| UniProt ID | ODPB_YEAST | |
|---|---|---|
| UniProt AC | P32473 | |
| Protein Name | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | |
| Gene Name | PDB1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 366 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).. | |
| Protein Sequence | MFSRLPTSLARNVARRAPTSFVRPSAAAAALRFSSTKTMTVREALNSAMAEELDRDDDVFLIGEEVAQYNGAYKVSKGLLDRFGERRVVDTPITEYGFTGLAVGAALKGLKPIVEFMSFNFSMQAIDHVVNSAAKTHYMSGGTQKCQMVFRGPNGAAVGVGAQHSQDFSPWYGSIPGLKVLVPYSAEDARGLLKAAIRDPNPVVFLENELLYGESFEISEEALSPEFTLPYKAKIEREGTDISIVTYTRNVQFSLEAAEILQKKYGVSAEVINLRSIRPLDTEAIIKTVKKTNHLITVESTFPSFGVGAEIVAQVMESEAFDYLDAPIQRVTGADVPTPYAKELEDFAFPDTPTIVKAVKEVLSIE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 47 | Phosphorylation | TVREALNSAMAEELD HHHHHHHHHHHHHCC | 21.92 | 24930733 | |
| 77 | Acetylation | NGAYKVSKGLLDRFG CCCEEECHHHHHHHC | 57.47 | 24489116 | |
| 77 | 2-Hydroxyisobutyrylation | NGAYKVSKGLLDRFG CCCEEECHHHHHHHC | 57.47 | - | |
| 145 | Acetylation | YMSGGTQKCQMVFRG CCCCCCEEEEEEEEC | 26.69 | 24489116 | |
| 240 | Phosphorylation | AKIEREGTDISIVTY EEEEECCCEEEEEEE | 25.96 | 28889911 | |
| 264 | Acetylation | AAEILQKKYGVSAEV HHHHHHHHHCCCEEE | 33.99 | 24489116 | |
| 268 | Phosphorylation | LQKKYGVSAEVINLR HHHHHCCCEEEEECC | 17.85 | 24961812 | |
| 276 | Phosphorylation | AEVINLRSIRPLDTE EEEEECCCCCCCCHH | 26.56 | 21440633 | |
| 282 | Phosphorylation | RSIRPLDTEAIIKTV CCCCCCCHHHHHHHH | 34.69 | 22369663 | |
| 287 | Acetylation | LDTEAIIKTVKKTNH CCHHHHHHHHHHCCC | 40.95 | 24489116 | |
| 342 | Acetylation | DVPTPYAKELEDFAF CCCCCCHHHHHHHCC | 57.92 | 24489116 | |
| 352 | Phosphorylation | EDFAFPDTPTIVKAV HHHCCCCCHHHHHHH | 23.67 | 17330950 | |
| 354 | Phosphorylation | FAFPDTPTIVKAVKE HCCCCCHHHHHHHHH | 40.26 | 24961812 | |
| 357 | Acetylation | PDTPTIVKAVKEVLS CCCHHHHHHHHHHHC | 43.54 | 24489116 | |
| 360 | Acetylation | PTIVKAVKEVLSIE- HHHHHHHHHHHCCC- | 47.14 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ODPB_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ODPB_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ODPB_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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