DBP6_YEAST - dbPTM
DBP6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DBP6_YEAST
UniProt AC P53734
Protein Name ATP-dependent RNA helicase DBP6
Gene Name DBP6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 629
Subcellular Localization Nucleus, nucleolus .
Protein Description ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs..
Protein Sequence MFASRFDPSQLTAPAASAPEGIVGTTPPAIVPLKRQATESDNEEYGSHQDSDESSNSSSEEDEDRMQVDYGASEEDSSEVEEEESKPSTHSTVLSRFKQTVSLQERLGASDIAESKEDEGIEDEAASTHQLKQIPQPEFVKNPMNLNTNSLQFKSTGWLNTEKIYYDNSLIKPFSDYANELEAKLLQNICKNFSTNTFPIQSIILDSILPVLNFTLNVSKRNFTRRIGDILVNAATGSGKTLAYSIPIVQTLFKRQINRLRCIIIVPTKLLINQVYTTLTKLTQGTSLIVSIAKLENSLKDEHKKLSNLEPDILITTPGRLVDHLNMKSINLKNLKFLIIDEADRLLNQSFQGWCPKLMSHLKTDKLDTLPGNVIKMIFSATLTTNTEKLNGLNLYKPKLFLKQTDKLYQLPNKLNEFNINIPTAKSVYKPLILLYSICQFMAHSPIAAKILIFVKSNESSIRLSKLLQLICESRSQSSVLKNLQNLAVSINSVNSNNSKAENKKIVANFSHHSESAGITILITTDIMSRGIDINDITQVINYDPPMSSQQYVHRVGRTARANELGSAYNLLVGRGERTFFDDLNKDLDRDGKSVQPLELDFTLLESDSELYTSSLESLKNYHNNTAQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationFASRFDPSQLTAPAA
CCCCCCHHHCCCCCC		39.4029688323
12PhosphorylationRFDPSQLTAPAASAP
CCCHHHCCCCCCCCC		23.9829688323
17PhosphorylationQLTAPAASAPEGIVG
HCCCCCCCCCCCCCC		46.6029688323
25PhosphorylationAPEGIVGTTPPAIVP
CCCCCCCCCCCCEEE		25.8228889911
26PhosphorylationPEGIVGTTPPAIVPL
CCCCCCCCCCCEEEC		22.7317563356
70PhosphorylationEDRMQVDYGASEEDS
HHHHHHCCCCCCCCC		18.7419795423
73PhosphorylationMQVDYGASEEDSSEV
HHHCCCCCCCCCCHH		36.8417330950
77PhosphorylationYGASEEDSSEVEEEE
CCCCCCCCCHHCHHH		31.5117330950
78PhosphorylationGASEEDSSEVEEEES
CCCCCCCCHHCHHHC		58.9617330950
85PhosphorylationSEVEEEESKPSTHST
CHHCHHHCCCCCHHH		53.8219795423
98AcetylationSTVLSRFKQTVSLQE
HHHHHHHHHHHCHHH		43.9025381059
102PhosphorylationSRFKQTVSLQERLGA
HHHHHHHCHHHHHCC		27.9428889911
110PhosphorylationLQERLGASDIAESKE
HHHHHCCHHHHHCCC		27.9627017623
115PhosphorylationGASDIAESKEDEGIE
CCHHHHHCCCCCCCC		32.1227017623
127PhosphorylationGIEDEAASTHQLKQI
CCCCHHHHHHHHHCC		33.2123749301
128PhosphorylationIEDEAASTHQLKQIP
CCCHHHHHHHHHCCC		14.6525752575
148PhosphorylationKNPMNLNTNSLQFKS
CCCCCCCCCCCEEEE		29.3830377154
163AcetylationTGWLNTEKIYYDNSL
CCCCCCEEEEECCCC		33.6922865919
236PhosphorylationDILVNAATGSGKTLA
HEEEECCCCCCCHHH		29.4828889911
238PhosphorylationLVNAATGSGKTLAYS
EEECCCCCCCHHHHH		32.5328889911
283PhosphorylationYTTLTKLTQGTSLIV
HHHHHHHHCCCCHHH		26.8919823750
286PhosphorylationLTKLTQGTSLIVSIA
HHHHHCCCCHHHHHH		15.5619823750
287PhosphorylationTKLTQGTSLIVSIAK
HHHHCCCCHHHHHHH		23.9519823750
291PhosphorylationQGTSLIVSIAKLENS
CCCCHHHHHHHHHHH		15.1619823750
298PhosphorylationSIAKLENSLKDEHKK
HHHHHHHHCCHHHHH		27.6728889911
397AcetylationLNGLNLYKPKLFLKQ
HCCCCCCCCEEHHHC		38.5524489116
399AcetylationGLNLYKPKLFLKQTD
CCCCCCCEEHHHCHH		47.9524489116
543PhosphorylationDITQVINYDPPMSSQ
HHHHCCCCCCCCCHH		20.7819779198
548PhosphorylationINYDPPMSSQQYVHR
CCCCCCCCHHHHHHH		30.6719779198
552PhosphorylationPPMSSQQYVHRVGRT
CCCCHHHHHHHHHHH		7.2119779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DBP6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DBP6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DBP6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RSA3_YEASTRSA3physical
15126390
DBP9_YEASTDBP9genetic
11565753
RSA1_YEASTRSA1genetic
10567587
FBRL_YEASTNOP1physical
16554755
PWP1_YEASTPWP1physical
16554755
MOG1_YEASTMOG1genetic
19061648
SSB1_YEASTSSB1physical
19536198
NMD2_YEASTNMD2physical
25277656
URB2_YEASTURB2physical
25877921
RRP14_YEASTRRP14physical
25877921
URB1_YEASTURB1physical
25877921
RLP7_YEASTRLP7physical
25877921
NOG2_YEASTNOG2physical
25877921
RRS1_YEASTRRS1physical
25877921
LOC1_YEASTLOC1physical
25877921
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CHK1_YEASTCHK1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
IPT1_YEASTIPT1genetic
27708008
RCY1_YEASTRCY1genetic
27708008
SIS2_YEASTSIS2genetic
27708008
ELO3_YEASTELO3genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
OPT2_YEASTOPT2genetic
27708008
MAK16_YEASTMAK16genetic
27708008
SEC17_YEASTSEC17genetic
27708008
MAK5_YEASTMAK5genetic
27708008
CDK1_YEASTCDC28genetic
27708008
SCC1_YEASTMCD1genetic
27708008
FBRL_YEASTNOP1genetic
27708008
RRP42_YEASTRRP42genetic
27708008
CDC53_YEASTCDC53genetic
27708008
NHP2_YEASTNHP2genetic
27708008
DAD1_YEASTDAD1genetic
27708008
UBC3_YEASTCDC34genetic
27708008
RRP1_YEASTRRP1genetic
27708008
ERF3_YEASTSUP35genetic
27708008
CDC1_YEASTCDC1genetic
27708008
MSS4_YEASTMSS4genetic
27708008
SMT3_YEASTSMT3genetic
27708008
GDI1_YEASTGDI1genetic
27708008
RRP41_YEASTSKI6genetic
27708008
CP51_YEASTERG11genetic
27708008
BCD1_YEASTBCD1genetic
27708008
RRP4_YEASTRRP4genetic
27708008
RPF1_YEASTRPF1genetic
27708008
CDC12_YEASTCDC12genetic
27708008
UTP9_YEASTUTP9genetic
27708008
SHQ1_YEASTSHQ1genetic
27708008
MTR4_YEASTMTR4genetic
27708008
MAK11_YEASTMAK11genetic
27708008
ABF1_YEASTABF1genetic
27708008
NOP56_YEASTNOP56genetic
27708008
DBP9_YEASTDBP9genetic
27708008
IMB1_YEASTKAP95genetic
27708008
POB3_YEASTPOB3genetic
27708008
MED11_YEASTMED11genetic
27708008
RNT1_YEASTRNT1genetic
27708008
RRP44_YEASTDIS3genetic
27708008
BRX1_YEASTBRX1genetic
27708008
MED7_YEASTMED7genetic
27708008
GRPE_YEASTMGE1genetic
27708008
DYR_YEASTDFR1genetic
27708008
SYA_YEASTALA1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
ATC3_YEASTDRS2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
SEC66_YEASTSEC66genetic
27708008
AIM4_YEASTAIM4genetic
27708008
PYC2_YEASTPYC2genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
THRC_YEASTTHR4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
SWI4_YEASTSWI4genetic
27708008
PALF_YEASTRIM8genetic
27708008
MED5_YEASTNUT1genetic
27708008
RTG2_YEASTRTG2genetic
27708008
G3P3_YEASTTDH3genetic
27708008
YG5X_YEASTYGR283Cgenetic
27708008
PIH1_YEASTPIH1genetic
27708008
LRP1_YEASTLRP1genetic
27708008
STB5_YEASTSTB5genetic
27708008
AIR1_YEASTAIR1genetic
27708008
HPM1_YEASTHPM1genetic
27708008
DBP7_YEASTDBP7genetic
27708008
ERG3_YEASTERG3genetic
27708008
RSA3_YEASTRSA3genetic
27708008
PPZ1_YEASTPPZ1genetic
27708008
HSC82_YEASTHSC82genetic
27708008
YM60_YEASTYMR210Wgenetic
27708008
SCS7_YEASTSCS7genetic
27708008
YM91_YEASTYMR310Cgenetic
27708008
NOP12_YEASTNOP12genetic
27708008
RRP6_YEASTRRP6genetic
27708008
CHL1_YEASTCHL1genetic
27708008
NEW1_YEASTNEW1genetic
27708008
DSS4_YEASTDSS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DBP6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-73; SER-77 AND SER-78,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-26, AND MASSSPECTROMETRY.

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