTLGNNLMEEKEETQHIFYESHWNVELLDMKLQHIIKHQKYEHTILRVDSIAIEEKVQLLPDILCSANADIDTLMLDLSELPTMVMLSELVHNLDSQLANVEENYFKEFYEKFASNLQNMKAECSNMAKCLRQKEILPSDFMFQQLPDFFDYIKINIRDISSTLGARSVFMPRDVFSSVDSQSSKDLIDGKLRKYCNTVEKLQIALFGDKTQWHNKIGSNHATMVRSGQLTNFSKDNKQNPNHKSSIADLDDISTSDATEVNHLWNINLLVNDITTSIIGETPEVSEELSTKTVSKVSNLSIKLFPDTESFSSNESDSKIILQINHSRGTSVVSLMSIFLAVSGIHTLNQIFGHCIHQKMRQSKTKQYFLALSESKKKSCIKSIKWGQLKELLEINFSSEYISQIIALPNGLRTKFEPTSTFITVKNCNTISVSGQYFRMMVESPTQPNFWERMICINGFKVMIHIDLLKQQMKKLNSLQNWEKLPSAITLENDSWHFSIPHHFEMFKIIDSIPTIFKSIKQMLYSLKTSKDDLIIFPHKIETPLSLPKIKLKSKRWLFSISDDPLEAELNTIFQIGLQEQRERLAKLQEFNKRISEDLIKSQKNAKEMKDDFEAIDNAILKHRTGLWAKDGKKRLRKSATDSEIPLTPAALNINGKRDDRPDRTQFISPEIENAYNTLLANFSDSWIKRVKEYKVKERREFDKNFSFLWGFIDYTKLPKDINKKVLPFSTNPFLMNLIIENIDIDIIRPSCGIENIPNFIHDVGKGVPKNTEYSIMIPMHLDAKFSEVRWHLRDYPLPFVSIPPLSSTQSKETIPMRIYGDFMITEDMLQSDRELRTLFVPLIPSVTVENTDRYYSLFVPRTMTSAKIFTDLNFEINSNHTTRVTWGGSYQPAIQQTMQCLDNFSKPPLDPSVKLGFWDKTRYLFHGKINIVWKKRGKFEISLKGAKSPYMLGGESAGFIVGFDGNVNLKCNEDNDPKKFLSCSADKVHFSIPNYFAKPLLVWSRPSTNTMFIPNQDDTNMQRYASFYYLLNTTSSKNEKADKEIMGKSFIEKTGIKLSGGMTLDMGILFERLGPSLNERTFESKKHYLTRLCNPIYVQDLSKHDSYAGFRSDFIHMSFGLSSNSNSAYNAMQLSPNGFKAFFVWWKSFSGNFPVRRGPLFGLQSISPKFGEHLYTISYHADVSPLFINYMYHNADADQILRKNYLEVAEFAGLKAKSSHFIMDLHQRKEVLTEYQAGLNVRRRVMKLKFLAGDVVCQDVDIRTVSGEFSKLNYIEEKEDAEYDIFDNDMSWLDITDFQDAFFINPDNYLPKIKIMPFAFSPQFAYQKRASYGDKYQVDPKTCKPITPFDNRVSHGCTLGHNVSLRTDLVEKRVTVLKKFREKLQEGIRKNKSAGVSEENLNDLLSKANSSVENAELLLKDFQKIFKQHEAGQTEQPFHFDSLNLLKNTKKTLKQFEHRFFIFNVLLKWNEDARSAIFKFFYYANLSNEFASLASGKGLREFEDVIKQREMTDDTTSMEAIPEGTDKANTTKQCHSCDDTEFTTENLLNIFEKNITQLSCDIKNKIHHKFFVQFITPQIQLTSLENPEACVLVSSPFFMLKTLEFDANTTSNTYMQDIFLKRHGILFGNANAFLFNKKDYQEFFELYFGSSSYGQDKKEQWPPWLGLELGFEPSALKKKAVVRNISALLHHQKLAPFSAKYDSLKDKIEDNICGYVPQVNVQVNSDEYLMLTKMALKLFLYVEPEDEELKKYIEKLIIGYDIYDTAQTRKFVNDLHDSEQILAVVEKELLFKRSLLDDIGKLDLSNIHNERMHQLLRLYILRKVFTSNGNNYINRTLVWNIKVNETILHLLDKIDKPFLDIAVAKLNFQRIQHTMGLRKNTVTVKMMQIFDLGENVNYHCILGPLITSSGNDTVGLASDVPLVQITWDVDKPVGGIKVVKNVETTLSSLTIKLEEDRLNKLFEWLSLKELIYDGNGDDDDGASSIFDMVSSESEEGKIEFSEDISSDFNEMLKRSSDYMIVEDLKLNSFKLCISYKGKGKMRLANVTNFVFNFPTLRLSNQTLRVTDLLLALKKVLIKVLIKHTGRFIGNKLKRNSKENKIADDTSPLKQLTTYNSYTEPEELR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
680PhosphorylationFMPRDVFSSVDSQSS
ECCHHHHHCCCCCCC		29.3327017623
681PhosphorylationMPRDVFSSVDSQSSK
CCHHHHHCCCCCCCH		20.6227017623
694AcetylationSKDLIDGKLRKYCNT
CHHHHHHHHHHHCCH		41.1724489116
730PhosphorylationNHATMVRSGQLTNFS
CCCEEEECCCCCCCC		21.3427017623
734PhosphorylationMVRSGQLTNFSKDNK
EEECCCCCCCCCCCC		26.7427017623
737PhosphorylationSGQLTNFSKDNKQNP
CCCCCCCCCCCCCCC		40.9627017623
738UbiquitinationGQLTNFSKDNKQNPN
CCCCCCCCCCCCCCC		62.2723749301
1142PhosphorylationGKKRLRKSATDSEIP
CHHHHHHCCCCCCCC		29.9325521595
1144PhosphorylationKRLRKSATDSEIPLT
HHHHHCCCCCCCCCC		47.3425521595
1146PhosphorylationLRKSATDSEIPLTPA
HHHCCCCCCCCCCHH		32.8225521595
1616PhosphorylationDSYAGFRSDFIHMSF
CCCCCCCCCCCHHHC		34.3127017623
1622PhosphorylationRSDFIHMSFGLSSNS
CCCCCHHHCCCCCCC		11.2927017623
1626PhosphorylationIHMSFGLSSNSNSAY
CHHHCCCCCCCCCHH		28.0527017623
1627PhosphorylationHMSFGLSSNSNSAYN
HHHCCCCCCCCCHHH		49.6927017623
1629PhosphorylationSFGLSSNSNSAYNAM
HCCCCCCCCCHHHHH		33.8227017623
1639PhosphorylationAYNAMQLSPNGFKAF
HHHHHCCCCCCCEEE		10.2227017623
1897PhosphorylationEGIRKNKSAGVSEEN
HHHHCCCCCCCCHHH		39.3819779198
1901PhosphorylationKNKSAGVSEENLNDL
CCCCCCCCHHHHHHH		37.9727214570
1910PhosphorylationENLNDLLSKANSSVE
HHHHHHHHHHCHHHH		36.7019779198
1986PhosphorylationSAIFKFFYYANLSNE
HHHHHHHHHHCCCHH		12.5619779198
1991PhosphorylationFFYYANLSNEFASLA
HHHHHCCCHHHHHHH		33.8419779198
1999PhosphorylationNEFASLASGKGLREF
HHHHHHHCCCCHHHH		46.4619779198
2016PhosphorylationVIKQREMTDDTTSME
HHHHHHCCCCCCCCC		26.4327717283
2019PhosphorylationQREMTDDTTSMEAIP
HHHCCCCCCCCCCCC		24.4725521595
2020PhosphorylationREMTDDTTSMEAIPE
HHCCCCCCCCCCCCC		32.8220377248
2021PhosphorylationEMTDDTTSMEAIPEG
HCCCCCCCCCCCCCC		19.4021551504
2029PhosphorylationMEAIPEGTDKANTTK
CCCCCCCCCCCCCCC		32.4427717283
2291AcetylationQILAVVEKELLFKRS
HHHHHHHHHHHHCHH		41.8925381059
2298PhosphorylationKELLFKRSLLDDIGK
HHHHHCHHHHHCCCC		33.6028889911
2330PhosphorylationYILRKVFTSNGNNYI
HHHHHHHCCCCCCCE		25.0328889911
2331PhosphorylationILRKVFTSNGNNYIN
HHHHHHCCCCCCCEE		31.1328889911
2336PhosphorylationFTSNGNNYINRTLVW
HCCCCCCCEEEEEEE		11.9928889911
2340PhosphorylationGNNYINRTLVWNIKV
CCCCEEEEEEEEEEC		22.6028889911
2387PhosphorylationGLRKNTVTVKMMQIF
CCCCCCEEEEEEEEE		16.6328889911
2510PhosphorylationEFSEDISSDFNEMLK
EECHHHCHHHHHHHH		46.7028747907
2609PhosphorylationENKIADDTSPLKQLT
CCCCCCCCCCHHHHC		32.5628889911
2610PhosphorylationNKIADDTSPLKQLTT
CCCCCCCCCHHHHCC		34.9221440633
2616PhosphorylationTSPLKQLTTYNSYTE
CCCHHHHCCCCCCCC		25.4127017623
2617PhosphorylationSPLKQLTTYNSYTEP
CCHHHHCCCCCCCCC		29.3319779198
2618PhosphorylationPLKQLTTYNSYTEPE
CHHHHCCCCCCCCCH		9.2521440633
2620PhosphorylationKQLTTYNSYTEPEEL
HHHCCCCCCCCCHHH		24.0219823750
2621PhosphorylationQLTTYNSYTEPEELR
HHCCCCCCCCCHHHC		16.1028889911
2622PhosphorylationLTTYNSYTEPEELR-
HCCCCCCCCCHHHC-		44.9025752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FMP27_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FMP27_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FMP27_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHG1_YEASTSHG1genetic
20093466
THRC_YEASTTHR4genetic
20093466
SPT3_YEASTSPT3genetic
20093466
MET7_YEASTSTR2genetic
20093466
VPS24_YEASTVPS24genetic
20093466
MED9_YEASTCSE2genetic
20093466
RS10A_YEASTRPS10Agenetic
20093466
SPC72_YEASTSPC72physical
22875988
SPR3_YEASTSPR3physical
22875988
ETP1_YEASTETP1physical
22875988
CDC11_YEASTCDC11physical
22875988
NST1_YEASTNST1physical
22875988
RLF2_YEASTRLF2physical
22875988
APN2_YEASTAPN2genetic
27708008
PLPHP_YEASTYBL036Cgenetic
27708008
TEC1_YEASTTEC1genetic
27708008
THRC_YEASTTHR4genetic
27708008
NBP2_YEASTNBP2genetic
27708008
VPS24_YEASTVPS24genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FMP27_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1142; SER-1901;SER-2021; TYR-2618; SER-2620 AND THR-2622, AND MASS SPECTROMETRY.

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