| UniProt ID | URB2_YEAST | |
|---|---|---|
| UniProt AC | P47108 | |
| Protein Name | Nucleolar pre-ribosomal-associated protein 2 | |
| Gene Name | URB2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1174 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly.. | |
| Protein Sequence | MGDLTEELSIPDNAQDLSKLLRSTSTKPHQIAEIVSKFDKLETYFPKKEIFVLDLLIDRLNNGNLDDFKTSEHTWIIFTRLLDAINDPISIKKLLKKLKTVPVMIRTFFLWPKDKLLTRSVSFIKAFFAINDYLIVNFSVEESFQLLEHAINGLSSCPTTDFALSYLQDACNLTHVDNITTTDNKIATCYCKHMLLPSLRYFAQTKNSASSNQSFIRLSHFMGKFLLQPRIDYMKLNKKFVQENASEITDDMAYYYFATFVTFLSKDNFAQLEVIFTILGAKKPSLECRFLNLLSESKKTVSQEFLEALLLEMLASTDESGVLSLIPIILKLDIEVAIKHIFRLLELIQLENLNDPLFSSHIWDLIIQSHANARELSDFFAKINEYCSRKGPDSYFLINHPAYVKSITKQLFTLSSLQWKNLLQALLDQVNHDSTNRVPLYLIRICLEGLSEGASRATLDEVKPILSQVFTLESFNNSLQWDLKYHIMEVYDDIVPAEELEKIDYVLSSNIFDTTSADVEELFFYCFKLREYISFDLSDAKKKFMRHFEILDEERKSNLSYSVVSKFATLVNNNFTREQISSLIDSLLLNSTNLSSLLKNDDIFEETNITYALINKLASSYHQTFALEALIQIPIQCINKNVRVALINNLTCESFCLDSATRECLLHLLSSPTFKSNIETNFYELCEKTIMSPEMAISETGDEKKEIEDKISIFEKVWTNHLSQAKEPVSEKFLESGYDIVKQSMSLSNGDSKLIIAGFTIAKFLKPDNKHRDIQGMAISYAVKILENYSENFESETIPLFRISMSTLYKIITTGQGDISKHKSRILDIFSKIMLRYHSKKVYHAPEEQEMFLVHSLLTENKLEYIFAEYLNIEHTDKCDSALGFCLEESLKQGPDAFNRLLWNSAKSFSTISQPCAEKFVRVFIIMSKRIARDNNLGHHLFVIALLEAYTYCDIEKFGYKSYLLLFNAIKEFLVSKPWLFSQYCIEMLLPFCLKTLAFIVNHESTDEINEGFINIIEVIDHMLLVHRFKFSNRHHLFNSVLCQILEIIAIHDGTLCANSADAVARLITNYCEPYNVSNAQNGQKNNLSSKISLIKQSIRKNVLVVLTKYIQLSITTQFSLNIKKSLQPGIHAIFDILSQNELNQLNAFLDTPGKQYFKALYLQYKKVGKWRED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 26 | Phosphorylation | KLLRSTSTKPHQIAE HHHHCCCCCHHHHHH | 49.00 | 27017623 | |
| 36 | Phosphorylation | HQIAEIVSKFDKLET HHHHHHHHHHHHHHH | 33.01 | 27017623 | |
| 40 | Acetylation | EIVSKFDKLETYFPK HHHHHHHHHHHHCCH | 51.89 | 24489116 | |
| 71 | Phosphorylation | NLDDFKTSEHTWIIF CCCCCCCCCCHHHHH | 28.15 | 19779198 | |
| 206 | Ubiquitination | LRYFAQTKNSASSNQ HHHHHHCCCCCCCCC | 36.50 | 23749301 | |
| 208 | Phosphorylation | YFAQTKNSASSNQSF HHHHCCCCCCCCCCH | 30.96 | 19823750 | |
| 210 | Phosphorylation | AQTKNSASSNQSFIR HHCCCCCCCCCCHHH | 29.64 | 19823750 | |
| 211 | Phosphorylation | QTKNSASSNQSFIRL HCCCCCCCCCCHHHH | 38.31 | 19823750 | |
| 214 | Phosphorylation | NSASSNQSFIRLSHF CCCCCCCCHHHHHHH | 27.22 | 19823750 | |
| 219 | Phosphorylation | NQSFIRLSHFMGKFL CCCHHHHHHHHHHHH | 12.58 | 19823750 | |
| 562 | Phosphorylation | RKSNLSYSVVSKFAT HHHCCCHHHHHHHHH | 16.80 | 25371407 | |
| 569 | Phosphorylation | SVVSKFATLVNNNFT HHHHHHHHHHCCCCC | 34.08 | 28889911 | |
| 752 | Phosphorylation | MSLSNGDSKLIIAGF HCCCCCCCEEEEEEE | 30.66 | 28889911 | |
| 907 | Ubiquitination | RLLWNSAKSFSTISQ HHHHHHCCCCCCCCH | 52.43 | 23749301 | |
| 1120 | Phosphorylation | LSITTQFSLNIKKSL EEEEEEEECCCHHHC | 15.64 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of URB2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of URB2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of URB2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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