| UniProt ID | MET7_YEAST | |
|---|---|---|
| UniProt AC | P47164 | |
| Protein Name | Cystathionine gamma-synthase | |
| Gene Name | STR2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 639 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).. | |
| Protein Sequence | MISRTIGESIPPNTKHAVSVCLPTWEATVGYEEGESSIINSLTTGYPRFFIHKSIKKLCEILSAKYSMEDEACLCFPSYKVANRCREFIKVKTGLSTKVRILQLCTPKPMNQEEKLWRRECKITVVFVDQEIFPVMKQYWQHSGEIVSSRMAEYILHELQVKDNLKKMETVDNGKKFMTEDENRVNEEYIETRFGRNLNFLAADKAKYLIRKRIATKVVEKIDSEGLSDLFSFEHYNESNGPFNVGSGEALDDDQLNSDIPAETITSMGESGSNSTFENTATDDLKFHVNPNTDVYLFPSGMASIFTAHRLLLNFDAKRLSRSSSRQDKLIGYGPPFKKTVMFGFPYTDTLSILRKFNHTHFLGQGDSTSMNALKNILHSGEQILAVFIEAPSNPLLKMGDLQELKRLSDLYSFYIVVDETVGGFVNIDVLPYADIVCSSLTKIFSGDSNVIAGSLVLNPRGKIYEFARKFMKTEDGYEDCLWCEDALCLERNSRDFVERTIKVNTNTDILLKRVLLPQVGKLFKKIYYPSLTSEDTKRNYDSVMSTKDGGYGGLFSLTFFNIEEAKKFFNNLELCKGPSLGTNFTLACPYAIIAHYQELDEVAQYGVETNLVRVSVGLENSDVLCNVFQRAIEKALGE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MISRTIGESI -----CCCCCCCCCC | 23.28 | 19823750 | |
| 5 | Phosphorylation | ---MISRTIGESIPP ---CCCCCCCCCCCC | 26.92 | 19823750 | |
| 9 | Phosphorylation | ISRTIGESIPPNTKH CCCCCCCCCCCCCCC | 34.87 | 19795423 | |
| 14 | Phosphorylation | GESIPPNTKHAVSVC CCCCCCCCCCEEEEE | 29.95 | 19823750 | |
| 275 | Phosphorylation | MGESGSNSTFENTAT CCCCCCCCCCCCCCC | 35.85 | - | |
| 409 | Phosphorylation | LQELKRLSDLYSFYI HHHHHHHHHHCEEEE | 29.60 | 30377154 | |
| 412 | Phosphorylation | LKRLSDLYSFYIVVD HHHHHHHCEEEEEEE | 11.17 | 30377154 | |
| 413 | Phosphorylation | KRLSDLYSFYIVVDE HHHHHHCEEEEEEEC | 20.90 | 30377154 | |
| 415 | Phosphorylation | LSDLYSFYIVVDETV HHHHCEEEEEEECCC | 6.20 | 30377154 | |
| 439 | Phosphorylation | PYADIVCSSLTKIFS CHHHHHHHCCCCHHC | 19.93 | 30377154 | |
| 440 | Phosphorylation | YADIVCSSLTKIFSG HHHHHHHCCCCHHCC | 34.62 | 30377154 | |
| 443 | N6-(pyridoxal phosphate)lysine | IVCSSLTKIFSGDSN HHHHCCCCHHCCCCC | 47.23 | - | |
| 443 | Other | IVCSSLTKIFSGDSN HHHHCCCCHHCCCCC | 47.23 | - | |
| 528 | Phosphorylation | GKLFKKIYYPSLTSE HHHHHHHHCCCCCCH | 20.43 | 27017623 | |
| 534 | Phosphorylation | IYYPSLTSEDTKRNY HHCCCCCCHHHCCCH | 38.48 | 27017623 | |
| 537 | Phosphorylation | PSLTSEDTKRNYDSV CCCCCHHHCCCHHCC | 28.05 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MET7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MET7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MET7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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