| UniProt ID | TBA3_YEAST | |
|---|---|---|
| UniProt AC | P09734 | |
| Protein Name | Tubulin alpha-3 chain | |
| Gene Name | TUB3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 445 | |
| Subcellular Localization | Cytoplasm, cytoskeleton. | |
| Protein Description | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.. | |
| Protein Sequence | MREVISINVGQAGCQIGNACWELYSLEHGIKEDGHLEDGLSKPKGGEEGFSTFFHETGYGKFVPRAIYVDLEPNVIDEVRTGRFKELFHPEQLINGKEDAANNYARGHYTVGREIVDEVEERIRKMADQCDGLQGFLFTHSLGGGTGSGLGSLLLENLSYEYGKKSKLEFAVYPAPQLSTSVVEPYNTVLTTHTTLEHADCTFMVDNEAIYDICKRNLGISRPSFSNLNGLIAQVISSVTASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVSYAPILSKKRATHESNSVSEITNACFEPGNQMVKCDPTKGKYMANCLLYRGDVVTRDVQRAVEQVKNKKTVQMVDWCPTGFKIGICYEPPSVIPSSELANVDRAVCMLSNTTAIADAWKRIDQKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGADSYAEEF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Ubiquitination | EDGLSKPKGGEEGFS CCCCCCCCCCCCCCH | 81.12 | 17644757 | |
| 51 | Phosphorylation | KGGEEGFSTFFHETG CCCCCCCHHCCCCCC | 34.85 | 21440633 | |
| 61 | Ubiquitination | FHETGYGKFVPRAIY CCCCCCCCEECEEEE | 34.40 | 17644757 | |
| 97 | Acetylation | PEQLINGKEDAANNY HHHHHCCCHHHHHHC | 48.18 | 24489116 | |
| 312 | Acetylation | KCDPTKGKYMANCLL EECCCCCCEECCHHE | 33.15 | 24489116 | |
| 313 | Phosphorylation | CDPTKGKYMANCLLY ECCCCCCEECCHHEE | 15.32 | 22369663 | |
| 320 | Phosphorylation | YMANCLLYRGDVVTR EECCHHEECCCEEHH | 10.29 | 22369663 | |
| 353 | Ubiquitination | DWCPTGFKIGICYEP EECCCCEEEEEEECC | 41.17 | 17644757 | |
| 395 | Acetylation | AWKRIDQKFDLMYAK HHHHHHHHHHHHHHE | 36.78 | 24489116 | |
| 400 | Phosphorylation | DQKFDLMYAKRAFVH HHHHHHHHHEEHHHE | 19.10 | 22369663 | |
| 440 | Phosphorylation | YIEVGADSYAEEF-- HEEECCCHHHHCC-- | 26.21 | 19795423 | |
| 441 | Phosphorylation | IEVGADSYAEEF--- EEECCCHHHHCC--- | 20.69 | 19779198 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TBA3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TBA3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TBA3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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