YL345_YEAST - dbPTM
YL345_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID YL345_YEAST
UniProt AC Q06137
Protein Name Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W
Gene Name YLR345W
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 509
Subcellular Localization Cytoplasm .
Protein Description Synthesis and degradation of fructose 2,6-bisphosphate..
Protein Sequence MPNVLSDDEELLNGLGSEIMKPSRQGNHMARTVKRWVNKERATTADLKNVNIDGVHGPVNTESYISPGQLYSTDSGNLFHAGRILVVLVGLPATSKTLLSVAITRYTRWLGVRTKSFHFSEYKESAKNIPSDYFCVVPTSKEGVAFVEKLRMQMLNDILAFFNDLSGQLAIYDALNIRKIDRKNLETTFSEIGVKVLFIESIVSDQEIMNRNIALALESNDYKGLSTDEAIDEYMRRLSVNEPYYEMMTHDEELSYIKYINLGKQIIVKDNIHGYLVNKIVFFLMNLRQKKGCVYFARCGTSDKDNYIHDEELNEEGIHYSQVLKDFVLQRIKQKRQAKKNSDSLVEVIDGSHDEDLKTSLIVWTGPRKRTHDTALFFSKEGIKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHTSKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFCNTVELLNIPLTS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MPNVLSDDEELLN
--CCCCCCCHHHHHH		38.4422369663
17PhosphorylationELLNGLGSEIMKPSR
HHHHHCCCCCCCCCC		29.0622369663
21AcetylationGLGSEIMKPSRQGNH
HCCCCCCCCCCCCCH		45.5725381059
23PhosphorylationGSEIMKPSRQGNHMA
CCCCCCCCCCCCHHH		31.5522369663
72PhosphorylationISPGQLYSTDSGNLF
CCCCCEEECCCCCCE		34.0430377154
75PhosphorylationGQLYSTDSGNLFHAG
CCEEECCCCCCEECC		29.6628889911
104PhosphorylationTLLSVAITRYTRWLG
HHHHHHHHHHHHHHC		14.1117563356
149AcetylationEGVAFVEKLRMQMLN
HHHHHHHHHHHHHHH		35.7724489116
190PhosphorylationKNLETTFSEIGVKVL
CCCCCCHHHHCCEEE		26.6428889911
219PhosphorylationNIALALESNDYKGLS
HHHHHHHCCCCCCCC		35.5328889911
344PhosphorylationQAKKNSDSLVEVIDG
HHHHCCCCCEEECCC		33.8528889911
432PhosphorylationFRFPRAESYHDLAVR
CCCCCCCCHHHHHHH		27.1227214570
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of YL345_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of YL345_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of YL345_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTR3_YEASTMTR3physical
10688190
BMH2_YEASTBMH2physical
16554755
YM91_YEASTYMR310Cphysical
16554755
STE13_YEASTSTE13physical
16554755
F26_YEASTFBP26physical
16429126
HSP73_YEASTSSA3physical
16429126
SFH1_YEASTSFH1physical
11283351
TPS3_YEASTTPS3physical
18467557
YL345_YEASTYLR345Wphysical
18719252
SFH1_YEASTSFH1physical
18719252
MTR3_YEASTMTR3physical
18719252
CTK1_YEASTCTK1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
VPS4_YEASTVPS4genetic
27708008
VPS8_YEASTVPS8genetic
27708008
SEC66_YEASTSEC66genetic
27708008
BUD31_YEASTBUD31genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
MDHP_YEASTMDH3genetic
27708008
RL13A_YEASTRPL13Agenetic
27708008
BAP3_YEASTBAP3genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
EF2_YEASTEFT2genetic
27708008
YBP2_YEASTYBP2genetic
27708008
MED5_YEASTNUT1genetic
27708008
GTR2_YEASTGTR2genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YIQ3_YEASTYIL163Cgenetic
27708008
ALLA_YEASTDAL3genetic
27708008
PEX2_YEASTPEX2genetic
27708008
YJ09_YEASTYJR039Wgenetic
27708008
DHOM_YEASTHOM6genetic
27708008
PRR1_YEASTPRR1genetic
27708008
ELF1_YEASTELF1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
YKZ5_YEASTYKR015Cgenetic
27708008
FPS1_YEASTFPS1genetic
27708008
YL012_YEASTYLR012Cgenetic
27708008
DPH6_YEASTDPH6genetic
27708008
PEX13_YEASTPEX13genetic
27708008
LGUL_YEASTGLO1genetic
27708008
NAB6_YEASTNAB6genetic
27708008
TPM1_YEASTTPM1genetic
27708008
OCA1_YEASTOCA1genetic
27708008
PABS_YEASTABZ1genetic
27708008
INO4_YEASTINO4genetic
27708008
CYC2_YEASTCYC2genetic
27708008
SFL1_YEASTSFL1genetic
27708008
ATG40_YEASTYOR152Cgenetic
27708008
CHL1_YEASTCHL1genetic
27708008
PPQ1_YEASTPPQ1genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of YL345_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6; SER-75 AND SER-432,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104, AND MASSSPECTROMETRY.

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