TBCA_YEAST - dbPTM
TBCA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBCA_YEAST
UniProt AC P48606
Protein Name Tubulin-specific chaperone A
Gene Name RBL2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 106
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Tubulin-folding protein; involved in the early step of the tubulin folding pathway..
Protein Sequence MAPTQLDIKVKALKRLTKEEGYYQQELKDQEAHVAKLKEDKSVDPYDLKKQEEVLDDTKRLLPTLYEKIREFKEDLEQFLKTYQGTEDVSDARSAITSAQELLDSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18UbiquitinationKALKRLTKEEGYYQQ
HHHHHHHHHCCCCHH		59.3623749301
18AcetylationKALKRLTKEEGYYQQ
HHHHHHHHHCCCCHH		59.3624489116
41AcetylationVAKLKEDKSVDPYDL
HHHHHHCCCCCHHCH		54.1724489116
49SuccinylationSVDPYDLKKQEEVLD
CCCHHCHHHHHHHHH		49.8923954790
68AcetylationLLPTLYEKIREFKED
HHHHHHHHHHHHHHH		33.2424489116
82PhosphorylationDLEQFLKTYQGTEDV
HHHHHHHHHCCCCCH		24.1922369663
83PhosphorylationLEQFLKTYQGTEDVS
HHHHHHHHCCCCCHH		11.8922369663
86PhosphorylationFLKTYQGTEDVSDAR
HHHHHCCCCCHHHHH		17.3122369663
90PhosphorylationYQGTEDVSDARSAIT
HCCCCCHHHHHHHHH		37.5622369663
94PhosphorylationEDVSDARSAITSAQE
CCHHHHHHHHHHHHH		26.2422369663
97PhosphorylationSDARSAITSAQELLD
HHHHHHHHHHHHHHH		20.0922890988
98PhosphorylationDARSAITSAQELLDS
HHHHHHHHHHHHHHC		23.1122890988
105PhosphorylationSAQELLDSK------
HHHHHHHCC------		39.9922369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBCA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBCA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBCA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PFD2_YEASTGIM4genetic
14764870
PAC2_YEASTPAC2genetic
14764870
PFD3_YEASTPAC10genetic
14764870
PFD6_YEASTYKE2genetic
14764870
CIN4_YEASTCIN4genetic
14764870
PFD4_YEASTGIM3genetic
14764870
BUB3_YEASTBUB3genetic
14764870
TBCC_YEASTCIN2genetic
14764870
TBB_YEASTTUB2physical
7634332
TBB_YEASTTUB2physical
9488492
TBCA_YEASTRBL2physical
10542082
TBB_YEASTTUB2physical
15321725
TBB_YEASTTUB2physical
10978276
TBA1_YEASTTUB1genetic
9611197
RPIA_YEASTRKI1genetic
9914379
TBA1_YEASTTUB1genetic
9725898
PFD5_YEASTGIM5genetic
17314980
PFD3_YEASTPAC10genetic
17314980
PFD2_YEASTGIM4genetic
17314980
PFD6_YEASTYKE2genetic
17314980
HUR1_YEASTHUR1genetic
17314980
BUB3_YEASTBUB3genetic
17314980
BUB1_YEASTBUB1genetic
17314980
2A5D_YEASTRTS1genetic
17314980
COA4_YEASTCOA4genetic
17314980
SWI5_YEASTSWI5genetic
17314980
UME6_YEASTUME6genetic
17314980
CIN8_YEASTCIN8genetic
17314980
SIN3_YEASTSIN3genetic
17314980
SAC3_YEASTSAC3genetic
17314980
IES2_YEASTIES2genetic
17314980
MET18_YEASTMET18genetic
17314980
RIM1_YEASTRIM1genetic
17314980
SGF73_YEASTSGF73genetic
17314980
XRN1_YEASTXRN1genetic
17314980
MED20_YEASTSRB2genetic
17314980
MED3_YEASTPGD1genetic
17314980
PAC2_YEASTPAC2genetic
17314980
SPT3_YEASTSPT3genetic
17314980
CDC73_YEASTCDC73genetic
17314980
CSK2B_YEASTCKB1genetic
17314980
RAD61_YEASTRAD61genetic
17314980
TBCA_YEASTRBL2physical
10542094
JSN1_YEASTJSN1physical
18719252
YB47_YEASTYBR197Cgenetic
20093466
BEM1_YEASTBEM1genetic
20093466
RV161_YEASTRVS161genetic
20093466
PEX19_YEASTPEX19genetic
20093466
RV167_YEASTRVS167genetic
20093466
MED5_YEASTNUT1genetic
20093466
ICE2_YEASTICE2genetic
20093466
LSM1_YEASTLSM1genetic
20093466
UBI4P_YEASTUBI4genetic
20093466
PEX13_YEASTPEX13genetic
20093466
PFD6_YEASTYKE2genetic
20093466
TBA3_YEASTTUB3genetic
20093466
SSO2_YEASTSSO2genetic
20093466
GAS1_YEASTGAS1genetic
20093466
PFD4_YEASTGIM3genetic
20093466
BUB3_YEASTBUB3genetic
20093466
VPS21_YEASTVPS21genetic
20093466
TBCC_YEASTCIN2genetic
20093466
RU2A_YEASTLEA1genetic
20093466
PFD5_YEASTGIM5genetic
14764870
TBA3_YEASTTUB3genetic
14764870
CIN1_YEASTCIN1genetic
14764870
SUM1_YEASTSUM1genetic
22285862
TBB_YEASTTUB2physical
9725898
ELO3_YEASTELO3genetic
23891562
SSO2_YEASTSSO2genetic
23891562
SEC4_YEASTSEC4genetic
23891562
TPM1_YEASTTPM1genetic
23891562
PFD2_YEASTGIM4genetic
23891562
PFD3_YEASTPAC10genetic
23891562
PFD4_YEASTGIM3genetic
23891562
STU1_YEASTSTU1genetic
27708008
TRS20_YEASTTRS20genetic
27708008
PRP9_YEASTPRP9genetic
27708008
FAD1_YEASTFAD1genetic
27708008
TCPD_YEASTCCT4genetic
27708008
TCPZ_YEASTCCT6genetic
27708008
SYF1_YEASTSYF1genetic
27708008
SEC20_YEASTSEC20genetic
27708008
COG3_YEASTCOG3genetic
27708008
SAD1_YEASTSAD1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
PRP18_YEASTPRP18genetic
27708008
EXO70_YEASTEXO70genetic
27708008
BOS1_YEASTBOS1genetic
27708008
RU1C_YEASTYHC1genetic
27708008
CEF1_YEASTCEF1genetic
27708008
PRP2_YEASTPRP2genetic
27708008
ATC3_YEASTDRS2genetic
27708008
RV161_YEASTRVS161genetic
27708008
PEX19_YEASTPEX19genetic
27708008
OST4_YEASTOST4genetic
27708008
MED5_YEASTNUT1genetic
27708008
PFD3_YEASTPAC10genetic
27708008
VMA21_YEASTVMA21genetic
27708008
ICE2_YEASTICE2genetic
27708008
VPS53_YEASTVPS53genetic
27708008
YJ24_YEASTKCH1genetic
27708008
ELM1_YEASTELM1genetic
27708008
UBI4P_YEASTUBI4genetic
27708008
SWI6_YEASTSWI6genetic
27708008
PFD6_YEASTYKE2genetic
27708008
TBA3_YEASTTUB3genetic
27708008
SSO2_YEASTSSO2genetic
27708008
GAS1_YEASTGAS1genetic
27708008
TGL3_YEASTTGL3genetic
27708008
PFD4_YEASTGIM3genetic
27708008
BUB3_YEASTBUB3genetic
27708008
TSNAX_HUMANTSNAXphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBCA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, AND MASSSPECTROMETRY.

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