LGUL_YEAST - dbPTM
LGUL_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LGUL_YEAST
UniProt AC P50107
Protein Name Lactoylglutathione lyase
Gene Name GLO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 326
Subcellular Localization
Protein Description Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione..
Protein Sequence MSTDSTRYPIQIEKASNDPTLLLNHTCLRVKDPARTVKFYTEHFGMKLLSRKDFEEAKFSLYFLSFPKDDIPKNKNGEPDVFSAHGVLELTHNWGTEKNPDYKINNGNEEPHRGFGHICFSVSDINKTCEELESQGVKFKKRLSEGRQKDIAFALGPDGYWIELITYSREGQEYPKGSVGNKFNHTMIRIKNPTRSLEFYQNVLGMKLLRTSEHESAKFTLYFLGYGVPKTDSVFSCESVLELTHNWGTENDPNFHYHNGNSEPQGYGHICISCDDAGALCKEIEVKYGDKIQWSPKFNQGRMKNIAFLKDPDGYSIEVVPHGLIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14UbiquitinationRYPIQIEKASNDPTL
CCCEEEEECCCCCEE		59.7617644757
38AcetylationKDPARTVKFYTEHFG
CCHHHEEEEEHHHCC		31.8524489116
96PhosphorylationELTHNWGTEKNPDYK
EECCCCCCCCCCCCC		35.0928889911
138AcetylationELESQGVKFKKRLSE
HHHHCCCCCHHHHCC		59.2924489116
182AcetylationPKGSVGNKFNHTMIR
CCCCCCCCCCCEEEE		41.4324489116
291AcetylationIEVKYGDKIQWSPKF
EEEEECCEECCCCCC		32.2224489116
295PhosphorylationYGDKIQWSPKFNQGR
ECCEECCCCCCCCCC		11.2219795423
297AcetylationDKIQWSPKFNQGRMK
CEECCCCCCCCCCCC		51.9724489116
304AcetylationKFNQGRMKNIAFLKD
CCCCCCCCEEEEEEC		43.7924489116
310UbiquitinationMKNIAFLKDPDGYSI
CCEEEEEECCCCCEE		61.8424961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LGUL_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LGUL_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LGUL_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GRE3_YEASTGRE3genetic
11525399
SSB1_YEASTSSB1physical
19536198
GGPPS_YEASTBTS1genetic
21623372
THDH_YEASTILV1genetic
21623372
UBC3_YEASTCDC34genetic
27708008
SEC22_YEASTSEC22genetic
27708008
MAK5_YEASTMAK5genetic
27708008
GPI19_YEASTGPI19genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
MED6_YEASTMED6genetic
27708008
ESS1_YEASTESS1genetic
27708008
FNTA_YEASTRAM2genetic
27708008
PRP19_YEASTPRP19genetic
27708008
RNA1_YEASTRNA1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
TYSY_YEASTCDC21genetic
27708008
APC5_YEASTAPC5genetic
27708008
GPI2_YEASTGPI2genetic
27708008
DIB1_YEASTDIB1genetic
27708008
HSP31_YEASTHSP31genetic
27984092
HSP32_YEASTHSP32genetic
27984092
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LGUL_YEAST

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Related Literatures of Post-Translational Modification

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