| UniProt ID | SYFB_YEAST | |
|---|---|---|
| UniProt AC | P15624 | |
| Protein Name | Phenylalanine--tRNA ligase beta subunit | |
| Gene Name | FRS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 595 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | ||
| Protein Sequence | MPTVSVNKQQLFDLLGKNYTSQEFDELCFEFGMEMDEDTTEEALKTGEEPELKLDISANRYDLLCIEGISQSLNEYLERKERPDYKLSKPTTKLIIDKSTEQIRPFATAAVLRNIKLNEKSYASFIALQDKLHANLCRNRSLVAMGTHDLDSIEGPFHYRALPPKDIKFVPLNQTQEFTGDKLIEFYKSPEQKNNIGRYVHIIEDSPVFPVIMDSKDRVCSLPPLINSEHSKISVNTRNILIDITATDKTKAEIVLNILTTMFSRYCDEPFTVEPVEIVSEHNGQSRLAPNFNDRIMDVSIKYINSCLGLDQSADEIAHCLKKMSLHAVQSKEDKDILHVDIPVTRPDILHACDIMEDAAVGYGFNNLPKGEKLSNANFIAKPLPINKVSDIFRVASSQATWVEVLPLTLCSHDENFKFLRQSDNGDLAVKLANPKTLEYQVVRTTLLPGILKTVKENRKHSLPIKVFETGDVVFKDDKLERKAYNERHWAAIYVGKNSGFEIIQGLLGKIMQTFRTEWIADYGAAASGRGYWIEEDDSVKTYFPGRGAKVMFRSKEGAEPKQIGHLGVLHPEVMMNFDVPFAASFVEVNAEVFL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MPTVSVNKQQLF ---CCCEECCHHHHH | 23.58 | 30377154 | |
| 8 | Ubiquitination | MPTVSVNKQQLFDLL CCCEECCHHHHHHHH | 36.95 | 24961812 | |
| 21 | Phosphorylation | LLGKNYTSQEFDELC HHCCCCCHHHHHHHH | 19.83 | 28889911 | |
| 93 | Acetylation | KLSKPTTKLIIDKST CCCCCCCEEEEECCC | 39.92 | 24489116 | |
| 98 | Acetylation | TTKLIIDKSTEQIRP CCEEEEECCCHHHHH | 49.20 | 24489116 | |
| 120 | Acetylation | RNIKLNEKSYASFIA HCCCCCCCCHHHHHH | 47.93 | 24489116 | |
| 124 | Phosphorylation | LNEKSYASFIALQDK CCCCCHHHHHHHHHH | 14.67 | 28889911 | |
| 131 | Acetylation | SFIALQDKLHANLCR HHHHHHHHHHHHHCC | 29.25 | 24489116 | |
| 152 | Phosphorylation | MGTHDLDSIEGPFHY EECCCHHHCCCCCEE | 29.81 | 30377154 | |
| 168 | Acetylation | ALPPKDIKFVPLNQT CCCCCCCEEEECCCC | 50.90 | 22865919 | |
| 182 | Acetylation | TQEFTGDKLIEFYKS CCCCCCCHHHHHHCC | 53.35 | 24489116 | |
| 188 | Acetylation | DKLIEFYKSPEQKNN CHHHHHHCCHHHHCC | 65.93 | 24489116 | |
| 189 | Phosphorylation | KLIEFYKSPEQKNNI HHHHHHCCHHHHCCC | 23.45 | 21440633 | |
| 193 | Acetylation | FYKSPEQKNNIGRYV HHCCHHHHCCCCCEE | 50.75 | 25381059 | |
| 193 | Ubiquitination | FYKSPEQKNNIGRYV HHCCHHHHCCCCCEE | 50.75 | 23749301 | |
| 206 | Phosphorylation | YVHIIEDSPVFPVIM EEEEECCCCCCEEEE | 15.35 | 22369663 | |
| 216 | Acetylation | FPVIMDSKDRVCSLP CEEEECCCCCEECCC | 45.34 | 24489116 | |
| 216 | Ubiquitination | FPVIMDSKDRVCSLP CEEEECCCCCEECCC | 45.34 | 23749301 | |
| 221 | Phosphorylation | DSKDRVCSLPPLINS CCCCCEECCCCCCCC | 40.84 | 21440633 | |
| 249 | Acetylation | IDITATDKTKAEIVL EEEECCCCCHHHHHH | 47.79 | 24489116 | |
| 306 | Phosphorylation | VSIKYINSCLGLDQS HHHHHHHHHCCCCCC | 10.93 | 21440633 | |
| 331 | Phosphorylation | MSLHAVQSKEDKDIL CCHHEECCCCCCCCE | 31.26 | 27017623 | |
| 373 | Ubiquitination | NNLPKGEKLSNANFI CCCCCCCCCCCCCEE | 66.92 | 23749301 | |
| 373 | Acetylation | NNLPKGEKLSNANFI CCCCCCCCCCCCCEE | 66.92 | 24489116 | |
| 375 | Phosphorylation | LPKGEKLSNANFIAK CCCCCCCCCCCEECC | 44.99 | 28889911 | |
| 382 | Acetylation | SNANFIAKPLPINKV CCCCEECCCCCCCHH | 42.12 | 24489116 | |
| 382 | Ubiquitination | SNANFIAKPLPINKV CCCCEECCCCCCCHH | 42.12 | 23749301 | |
| 388 | Ubiquitination | AKPLPINKVSDIFRV CCCCCCCHHHHHHHH | 43.78 | 23749301 | |
| 423 | Phosphorylation | NFKFLRQSDNGDLAV CCCEEEECCCCCEEE | 26.98 | 22369663 | |
| 431 | Ubiquitination | DNGDLAVKLANPKTL CCCCEEEEECCCCCE | 35.95 | 23749301 | |
| 431 | Acetylation | DNGDLAVKLANPKTL CCCCEEEEECCCCCE | 35.95 | 24489116 | |
| 436 | Ubiquitination | AVKLANPKTLEYQVV EEEECCCCCEEEEEE | 66.60 | 23749301 | |
| 436 | Acetylation | AVKLANPKTLEYQVV EEEECCCCCEEEEEE | 66.60 | 24489116 | |
| 437 | Phosphorylation | VKLANPKTLEYQVVR EEECCCCCEEEEEEH | 26.53 | 17563356 | |
| 453 | Acetylation | TLLPGILKTVKENRK HHCCCHHHHHHHHCC | 49.72 | 22865919 | |
| 453 | Ubiquitination | TLLPGILKTVKENRK HHCCCHHHHHHHHCC | 49.72 | 23749301 | |
| 476 | Acetylation | ETGDVVFKDDKLERK ECCCEEECCCHHHHH | 54.10 | 24489116 | |
| 476 | Succinylation | ETGDVVFKDDKLERK ECCCEEECCCHHHHH | 54.10 | 23954790 | |
| 479 | Acetylation | DVVFKDDKLERKAYN CEEECCCHHHHHHHH | 63.48 | 24489116 | |
| 541 | Acetylation | IEEDDSVKTYFPGRG ECCCCCCCEECCCCC | 41.27 | 24489116 | |
| 550 | Ubiquitination | YFPGRGAKVMFRSKE ECCCCCCEEEEECCC | 36.74 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYFB_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYFB_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYFB_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-124 AND SER-375, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-437, AND MASSSPECTROMETRY. | |
